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$^{18}$F-Fluoromisonidazole ($^{18}$F-FMISO) is a highly promising positron emission tomography radiopharmaceutical for identifying hypoxic regions in solid tumors. This research employs spatiotemporal multi-scale mathematical modeling to…

Biological Physics · Physics 2024-05-08 Mohammad Amin Abazari , M. Soltani , Faezeh Eydi , Arman Rahmim , Farshad Moradi Kashkooli

Many real-world networks, ranging from subway systems to polymer structures and fungal mycelia, do not form by the incremental addition of individual nodes but instead grow through the successive extension and intersection of lines or…

Physics and Society · Physics 2026-01-14 Marc Barthelemy

The cytoskeleton in eukaryotic cells plays several crucial roles. In terms of intracellular transport, motor proteins use the cytoskeletal filaments as a backbone along which they can actively transport biological cargos such as vesicles…

Biological Physics · Physics 2020-06-20 Adélaïde Raguin , Norbert Kern , Andrea Parmeggiani

One of the aims of systems biology is to build multiple layered and multiple scale models of living systems which can efficiently describe phenomena occurring at various level of resolution. Such models should consist of layers of various…

Dynamical Systems · Mathematics 2015-03-03 Jacek Banasiak , Aleksandra Falkiewicz , Proscovia Namayanja

Internet, social media, neuronal or blood vessel are organized in complex networks. These networks are characterized by several quantities such as the underlying graph connectivity (topology), how they grow in time, scaling laws or by the…

Subcellular Processes · Quantitative Biology 2018-10-18 Matteo Dora , David Holcman

The elasticity of disordered and polydisperse polymer networks is a fundamental problem of soft matter physics that is still open. Here, we self-assemble polymer networks via simulations of a mixture of bivalent and tri- or tetravalent…

It is well established that the parasites of the genus Leishmania exhibit complex surface interactions with the sandfly vector midgut epithelium, but no prior study has considered the details of their hydrodynamics. Here, the boundary…

Biological Physics · Physics 2018-12-10 Benjamin J. Walker , Richard J. Wheeler , Kenta Ishimoto , Eamonn A. Gaffney

Graph-based representation approaches have been proven to be successful in the analysis of biomedical data, due to their capability of capturing intricate dependencies between biological entities, such as the spatial organization of…

Machine Learning · Computer Science 2023-10-11 Manuel Madeira , Dorina Thanou , Pascal Frossard

How do non-neural organisms, such as the slime mould \textit{Physarum polycephalum}, anticipate periodic events in their environment? We present a minimal, biologically inspired reservoir model that demonstrates simple temporal anticipation…

Neurons and Cognition · Quantitative Biology 2025-05-06 Polyphony Bruna , Linnéa Gyllingberg

Filamentous cyanobacteria can show fascinating examples of nonequilibrium self-organization, which however are not well-understood from a physical perspective. We investigate the motility and collective organization of colonies of these…

Soft Condensed Matter · Physics 2023-10-20 Mixon K. Faluweki , Jan Cammann , Marco G. Mazza , Lucas Goehring

In this paper we suggest that, under suitable conditions, supervised learning can provide the basis to formulate at the microscopic level quantitative questions on the phenotype structure of multicellular organisms. The problem of…

Molecular Networks · Quantitative Biology 2012-06-14 D. Napoletani , E. Petricoin , D. C. Struppa

During phloem unloading, multiple cell-to-cell transport events move organic substances to the root meristem. Although the primary unloading event from the sieve elements to the phloem pole pericycle has been characterized to some extent,…

Many biological networks grow by elongation of filaments that can branch and fuse -- typical examples include fungal mycelium or slime mold. These networks must simultaneously perform multiple tasks such as transport, exploration, and…

Adaptation and Self-Organizing Systems · Physics 2026-01-08 Maxime Lucas , Corentin Bisot , Giovanni Petri , Stéphane Declerck , Timoteo Carletti

We employ a percolation technique developed for pointwise distributions to analyze two-dimensional projections of the three northern and three southern slices in the Las Campanas Redshift Survey. One of the goals of this paper is to compare…

Astrophysics · Physics 2010-10-28 Sergei F. Shandarin , Capp Yess

Understanding the gypsum (CaSO4.2H2O) formation pathway from aqueous solution has been the subject of intensive research in the past years. This interest stems from the fact that gypsum appears to fall into a broader category of crystalline…

Phyllotactic patterns, i.e. regular arrangements of leaves or seeds around a plant stem, are fascinating examples of complex structures encountered in Nature. In botany, their symmetries develop when a new primordium periodically grows in…

Chemical Physics · Physics 2024-10-03 Giulio Facchini , Marcello Budroni , Gabor Schuszter , Fabian Brau , Anne De Wit

The effective mixing behavior of solutes in porous media is fundamentally connected to the development of a local mixing interface between the two initial solutions, which is characterized by a complex lamellar structure. The deformation of…

Fluid Dynamics · Physics 2025-02-28 Daniel M C Hallack , Guillem Sole-Mari , Saif Farhat , Diogo Bolster

The mycelium of a filamentous fungus is a growing, branching network of numerous entangled hyphae exhibiting polarised apical growth. Expansion occurs during the vegetative phase from a single ascospore, driven by the need to explore and…

Quantitative Methods · Quantitative Biology 2026-04-02 Thibault Chassereau , Florence Chapeland-Leclerc , Eric Herbert

Highly-optimized complex transport networks serve crucial functions in many man-made and natural systems such as power grids and plant or animal vasculature. Often, the relevant optimization functional is non-convex and characterized by…

Biological Physics · Physics 2016-09-23 Henrik Ronellenfitsch , Eleni Katifori

Starting from a particle model we derive a macroscopic aggregation-diffusion equation for the evolution of slime mold under the assumption of propagation of chaos in the large particle limit. We analyze properties of the macroscopic model…

Adaptation and Self-Organizing Systems · Physics 2020-06-09 Simone Göttlich , Stephen Knapp , Dylan Weber
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