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Some species exhibit very high levels of DNA sequence variability; there is also evidence for the existence of heritable epigenetic variants that experience state changes at a much higher rate than sequence variants. In both cases, the…

Populations and Evolution · Quantitative Biology 2016-01-13 Brian Charlesworth , Kavita Jain

Fixation probabilities are essential for characterizing stochastic evolutionary dynamics, but analytical results remain limited mainly to systems with two competing types. We develop a perturbative framework to compute fixation…

Populations and Evolution · Quantitative Biology 2026-04-15 Ian Braga , Lucas Wardil , Ricardo Martinez-Garcia

Evolutionary graph theory models the effects of natural selection and random drift on structured populations of competing mutant and non-mutant individuals. Recent studies have found that fixation times in such systems often have…

Populations and Evolution · Quantitative Biology 2019-07-31 David Hathcock , Steven H. Strogatz

Recent studies on epistatic networks of model organisms have unveiled a certain type of modular property called monochromaticity in which the networks are clusterable into functional modules that interact with each other through the same…

Molecular Networks · Quantitative Biology 2013-05-30 Arda Halu , Ginestra Bianconi

The relationship between the Moran model and stochastic Lotka-Volterra competition (SLVC) model is explored via timescale separation arguments. For neutral systems the two are found to be equivalent at long times. For systems with selective…

Populations and Evolution · Quantitative Biology 2015-04-16 George W. A. Constable , Alan J. McKane

We seek models for the genotype evolution of agricultural animals, animals involved in primary production processes. Classical models for genotype evolution have tended to be very simple in order that analytic methods may be employed in…

Quantitative Methods · Quantitative Biology 2017-12-15 Vladimir Obolonkin , Anatoly Zherelo , George Krylov , Murray Jorgensen , Richard Spelman

For a population with any given number of types, we construct a new multivariate Moran process with frequency-dependent selection and establish, analytically, a correspondence to equilibrium Lotka-Volterra phenomenology. This…

Populations and Evolution · Quantitative Biology 2015-05-30 Andrew E. Noble , Alan Hastings , William F. Fagan

We propose a model for evolutionary game dynamics with three strategies $A$, $B$ and $C$ in the framework of Moran process in finite populations. The model can be described as a stochastic process which can be numerically computed from a…

Physics and Society · Physics 2007-05-23 Jing Wang , Feng Fu , Long Wang , Guangming Xie

Heterozygote disadvantage is potentially a potent driver of population genetic divergence. Also referred to as underdominance, this phenomena describes a situation where a genetic heterozygote has a lower overall fitness than either…

Populations and Evolution · Quantitative Biology 2015-09-29 Áki J. Láruson , Floyd A. Reed

The goal of this article is to study the limit of the empirical distribution induced by a mutation-selection multi-allelic Moran model, whose dynamic is given by a continuous-time irreducible Markov chain. The rate matrix driving the…

Probability · Mathematics 2022-09-28 Bertrand Cloez , Josué Corujo

In this short communication, we shall explore a nonlinear discrete dynamical system that naturally occurs in population systems to describe a transmission of a trait from parents to their offspring. We consider a Mendelian inheritance for a…

Dynamical Systems · Mathematics 2013-04-23 Nasir Ganikhodjaev , Mansoor Saburov , Ashraf Mohamed Nawi

Several groups have recently modeled evolutionary transitions from an ancestral allele to a beneficial allele separated by one or more intervening mutants. The beneficial allele can become fixed if a succession of intermediate mutants are…

Populations and Evolution · Quantitative Biology 2011-07-14 Stephen R Proulx

The multi-type Moran process is an evolutionary process on a connected graph $G$ in which each vertex has one of $k$ types and, in each step, a vertex $v$ is chosen to reproduce its type to one of its neighbours. The probability of a vertex…

Data Structures and Algorithms · Computer Science 2023-03-15 Leslie Ann Goldberg , Marc Roth , Tassilo Constantin Schwarz

Speciation is fundamental to the huge diversity of life on Earth. Evidence suggests reproductive isolation arises most commonly in allopatry with a higher speciation rate in small populations. Current theory does not address this dependence…

Populations and Evolution · Quantitative Biology 2015-03-27 Bhavin S. Khatri , Richard A. Goldstein

The theory of interaction-based evolution argues that, at the most basic level of analysis, there is a third alternative for how adaptive evolution works besides a) accidental mutation and natural selection and b) Lamarckism, namely, c)…

Populations and Evolution · Quantitative Biology 2016-05-25 Adi Livnat

We are interested in the study of models describing the evolution of a polymorphic population with mutation and selection in the specific scales of the biological framework of adaptive dynamics. The population size is assumed to be large…

Probability · Mathematics 2011-12-05 Nicolas Champagnat , Sylvie Méléard

In large populations, multiple beneficial mutations may be simultaneously spreading. In asexual populations, these mutations must either arise on the same background or compete against each other. In sexual populations, recombination can…

Populations and Evolution · Quantitative Biology 2013-12-19 D. B. Weissman , O. Hallatschek

The model of interaction between learning and evolutionary optimization is designed and investigated. The evolving population of modeled organisms is considered. The mechanism of the genetic assimilation of the acquired features during a…

Neural and Evolutionary Computing · Computer Science 2014-11-20 Vladimir G. Red'ko

We investigate the evolutionary dynamics of a population structured in phenotype, subjected to trait dependent selection with a linearly moving optimum and an asexual mode of reproduction. Our model consists of a non-local and non-linear…

Analysis of PDEs · Mathematics 2021-12-09 Raphaël Forien , Jimmy Garnier , Florian Patout

Commonly recognized evolutionarily relevant effects of sexual reproduction include increased diversity, accelerated adaptation, and constrained accumulation of deleterious mutations, along with a secondary effect of species genotype…

Populations and Evolution · Quantitative Biology 2025-06-17 Assaf Marron , Smadar Szekely , Irun R. Cohen , David Harel