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In Diffusive Molecular Communication (DMC), information is transmitted by diffusing molecules. Synaptic signaling is a natural implementation of this paradigm. It is responsible for relaying information from one neuron to another, but also…

Subcellular Processes · Quantitative Biology 2021-10-01 Sebastian Lotter , Arman Ahmadzadeh , Robert Schober

Neuropeptides, members of a large and evolutionarily ancient family of proteinaceous cell-cell signaling molecules, are widely recognized as extremely potent regulators of brain function and behavior. At the cellular level, neuropeptides…

Neurons and Cognition · Quantitative Biology 2020-04-20 Stephen J. Smith , Michael Hawrylycz , Jean Rossier , Uygar Sümbül

Artificial synapse is a key element of future brain-inspired neuromorphic computing systems implemented in hardware. This work presents a graphene synaptic transistor based on all-technology-compatible materials that exhibits highly tunable…

The extant versions of many basal ganglia models use a `gating' model of dopamine function which enhances input to D1 receptor units and attenuates input to D2 receptor units. There is evidence that this model is unsatisfactory because (a)…

Neurons and Cognition · Quantitative Biology 2007-05-23 M. D. Humphries

Strongly coupled, recurrent, balanced network models have been successful in describing and predicting many phenomena observed in cortical neural recordings. However, most balanced network models use current-based synapse models in place of…

Neurons and Cognition · Quantitative Biology 2026-05-13 Vicky Zhu , Gabriel Ocker , Robert Rosenbaum

The adaptive changes in synaptic efficacy that occur between spiking neurons have been demonstrated to play a critical role in learning for biological neural networks. Despite this source of inspiration, many learning focused applications…

Neural and Evolutionary Computing · Computer Science 2022-05-30 Samuel Schmidgall , Julia Ashkanazy , Wallace Lawson , Joe Hays

Synaptic plasticity is vital for learning and memory in the brain. It consists of long-term potentiation (LTP) and long-term depression (LTD). Spike frequency is one of the major components of synaptic plasticity in the brain, a noisy…

Neurons and Cognition · Quantitative Biology 2021-08-13 Yuto Takeda , Katsuhiko Hata , Tokio Yamasaki , Masaki Kaneko , Osamu Yokoi , Chengta Tsai , Kazuo Umemura , Tetsuro Nikuni

Neurons in a micro-circuit connected by chemical synapses can have their connectivity affected by the prior activity of the cells. The number of synapses available for releasing neurotransmitter can be decreased by repetitive activation…

Neurons and Cognition · Quantitative Biology 2018-04-09 Elham Bayat Mokhtari , J. Josh Lawrence , Emily F Stone

In the cerebral cortex, neurons are subject to a continuous bombardment of synaptic inputs originating from the network's background activity. This leads to ongoing, mostly subthreshold membrane dynamics that depends on the statistics of…

Biological Physics · Physics 2009-11-07 Ulrich Hillenbrand

We introduce Spike Agreement Dependent Plasticity (SADP), a biologically inspired synaptic learning rule for Spiking Neural Networks (SNNs) that relies on the agreement between pre- and post-synaptic spike trains rather than precise…

Neural and Evolutionary Computing · Computer Science 2025-08-25 Saptarshi Bej , Muhammed Sahad E , Gouri Lakshmi , Harshit Kumar , Pritam Kar , Bikas C Das

Spiking Neural Networks (SNNs) are more biologically plausible and computationally efficient. Therefore, SNNs have the natural advantage of drawing the sparse structural plasticity of brain development to alleviate the energy problems of…

Neural and Evolutionary Computing · Computer Science 2023-02-06 Bing Han , Feifei Zhao , Yi Zeng , Wenxuan Pan

We consider a fully-connected network of leaky integrate-and-fire neurons with spike-timing-dependent plasticity. The plasticity is controlled by a parameter representing the expected weight of a synapse between neurons that are firing…

Neurons and Cognition · Quantitative Biology 2011-09-23 Chun-Chung Chen , David Jasnow

As an emerging network model, spiking neural networks (SNNs) have aroused significant research attentions in recent years. However, the energy-efficient binary spikes do not augur well with gradient descent-based training approaches.…

Machine Learning · Computer Science 2023-04-27 Siqi Wang , Tee Hiang Cheng , Meng-Hiot Lim

Memristors have been widely studied as artificial synapses in neuromorphic circuits, due to their functional similarity with biological synapses, low operating power, and high integration density. In this work, a memristive synapse,…

Emerging Technologies · Computer Science 2023-08-29 Y. Liu , D. Wang , Z. Dong , H. Xie , W. Zhao

In neuroscience, synaptic plasticity refers to the set of mechanisms driving the dynamics of neuronal connections, called synapses and represented by a scalar value, the synaptic weight. A Spike-Timing Dependent Plasticity (STDP) rule is a…

Probability · Mathematics 2021-11-17 Philippe Robert , Gaetan Vignoud

Synaptic communication is a natural Molecular Communication (MC) system which may serve as a blueprint for the design of synthetic MC systems. In particular, it features highly specialized mechanisms to enable inter-symbol interference…

Emerging Technologies · Computer Science 2021-10-01 Sebastian Lotter , Maximilian Schäfer , Johannes Zeitler , Robert Schober

We investigate spike-timing dependent plasticity (STPD) in the case of a synapse connecting two neural cells. We develop a theoretical analysis of several STDP rules using Markovian theory. In this context there are two different…

Neurons and Cognition · Quantitative Biology 2021-11-16 Philippe Robert , Gaëtan Vignoud

The spiking activity of neocortical neurons exhibits a striking level of variability, even when these networks are driven by identical stimuli. The approximately Poisson firing of neurons has led to the hypothesis that these neural networks…

Neurons and Cognition · Quantitative Biology 2023-12-29 Logan A. Becker , Baowang Li , Nicholas J. Priebe , Eyal Seidemann , Thibaud Taillefumier

We study coherent multiple Andreev reflections in quantum SNS junctions of finite length and arbitrary transparency. The presence of superconducting bound states in these junctions gives rise to great enhancement of the subgap current. The…

Superconductivity · Physics 2007-05-23 Å. Ingerman , G. Johansson , V. S. Shumeiko , G. Wendin

Neuromorphic computing has emerged as a promising avenue towards building the next generation of intelligent computing systems. It has been proposed that memristive devices, which exhibit history-dependent conductivity modulation, could…