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The evolution of antimicrobial resistance generally occurs in an environment where antimicrobial concentration is variable, which has dramatic consequences on the microorganisms' fitness landscape, and thus on the evolution of resistance.…

Biological Physics · Physics 2018-10-23 Loïc Marrec , Anne-Florence Bitbol

Macroevolution is considered as a problem of stochastic dynamics in a system with many competing agents. Evolutionary events (speciations and extinctions) are triggered by fitness records found by random exploration of the agents' fitness…

adap-org · Physics 2017-01-11 Paolo Sibani , Michael Brandt , Preben Alstroem

The spread of an epidemic disease and the population's collective behavioural response are deeply intertwined, influencing each other's evolution. Such a co-evolution typically has been overlooked in mathematical models, limiting their…

Dynamical Systems · Mathematics 2024-10-24 Kathinka Frieswijk , Lorenzo Zino , Mengbin Ye , Alessandro Rizzo , Ming Cao

The adaptation rate in theoretical models of biological evolution increases with the mutation rate but only to a point when mutations into lethal states cause extinction. One would expect that removing such states should be beneficial for…

Populations and Evolution · Quantitative Biology 2024-06-27 Viktoria Blavatska , Bartlomiej Waclaw

The adaptation process of a species to a new environment is a significant area of study in biology. As part of natural selection, adaptation is a mutation process which improves survival skills and reproductive functions of species. Here,…

Populations and Evolution · Quantitative Biology 2017-10-27 Maria Kleshnina , Jerzy A. Filar , Vladimir Ejov , Jody C. McKerral

We investigate the evolution of quiescence within the framework of Adaptive Dynamics for an SIQS (Susceptible - Infected - Quiescent) model with constant environment. In the first part of the paper, the competition of two strains which have…

Populations and Evolution · Quantitative Biology 2025-07-14 Leonard Braun , Noah Risse , Aurélien Tellier , Johannes Müller

Epidemic spreading often occurs in spatially heterogeneous environments, yet how quenched heterogeneity reshapes its onset and critical dynamics remains poorly understood. The diffusive epidemic process, a minimal reaction-diffusion model…

Statistical Mechanics · Physics 2026-03-24 Valentin Anfray , Hong-Yan Shih

For many infectious disease outbreaks, the at-risk population changes their behavior in response to the outbreak severity, causing the transmission dynamics to change in real-time. Behavioral change is often ignored in epidemic modeling…

Methodology · Statistics 2023-10-25 Caitlin Ward , Rob Deardon , Alexandra M. Schmidt

We show that a simple evolutionary scheme, when applied to the minority game (MG), changes the phase structure of the game. In this scheme each agent evolves individually whenever his wealth reaches the specified bankruptcy level, in…

Statistical Mechanics · Physics 2009-11-10 Baosheng Yuan , Kan Chen

Predicting the adaptation of populations to a changing environment is crucial to assess the impact of human activities on biodiversity. Many theoretical studies have tackled this issue by modeling the evolution of quantitative traits…

Analysis of PDEs · Mathematics 2022-06-28 Jimmy Garnier , O Cotto , T Bourgeron , E Bouin , T Lepoutre , O Ronce , V Calvez

Frequency-dependent selection reflects the interaction between different species as they battle for limited resources in their environment. In a stochastic evolutionary game the species relative fitnesses guides the evolutionary dynamics…

Probability · Mathematics 2020-12-29 Lea Popovic , Liam Peuckert

The global impact of the COVID-19 pandemic on the livelihoods of people worldwide prompted the implementation of a range of preventive measures at local, national, and international levels. Early in the outbreak, before the vaccine became…

Physics and Society · Physics 2025-01-03 Pranav Verma , Viney Kumar , Samit Bhattacharyya

These lectures contain a brief description of evolutionary models inspired by the statistical mechanics of disordered systems. After an introduction describing the Darwinian paradigm of evolving populations, the deterministic quasispecies…

Disordered Systems and Neural Networks · Physics 2007-05-23 Luca Peliti

RNA viruses are a widely used tool to study evolution experimentally. Many standard protocols of virus propagation and competition are done at nominally low multiplicity of infection (m.o.i.), but lead during one passage to two or more…

Populations and Evolution · Quantitative Biology 2007-05-23 Claus O. Wilke , Daniel D. Reissig , Isabel S. Novella

Diseases emerge, persist and vanish in an ongoing battle for available hosts. Hosts, on the other hand, defend themselves by developing immunity that limits the ability of pathogens to reinfect them. We here explore a multi-disease system…

Adaptation and Self-Organizing Systems · Physics 2012-06-29 Jeppe Juul , Kim Sneppen

The quasispecies model describes processes related to the origin of life and viral evolutionary dynamics. We discuss how the error catastrophe that reflects the transition from localized to delocalized quasispecies population is affected by…

Populations and Evolution · Quantitative Biology 2009-12-31 Nathaniel Wagner , Emmanuel Tannenbaum , Gonen Ashkenasy

The evolutionary dynamics of human Influenza A virus presents a challenging theoretical problem. An extremely high mutation rate allows the virus to escape, at each epidemic season, the host immune protection elicited by previous…

Populations and Evolution · Quantitative Biology 2016-11-30 Lorenzo Taggi , Francesca Colaiori , Vittorio Loreto , Francesca Tria

We study the stochastic dynamics of evolutionary games, and focus on the so-called `stochastic slowdown' effect, previously observed in (Altrock et. al, 2010) for simple evolutionary dynamics. Slowdown here refers to the fact that a…

Populations and Evolution · Quantitative Biology 2012-07-30 Philipp M. Altrock , Arne Traulsen , Tobias Galla

After more than 6 million deaths worldwide, the ongoing vaccination to conquer the COVID-19 disease is now competing with the emergence of increasingly contagious mutations, repeatedly supplanting earlier strains. Following the near-absence…

Populations and Evolution · Quantitative Biology 2022-05-09 Fabian Jan Schwarzendahl , Jens Grauer , Benno Liebchen , Hartmut Löwen

We demonstrate with a thought experiment that fitness-based population dynamical approaches to evolution are not able to make quantitative, falsifiable predictions about the long-term behavior of evolutionary systems. A key characteristic…

Populations and Evolution · Quantitative Biology 2015-05-14 Peter Klimek , Stefan Thurner , Rudolf Hanel