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In this paper we describe the solution of a stochastic bistable system from a dynamical perspective. We show how a single framework with variable noise can explain hysteresis at zero temperature and two-state coexistence in the presence of…

Statistical Mechanics · Physics 2019-11-25 Mahendra K. Verma , Abhishek Kumar , Adhip Pattanayak

Many dynamical systems arising in biology and other areas exhibit multistationarity (two or more positive steady states with the same conserved quantities). Although deciding multistationarity for a polynomial dynamical system is an…

Molecular Networks · Quantitative Biology 2019-02-08 Alicia Dickenstein , Mercedes Perez Millan , Anne Shiu , Xiaoxian Tang

External flows of energy, entropy, and matter can cause sudden transitions in the stability of biological and industrial systems, fundamentally altering their dynamical function. How might we control and design these transitions in chemical…

Molecular Networks · Quantitative Biology 2023-06-19 Zachary G. Nicolaou , Schuyler B. Nicholson , Adilson E. Motter , Jason R. Green

A basic statistical mechanics analysis of many-body systems with non-reciprocal pair interactions is presented. Different non-reciprocity classes in two- and three-dimensional binary systems (relevant to real experimental situations) are…

Statistical Mechanics · Physics 2015-10-09 A. V. Ivlev , J. Bartnick , M. Heinen , H. Löwen

Within systems biology there is an increasing interest in the stochastic behavior of genetic and biochemical reaction networks. An appropriate stochastic description is provided by the chemical master equation, which represents a continuous…

Biological Physics · Physics 2011-06-23 E. Giampieri , D. Remondini , L. de Oliveira , G. Castellani , P. Lió

The understanding of the statistical properties and of the dynamics of multistable systems is gaining more and more importance in a vast variety of scientific fields. This is especially relevant for the investigation of the tipping points…

Atmospheric and Oceanic Physics · Physics 2011-09-06 Valerio Lucarini , Davide Faranda , Matteo Willeit

We study the out-of-equilibrium dynamics of dissipative gases of atoms excited to two or more high-lying Rydberg states. This situation bears interesting similarities to classical binary (in general $p$-ary) mixtures of particles. The…

Quantum Gases · Physics 2016-10-04 Ricardo Gutierrez , Juan P. Garrahan , Igor Lesanovsky

Bistability, or the coexistence of two stable phases, can be broken by a bias field $h$ destabilising one of the phases via the nucleation and growth of defects. Strong long-range interactions, $1/r^\alpha$ with $\alpha$ less than the…

Statistical Mechanics · Physics 2025-06-13 Achilleas Lazarides , Andrea Pizzi

Fluctuating environments pose tremendous challenges to bacterial populations. It is observed in numerous bacterial species that individual cells can stochastically switch among multiple phenotypes for the population to survive in rapidly…

Molecular Networks · Quantitative Biology 2015-01-20 Chen Jia , Min-Ping Qian , Yu Kang , Da-Quan Jiang

A non-equilibrium steady state can be characterized by a nonzero but stationary flux driven by a static external force. Under a weak external force, the drift velocity is difficult to detect because the drift motion is feeble and submerged…

Statistical Mechanics · Physics 2015-06-22 Rui Shi , Yanting Wang

Transitions between multiple stable states of nonlinear systems are ubiquitous in physics, chemistry, and beyond. Two types of behaviors are usually seen as mutually exclusive: unpredictable noise-induced transitions and predictable…

Statistical Mechanics · Physics 2017-10-03 Corentin Herbert , Freddy Bouchet

Chemical reaction networks offer a natural nonlinear generalisation of linear Markov jump processes on a finite state-space. In this paper, we analyse the dynamical large deviations of such models, starting from their microscopic version,…

Statistical Mechanics · Physics 2019-09-04 Alexandre Lazarescu , Tommaso Cossetto , Gianmaria Falasco , Massimiliano Esposito

A system containing a pre-steady state standard (non-autocatalytic) reaction, with multiple paths, evolves toward a kinetic state with the minimum attainable activation free energy. Displacement of the path frequency distribution in this…

Chemical Physics · Physics 2008-02-03 Brian K. Davis

In equilibrium systems with short-ranged interactions, the relative stability of different thermodynamic states generally does not depend on system size (as long as this size is larger than the interaction range). Here, we use a large…

Statistical Mechanics · Physics 2013-05-30 Sorin Tanase-Nicola , David K. Lubensky

Cellular transformations which involve a significant phenotypical change of the cell's state use bistable biochemical switches as underlying decision systems. In this work, we aim at linking cellular decisions taking place on a time scale…

Cell Behavior · Quantitative Biology 2010-05-11 Steffen Waldherr , Jingbo Wu , Frank Allgöwer

What are the signatures of the onset of catastrophe? Here we present the rich system physics characterizing the transition from homeostasis to stochasticity driven breakdown in an experimentally motivated minimal model. Recent…

Statistical Mechanics · Physics 2025-07-09 Rudro R. Biswas , Charles S. Wright , Kunaal Joshi , Srividya Iyer-Biswas

Subharmonic response is a well known phenomena in, e.g., deterministic nonlinear dynamical systems. We investigate the conditions under which such subharmonic oscillations can persist for a long time in open systems with stochastic dynamics…

Statistical Mechanics · Physics 2019-08-15 Lukas Oberreiter , Udo Seifert , Andre C. Barato

We consider a stochastic perturbation of the phase field alpha-Navier-Stokes model with vesicle-fluid interaction. It consists in a system of nonlinear evolution partial differential equations modeling the fluid-structure interaction…

Probability · Mathematics 2019-01-08 Ludovic Goudenège , Luigi Manca

Macroscopic equations arising out of stochastic particle systems in detailed balance (called dissipative systems or gradient flows) have a natural variational structure, which can be derived from the large-deviation rate functional for the…

Mathematical Physics · Physics 2023-10-05 Robert I. A. Patterson , D. R. Michiel Renger , Upanshu Sharma

Subdiffusion has been proposed as an explanation of various kinetic phenomena inside living cells. In order to fascilitate large-scale computational studies of subdiffusive chemical processes, we extend a recently suggested mesoscopic model…

Analysis of PDEs · Mathematics 2018-02-19 Emilie Blanc , Stefan Engblom , Andreas Hellander , Per Lötstedt