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We address the relationship between membrane microheterogeneity and anomalous subdiffusion in cell membranes by carrying out Monte Carlo simulations of two-component lipid membranes. We find that near-critical fluctuations in the membrane…

Biological Physics · Physics 2011-04-29 Jens Ehrig , Eugene P. Petrov , Petra Schwille

We propose a minimal model for miscibility phase transitions (MPTs) in a class of asymmetric two-component heterogeneous fluid membranes at equilibrium that generically display both first and second order MPTs, controlled by the interplay…

Soft Condensed Matter · Physics 2015-09-15 Niladri Sarkar , Abhik Basu

Lipid phase heterogeneity in the plasma membrane is thought to be crucial for many aspects of cell signaling, but the physical basis of participating membrane domains such as "lipid rafts" remains controversial. Here we consider a lattice…

Biological Physics · Physics 2018-02-23 Eshan D. Mitra , Samuel C. Whitehead , David Holowka , Barbara Baird , James P. Sethna

To explain the appearance of heterogeneities in the plasma membrane, I propose a hypothesis which begins with the observation that fluctuations in the membrane curvature are coupled to the difference between compositions in one leaf and the…

Soft Condensed Matter · Physics 2017-08-23 M. Schick

We propose a model for membrane-cortex adhesion which couples membrane deformations, hydrodynamics and kinetics of membrane-cortex ligands. In its simplest form, the model gives explicit predictions for the critical pressure for membrane…

Biological Physics · Physics 2016-02-10 Ricard Alert , Jaume Casademunt , Jan Brugués , Pierre Sens

Lateral organization in the plane of the plasma membrane is an important driver of biological processes. The past dozen years have seen increasing experimental support for the notion that lipid organization plays an important role in…

Biological Physics · Physics 2020-09-03 Thomas R. Shaw , Subhadip Ghosh , Sarah L. Veatch

Many of the processes that underly neural computation are carried out by ion channels embedded in the plasma membrane, a two-dimensional liquid that surrounds all cells. Recent experiments have demonstrated that this membrane is poised…

Biological Physics · Physics 2016-07-26 Ofer Kimchi , Sarah L. Veatch , Benjamin B. Machta

We perform an analytical investigation of the cell interface dynamics in the framework of a minimal phase field model of cell motility suggested in [1], which consists of two coupled evolution equations for the order parameter and a…

Biological Physics · Physics 2019-10-04 Mohammad Abu Hamed , Alexander A. Nepomnyashchy

We propose and analyze a model for phase transitions in an inhomogeneous fluid membrane, that couples local composition with curvature nonlinearly. For asymmetric membranes, our model shows generic non-Ising behavior and the ensuing phase…

Soft Condensed Matter · Physics 2015-06-17 Niladri Sarkar , Abhik Basu

We analyze both the static and dynamic fluctuation spectrum of the red-blood cell in a unified manner, using a simple model of the composite membrane. In this model, the two-dimensional spectrin network that forms the cytoskeleton is…

Soft Condensed Matter · Physics 2007-05-23 N. Gov , A. G. Zilman , S. Safran

Membranes containing a wide variety of ternary mixtures of high chain-melting temperature lipids, low chain-melting temperature lipids, and cholesterol undergo lateral phase separartion into coexisting liquid phases at a miscibility…

We extend recent results on the exact hydrodynamics of a system of diffusive active particles displaying a motility-induced phase separation to account for typical fluctuations of the dynamical fields. By calculating correlation functions…

Statistical Mechanics · Physics 2021-08-26 Tal Agranov , Sunghan Ro , Yariv Kafri , Vivien Lecomte

Facilitated spin models on random graphs provide an ideal microscopic realization of the mode-coupling theory of supercooled liquids: they undergo a purely dynamic glass transition with no thermodynamic singularity. In this paper we study…

Statistical Mechanics · Physics 2015-06-11 Silvio Franz , Mauro Sellitto

We study the effects of thermal fluctuations on symmetric tensionless heterogeneous (two-component) fluid membranes in a simple minimal model. Close to the critical point $T_c$ of the associated miscibility phase transition of the…

Statistical Mechanics · Physics 2015-06-23 Tirthankar Banerjee , Abhik Basu

We study fluctuations of the empirical processes of a non-equilibrium interacting particle system consisting of two species over a domain that is recently introduced in [8] and establish its functional central limit theorem. This…

Probability · Mathematics 2021-01-12 Zhen-Qing Chen , Wai-Tong Louis Fan

We theoretically investigate the membrane fluctuations of red blood cells with focus laid on the role of the cytoskeleton, viewing the system as a membrane coupled to sparse spring network. This model is exactly solvable and enables us to…

Soft Condensed Matter · Physics 2015-08-31 Wonjune Choi , Juyeon Yi , Yong Woon Kim

A broad range of membrane proteins display anomalous diffusion on the cell surface. Different methods provide evidence for obstructed subdiffusion and diffusion on a fractal space, but the underlying structure inducing anomalous diffusion…

Biological Physics · Physics 2017-03-15 Sanaz Sadegh , Jenny L. Higgins , Patrick C. Mannion , Michael M. Tamkun , Diego Krapf

We continue the study initiated in [arXiv:1708.02252] of the fluctuations of a strongly-coupled non-conformal plasma described holographically by Einstein gravity coupled to a dilaton with an exponential potential. The plasma approaches a…

High Energy Physics - Theory · Physics 2020-05-06 Panagiotis Betzios , Umut Gürsoy , Matti Järvinen , Giuseppe Policastro

Liquid-liquid phase separation has recently emerged as an important topic in the context of cellular organization. Within this context, there are multiple poorly understood features; for instance hints of critical behavior in the plasma…

Statistical Mechanics · Physics 2024-06-25 Felix Herrmann , Burkhard Dünweg , Martin Girard

In a cellular medium, the plasmic membrane is a place of interactions between the cell and its direct external environment. A classic model describes it as a fluid mosaic. The fluid phase of the membrane allows a lateral degree of freedom…

Probability · Mathematics 2013-09-24 Aimé Lachal
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