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Sorting a permutation by reversals is a famous problem in genome rearrangements. Since 1997, quite some biological evidence were found that in many genomes the reversed regions are usually flanked by a pair of inverted repeats. This type of…

Data Structures and Algorithms · Computer Science 2023-02-09 Xin Tong , Yixiao Yu , Ziyi Fang , Haitao Jiang , Lusheng Wang , Binhai Zhu , Daming Zhu

In the context of the genome rearrangement problem, we analyze two well known models, namely the block transposition and the prefix block transposition models, by exploiting the connection with the notion of permutation pattern. More…

Combinatorics · Mathematics 2018-08-09 Giulio Cerbai , Luca Ferrari

Given a graph where every vertex has exactly one labeled token, how can we most quickly execute a given permutation on the tokens? In (sequential) token swapping, the goal is to use the shortest possible sequence of swaps, each of which…

Genome rearrangement distances are an established method in genome comparison. Works in this area may include various rearrangement operations representing large-scale mutations, gene orientation information, the number of nucleotides in…

Data Structures and Algorithms · Computer Science 2026-01-01 Gabriel Siqueira , Alexsandro Oliveira Alexandrino , Zanoni Dias

Genomic distance between two genomes, i.e., the smallest number of genome rearrangements required to transform one genome into the other, is often used as a measure of evolutionary closeness of the genomes in comparative genomics studies.…

Genomics · Quantitative Biology 2011-03-30 Shuai Jiang , Max A. Alekseyev

We address the problem of finding the minimum decomposition of a permutation in terms of transpositions with non-uniform cost. For arbitrary non-negative cost functions, we describe polynomial-time, constant-approximation decomposition…

Information Theory · Computer Science 2010-07-27 Farzad Farnoud , Olgica Milenkovic

On the string of finite length, a (genomic) transposition is defined as the operation of exchanging two consecutive substrings. The minimum number of transpositions needed to transform one into the other is the transposition distance, that…

Combinatorics · Mathematics 2025-01-29 Misa Nakanishi

Genome assembly, the process of reconstructing a long genetic sequence by aligning and merging short fragments, or reads, is known to be NP-hard, either as a version of the shortest common superstring problem or in a Hamiltonian-cycle…

Statistical Mechanics · Physics 2024-03-12 L. A. Fernandez , V. Martin-Mayor , D. Yllanes

Understanding the evolution of a set of genes or species is a fundamental problem in evolutionary biology. The problem we study here takes as input a set of trees describing {possibly discordant} evolutionary scenarios for a given set of…

Data Structures and Algorithms · Computer Science 2019-07-10 Cedric Chauve , Mark Jones , Manuel Lafond , Céline Scornavacca , Mathias Weller

We prove a lower and an upper bound on the number of block moves necessary to sort a permutation. We put our results in contrast with existing results on sorting by block transpositions, and raise some open questions.

Combinatorics · Mathematics 2008-06-18 Miklos Bona , Ryan Flynn

We study complexity of rearrangement problems in the generalized breakpoint model and settle several open questions. The model was introduced by Tannier et al. (2009) who showed that the median problem is solvable in polynomial time in the…

Discrete Mathematics · Computer Science 2013-01-11 Jakub Kovac

Perfect sorting by reversals, a problem originating in computational genomics, is the process of sorting a signed permutation to either the identity or to the reversed identity permutation, by a sequence of reversals that do not break any…

Discrete Mathematics · Computer Science 2012-01-05 Mathilde Bouvel , Cedric Chauve , Marni Mishna , Dominique Rossin

A permutation on an alphabet $ \Sigma $, is a sequence where every element in $ \Sigma $ occurs precisely once. Given a permutation $ \pi $= ($\pi_{1} $, $ \pi_{2} $, $ \pi_{3} $,....., $ \pi_{n} $) over the alphabet $ \Sigma $ =$\{ $0, 1,…

Discrete Mathematics · Computer Science 2016-01-19 Bhadrachalam Chitturi , Krishnaveni K S

We address the problem of finding the minimal number of block interchanges (exchange of two intervals) required to transform a duplicated linear genome into a tandem duplicated linear genome. We provide a formula for the distance as well as…

Data Structures and Algorithms · Computer Science 2011-07-07 Antoine Thomas , Aïda Ouangraoua , Jean-Stéphane Varré

We initiate the study of sorting permutations using prefix block-interchanges, which exchange any prefix of a permutation with another non-intersecting interval. The goal is to transform a given permutation into the identity permutation…

Data Structures and Algorithms · Computer Science 2022-08-29 Anthony Labarre

Sorting a Permutation by Transpositions (SPbT) is an important problem in Bioinformtics. In this paper, we improve the running time of the best known approximation algorithm for SPbT. We use the permutation tree data structure of Feng and…

Data Structures and Algorithms · Computer Science 2009-10-20 Jesun Sahariar Firoz , Masud Hasan , Ashik Zinnat Khan , M. Sohel Rahman

We prove that computing an evolutionary ordering of a family of sets, i.e. an ordering where each set intersects with --but is not included in-- the union earlier sets, is NP-hard.

Computational Complexity · Computer Science 2014-10-27 Laurent Bulteau , Gustavo Sacomoto , Blerina Sinaimeri

We continue the study of Adin, Alon and Roichman [arXiv:2502.14398, 2025] on the number of steps required to sort $n$ labelled points on a circle by transpositions. Imagine that the vertices of a cycle of length $n$ are labelled by the…

Combinatorics · Mathematics 2025-11-04 Paul Bastide , Anurag Bishnoi , Carla Groenland , Dion Gijswijt , Rohinee Joshi

In this article, we study the problem of finding the longest common separable pattern between several permutations. We give a polynomial-time algorithm when the number of input permutations is fixed and show that the problem is NP-hard for…

Combinatorics · Mathematics 2007-06-13 Mathilde Bouvel , Dominique Rossin , Stephane Vialette

A ternary permutation constraint satisfaction problem (CSP) is specified by a subset Pi of the symmetric group S_3. An instance of such a problem consists of a set of variables V and a set of constraints C, where each constraint is an…

Computational Complexity · Computer Science 2014-10-10 Leo van Iersel , Steven Kelk , Nela Lekic , Simone Linz