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A population quantity of interest in statistical shape analysis is the location of landmarks, which are points that aid in reconstructing and representing shapes of objects. We provide an automated, model-based approach to inferring…
Statistical inference on the mean of a Poisson distribution is a fundamentally important problem with modern applications in, e.g., particle physics. The discreteness of the Poisson distribution makes this problem surprisingly challenging,…
We continue studies of the uncertainty quantification problem in emission tomographies such as PET or SPECT when additional multimodal data (e.g., anatomical MRI images) are available. To solve the aforementioned problem we adapt the…
Filtering and parameter estimation under partial information for multiscale problems is studied in this paper. After proving mean square convergence of the nonlinear filter to a filter of reduced dimension, we establish that the conditional…
We develop a comprehensive model for the effective two-photon density matrix produced by a parametric source of entangled photon pairs under a variety of detector configurations commonly seen in a laboratory setting: two and four photon…
This paper studies the optimal solution of the classical problem of detecting the location of multiple image occurrences in a two-dimensional, noisy measurement. Assuming the image occurrences do not overlap, we formulate this task as a…
Fluorescence microscopy images contain several channels, each indicating a marker staining the sample. Since many different marker combinations are utilized in practice, it has been challenging to apply deep learning based segmentation…
This paper discusses new methods for processing images in the photon-limited regime where the number of photons per pixel is binary. We present a new Bayesian denoising method for binary, single-photon images. Each pixel measurement is…
This work considers a problem of estimating a mixing probability density $f$ in the setting of discrete mixture models. The paper consists of three parts. The first part focuses on the construction of an $L_1$ consistent estimator of $f$.…
In image classification tasks, deep learning models are vulnerable to image distortion. For successful deployment, it is important to identify distortion levels under which the model is usable i.e. its accuracy stays above a stipulated…
The evaluation of the error to be attributed to cut efficiencies is a common question in the practice of experimental particle physics. Specifically, the need to evaluate the efficiency of the cuts for background removal, when they are…
The likelihood ratio is a crucial quantity for statistical inference in science that enables hypothesis testing, construction of confidence intervals, reweighting of distributions, and more. Many modern scientific applications, however,…
A universal and optimal method for the polarimetry of light with arbitrary photon statistics is presented. The method is based on the continuous maximum-likelihood positive operator-valued measure (ML-POVM) for pure polarization states over…
Contemporary approaches frame the color constancy problem as learning camera specific illuminant mappings. While high accuracy can be achieved on camera specific data, these models depend on camera spectral sensitivity and typically exhibit…
Conventional wisdom dictates that to image the position of fluorescent atoms or molecules, one should stimulate as much emission and collect as many photons as possible. That is, in this classical case, it has always been assumed that the…
Single-particle imaging experiments of biomolecules at x-ray free-electron lasers (XFELs) require processing of hundreds of thousands (or more) of images that contain very few x-rays. Each low-flux image of the diffraction pattern is…
We revisit the problem of estimating the parameters of a partially observed diffusion process, consisting of a hidden state process and an observed process, with a continuous time parameter. The estimation is to be done online, i.e. the…
Analysis of microscope images is a tedious work which requires patience and time, usually done manually by the microscopist after data collection. Here we introduce an approach of automatic image analysis, which is based on locally applied…
Although some non-trivial photon number resolving detectors exist, it may still be convenient to discriminate photon number states with the method of multiplexed detection. Multiplexing can be performed with paths in real space, with paths…
Many cosmological models have only a finite number of parameters of interest, but a very expensive data-generating process and an intractable likelihood function. We address the problem of performing likelihood-free Bayesian inference from…