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We consider the sequential experimental design problem in the predict-then-optimize paradigm. In this paradigm, the outputs of the prediction model are used as coefficient vectors in a downstream linear optimization problem. Traditional…

Machine Learning · Statistics 2026-02-06 Beichen Wan , Mo Liu , Paul Grigas , Zuo-Jun Max Shen

We identify locally $D$-optimal crossover designs for generalized linear models. We use generalized estimating equations to estimate the model parameters along with their variances. To capture the dependency among the observations coming…

Methodology · Statistics 2020-01-20 Jeevan Jankar , Abhyuday Mandal , Jie Yang

We study random designs that minimize the asymptotic variance of a de-biased lasso estimator when a large pool of unlabeled data is available but measuring the corresponding responses is costly. The optimal sampling distribution arises as…

Statistics Theory · Mathematics 2020-10-27 Hamid Eftekhari , Moulinath Banerjee , Ya'acov Ritov

The boom of DL technology leads to massive DL models built and shared, which facilitates the acquisition and reuse of DL models. For a given task, we encounter multiple DL models available with the same functionality, which are considered…

Software Engineering · Computer Science 2021-03-10 Linghan Meng , Yanhui Li , Lin Chen , Zhi Wang , Di Wu , Yuming Zhou , Baowen Xu

We characterize $D$-optimal designs in the two-dimensional Poisson regression model with synergetic interaction and provide an explicit proof. The proof is based on the idea of reparameterization of the design region in terms of contours of…

Statistics Theory · Mathematics 2021-06-17 Fritjof Freise , Ulrike Graßhoff , Frank Röttger , Rainer Schwabe

Decision-Focused Learning (DFL) is an emerging learning paradigm that tackles the task of training a machine learning (ML) model to predict missing parameters of an incomplete optimization problem, where the missing parameters are…

Machine Learning · Computer Science 2025-06-23 Yehya Farhat

Optimal block designs for additive models achieve their efficiency by dividing experimental units among relatively homogenous blocks and allocating treatments equally to blocks. Responses in many modern experiments, however, are drawn from…

Methodology · Statistics 2016-01-05 Stephen Bush , Katya Ruggiero

An approach to optimal actuator design based on shape and topology optimisation techniques is presented. For linear diffusion equations, two scenarios are considered. For the first one, best actuators are determined depending on a given…

Optimization and Control · Mathematics 2024-03-06 Dante Kalise , Karl Kunisch , Kevin Sturm

Decision diagrams for classification have some notable advantages over decision trees, as their internal connections can be determined at training time and their width is not bound to grow exponentially with their depth. Accordingly,…

Machine Learning · Computer Science 2022-05-31 Alexandre M. Florio , Pedro Martins , Maximilian Schiffer , Thiago Serra , Thibaut Vidal

Much of the work in the literature on optimal discrimination designs assumes that the models of interest are fully specified, apart from unknown parameters in some models. Recent work allows errors in the models to be non-normally…

Methodology · Statistics 2016-12-06 Holger Dette , Roman Guchenko , Viatcheslav Melas , Weng Kee Wong

Optimal designs are required to make efficient statistical experiments. D-optimal designs for some models are calculated by using canonical moments. On the other hand, integrable systems are dynamical systems whose solutions can be written…

Methodology · Statistics 2012-11-06 Hiroto Sekido

Suppose an online platform wants to compare a treatment and control policy, e.g., two different matching algorithms in a ridesharing system, or two different inventory management algorithms in an online retail site. Standard randomized…

Methodology · Statistics 2022-12-27 Peter Glynn , Ramesh Johari , Mohammad Rasouli

This research is motivated by the need for effective classification in ice-breaking dynamic simulations, aimed at determining the conditions under which an underwater vehicle will break through the ice. This simulation is extremely…

Methodology · Statistics 2025-06-05 Tian Bai , Dianpeng Wang , Kuangqi Chen , Xu He

We consider constrained sampling problems in paid research studies or clinical trials. When qualified volunteers are more than the budget allowed, we recommend a D-optimal sampling strategy based on the optimal design theory and develop a…

Methodology · Statistics 2024-05-27 Yifei Huang , Liping Tong , Jie Yang

Optimal two-treatment, $p$ period crossover designs for binary responses are determined. The optimal designs are obtained by minimizing the variance of the treatment contrast estimator over all possible allocations of $n$ subjects to $2^p$…

Methodology · Statistics 2015-05-12 S. Mukhopadhyay , S. P. Singh , A. Dey

Determining the causal structure of a set of variables is critical for both scientific inquiry and decision-making. However, this is often challenging in practice due to limited interventional data. Given that randomized experiments are…

Methodology · Statistics 2019-02-28 Raj Agrawal , Chandler Squires , Karren Yang , Karthik Shanmugam , Caroline Uhler

In a tie-breaker design (TBD), subjects with high values of a running variable are given some (usually desirable) treatment, subjects with low values are not, and subjects in the middle are randomized. TBDs are intermediate between…

Methodology · Statistics 2025-05-12 Tim P. Morrison , Art B. Owen

Deep Generative Machine Learning Models (DGMs) have been growing in popularity across the design community thanks to their ability to learn and mimic complex data distributions. DGMs are conventionally trained to minimize statistical…

Machine Learning · Computer Science 2022-06-16 Lyle Regenwetter , Faez Ahmed

The paper deals with the problem of output regulation in a "non-equilibrium" context for a special class of multivariable nonlinear systems stabilizable by high-gain feedback. A post-processing internal model design suitable for the…

Systems and Control · Electrical Eng. & Systems 2020-04-22 Michelangelo Bin , Lorenzo Marconi

An increasing number of publications present the joint application of Design of Experiments (DOE) and machine learning (ML) as a methodology to collect and analyze data on a specific industrial phenomenon. However, the literature shows that…

Machine Learning · Statistics 2022-05-20 Rosa Arboretti , Riccardo Ceccato , Luca Pegoraro , Luigi Salmaso