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The maintenance of the proliferative cell niche is critical to epithelial tissue morphology and function. In this paper we investigate how current modelling methods can result in the erroneous loss of proliferative cells from the…

Tissues and Organs · Quantitative Biology 2021-09-01 Claire Miller , Edmund Crampin , James Osborne

Evolution occurs in populations of reproducing individuals. The structure of a biological population affects which traits evolve. Understanding evolutionary game dynamics in structured populations is difficult. Precise results have been…

Populations and Evolution · Quantitative Biology 2017-08-16 Benjamin Allen , Gabor Lippner , Yu-Ting Chen , Babak Fotouhi , Naghmeh Momeni , Martin A. Nowak , Shing-Tung Yau

Understanding how stochastic and non-linear deterministic processes interact is a major challenge in population dynamics theory. After a short review, we introduce a stochastic individual-centered particle model to describe the evolution in…

Probability · Mathematics 2009-06-29 Regis Ferriere , Viet Chi Tran

Pattern forming systems allow for a wealth of states, where wavelengths and orientation of patterns varies and defects disrupt patches of monocrystalline regions. Growth of patterns has long been recognized as a strong selection mechanism.…

Pattern Formation and Solitons · Physics 2023-02-28 Ryan Goh , Arnd Scheel

This research paper talks about using complex mathematical tools to study and figure out the behavior of biological populations in porous media. Porous media offer a unique environment where various factors, including fluid flow and…

Analysis of PDEs · Mathematics 2024-12-10 Urvashi Joshi , Aniruddha Kumar Sharma , Rajan Arora

I study a population model in which the reproduction rate lambda is inherited with mutation, favoring fast reproducers in the short term, but conflicting with a process that eliminates agglomerations of individuals. The model is a variant…

Statistical Mechanics · Physics 2021-06-02 Ronald Dickman

Cell invasion and spatial pattern formation are two distinct manifestations of cellular self-organisation in development, regeneration, and disease. Here, we develop and analyse a unified theoretical framework that links these two seemingly…

Tissues and Organs · Quantitative Biology 2026-04-30 Carles Falcó , Samuel W. S. Johnson , Mohit P. Dalwadi , Philip K. Maini

Recent studies have shown that even in the absence of extrinsic stress, the morphologically symmetrically dividing model bacteria Escherichia coli do not generate offspring with equal reproductive fitness. Instead, daughter cells exhibit…

Populations and Evolution · Quantitative Biology 2020-01-01 Natasha Blitvić , Vicente I. Fernandez

In this paper, we discuss the asymptotic behaviour of weak solutions to the Cauchy problem toward the viscous shock waves for the scalar viscous conservation law. We firstly consider the case that the flux function is the quadratic Burgers…

Analysis of PDEs · Mathematics 2023-12-07 Yechi Liu

Developing epithelial tissues coordinate cell proliferation and mechanical forces to achieve proper size and shape. As epithelial cells tightly adhere together to form the confluent tissue, the distribution of cell areas significantly…

Biological Physics · Physics 2026-01-22 Michael F. Staddon , Natalie A. Dye , Marko Popović , Frank Jülicher

Existence of strong solutions of an abstract Cauchy problem for a class of doubly nonlinear evolution inclusion of second order is established via a semi-implicit time discretization method. The principal parts of the operators acting on…

Analysis of PDEs · Mathematics 2022-04-29 Aras Bacho

The Batchelor passive advection is an advection by a smooth velocity field. If the velocity field is a delta-correlated in time random Gaussian process, then the problem is reduced to quantum mechanics of fluctuating velocity gradient…

Astrophysics · Physics 2007-05-23 S. Boldyrev

This paper develops a quasispecies model where cells can adopt a two-cell survival strategy. Within this strategy, pairs of cells join together, at which point one of the cells sacrifices its own replicative ability for the sake of the…

Populations and Evolution · Quantitative Biology 2009-11-11 Emmanuel Tannenbaum

Cell reproduction involves replication of diverse molecule species, in contrast to simple replication system with fewer components. Here, we address why such diversity is sustained despite the efficiency of simple replication systems, using…

Cell Behavior · Quantitative Biology 2016-07-06 Atsushi Kamimura , Kunihiko Kaneko

Continuum models for the spatial dynamics of growing cell populations have been widely used to investigate the mechanisms underpinning tissue development and tumour invasion. These models consist of nonlinear partial differential equations…

Tissues and Organs · Quantitative Biology 2019-07-15 Mark AJ Chaplain , Tommaso Lorenzi , Fiona R Macfarlane

The parabolic Anderson model is the Cauchy problem for the heat equation with a random potential. We consider this model in a setting which is continuous in time and discrete in space, and focus on time-constant, independent and identically…

Probability · Mathematics 2009-10-30 Peter Mörters , Marcel Ortgiese , Nadia Sidorova

We propose a type-dependent branching model with mutation and competition for modeling phylogenies of a virus population. The competition kernel depends for any two virus particles on the particles' types, the total mass of the population…

Probability · Mathematics 2017-05-10 Sandra Kliem , Anita Winter

In this work we model the dynamics of a population that evolves as a continuous time branching process with a trait structure and ecological interactions in form of mutations and competition between individuals. We generalize existing…

Probability · Mathematics 2020-10-19 Gabriel Berzunza , Anja Sturm , Anita Winter

The rate at which individual bacterial cells grow depends on the concentrations of cellular components such as ribosomes and proteins. These concentrations continuously fluctuate over time and are inherited from mother to daughter cells,…

Populations and Evolution · Quantitative Biology 2024-08-21 Yaïr Hein , Farshid Jafarpour

A two-type two-sex branching process is introduced with the aim of describing the interaction of predator and prey populations with sexual reproduction and promiscuous mating. In each generation and in each species the total number of…

Populations and Evolution · Quantitative Biology 2021-01-29 Cristina Gutierrez , Carmen Minuesa