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The fluid dynamics video that is presented here outlines recent advances in the simulation of multiphase cellular blood flow through the direct numerical simulations of deformable red blood cells (RBCs) demonstrated through several…

Fluid Dynamics · Physics 2009-10-20 Jonathan R. Clausen , Daniel A. Reasor , Cyrus K. Aidun

Red blood cells (RBCs) are an essential component of blood. A method to include the particulate nature of blood is introduced here with the goal of studying circulation in large-scale realistic vessels. The method uses a combination of the…

Medical Physics · Physics 2011-07-26 Simone Melchionna

We investigate the dynamics of the Red Blood Cell (RBC) in microfluidic channels under oscillatory flows. The simulations employ a hybrid continuum-particle approach, in which the cell membrane and cytosol fluid are modeled using…

Fluid Dynamics · Physics 2023-07-18 Lahcen Akerkouch , Trung Bao Le

High-resolution blood flow simulations have potential for developing better understanding biophysical phenomena at the microscale, such as vasodilation, vasoconstriction and overall vascular resistance. To this end, we present a scalable…

Computational Engineering, Finance, and Science · Computer Science 2019-09-26 Libin Lu , Matthew J. Morse , Abtin Rahimian , Georg Stadler , Denis Zorin

The multi-cellular hydrodynamic interactions play a critical role in the phenomenology of blood flow in the microcirculation. A fast algorithm has been developed to simulate large numbers of cells modeled as elastic thin membranes. For red…

Fluid Dynamics · Physics 2008-10-14 Amir H. G. Isfahani , Hong Zhao , Jonathan B. Freund

Interfaces between two fluids are ubiquitous and of special importance for industrial applications, e.g., stabilisation of emulsions. The dynamics of fluid-fluid interfaces is difficult to study because these interfaces are usually…

Soft Condensed Matter · Physics 2015-03-20 Timm Krüger , Stefan Frijters , Florian Günther , Badr Kaoui , Jens Harting

We present a computational framework for the simulation of blood flow with fully resolved red blood cells (RBCs) using a modular approach that consists of a lattice Boltzmann solver for the blood plasma, a novel finite element based solver…

Computational Physics · Physics 2019-08-28 Christos Kotsalos , Jonas Latt , Bastien Chopard

Computational modeling and simulation are presented on the motion of red blood cells behind a moving interface in a capillary. The methodology is based on an immersed boundary method and the skeleton structure of the red blood cell (RBC)…

Fluid Dynamics · Physics 2013-04-16 Shihai Zhao , Tsorng-Whay Pan

We propose a modified suspension balance model (SBM) for the flow of red blood cells (RBCs) and other deformable particle suspensions in confined geometries. Specifically, the method includes the hydrodynamic lift force generated by…

With the rapid development of studies involving droplet microfluidics, drug delivery, cell detection, and microparticle synthesis, among others, many scientists have invested significant efforts to model the flow of these fluid-filled…

Many numerical studies of blood flow impose a rigid wall assumption due to the simplicity of its implementation compared to a full coupling to a solid mechanics model. In this paper, we present a localised method for incorporating the…

Fluid Dynamics · Physics 2021-08-20 J. W. S. McCullough , P. V. Coveney

Red blood cells flowing through capillaries assume a wide variety of different shapes owing to their high deformability. Predicting the realized shapes is a complex field as they are determined by the intricate interplay between the flow…

Biological Physics · Physics 2017-11-21 Achim Guckenberger , Alexander Kihm , Thomas John , Christian Wagner , Stephan Gekle

We study the deformation and motion of an erythrocyte in fluid flows via a lattice Boltzmann method. To this purpose, the bending rigidity and the elastic modulus of isotropic dilation are introduced and incorporated with the lattice…

Fluid Dynamics · Physics 2007-05-23 Huabing Li , Houhui Yi , Xiaowen Shan , Haiping Fang

This paper presents a model for the simulation of liquid-gas-solid flows by means of the lattice Boltzmann method. The approach is built upon previous works for the simulation of liquid-solid particle suspensions on the one hand, and on a…

Computational Engineering, Finance, and Science · Computer Science 2014-01-08 Simon Bogner , Ulrich Rüde

Computational Fluid Dynamics (CFD) is currently used to design and improve the hydraulic properties of biomedical devices, wherein the large scale blood circulation needs to be simulated by accounting for the mechanical response of red…

Fluid Dynamics · Physics 2024-12-24 F. Guglietta , M. Behr , L. Biferale , G. Falcucci , M. Sbragaglia

We present a rigorous procedure to derive coarse-grained red blood cell (RBC) models, which lead to accurate mechanical properties of realistic RBCs. Based on a semi-analytic theory linear and non-linear elastic properties of the RBC…

Cell Behavior · Quantitative Biology 2009-05-04 Dmitry A. Fedosov , Bruce Caswell , George E. Karniadakis

We present a novel lattice Boltzmann method that has a capability of simulating thermodynamic multiphase flows. This approach is fully thermodynamically consistent at the macroscopic level. Using this new method, a liquid-vapor boiling…

Fluid Dynamics · Physics 2009-11-07 Raoyang Zhang , Hudong Chen

A numerical method for simulating three-phase flows with moving contact lines on arbitrarily complex surfaces is developed in the framework of lattice Boltzmann method. In this method, the immiscible three-phase flow is modeled through a…

Fluid Dynamics · Physics 2021-07-28 Sheng Li , Yang Lu , Fei Jiang , Haihu Liu

The deformability of human red blood cells (RBCs), which comprise almost 99% of the cells in whole blood, is largely related not only to pathophysiological blood flow but also to the levels of intracellular compounds. Therefore, statistical…

The study of vesicles under flow, a model system for red blood cells (RBCs), is an essential step in understanding various intricate dynamics exhibited by RBCs in vivo and in vitro. Quantitative 3D analyses of vesicles under flow are…

Soft Condensed Matter · Physics 2009-12-24 Thierry Biben , Alexander Farutin , Chaouqi Misbah
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