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Network alignment aims to find regions of topological or functional similarities between networks. In computational biology, it can be used to transfer biological knowledge from a well-studied species to a poorly-studied species between…

Molecular Networks · Quantitative Biology 2014-10-21 Joseph Crawford , Tijana Milenković

Phylogenetic networks are generalizations of trees that allow for the modeling of non-tree like evolutionary processes. Split networks give a useful way to construct networks with intuitive distance structures induced from the associated…

Combinatorics · Mathematics 2024-09-18 Bryson Kagy , Seth Sullivant

The study of the topological structure of complex networks has fascinated researchers for several decades, and today we have a fairly good understanding of the types and reoccurring characteristics of many different complex networks.…

Social and Information Networks · Computer Science 2014-06-23 Matthieu Roy , Stefan Schmid , Gilles Trédan

This article introduces a new class of models for multiple networks. The core idea is to parametrize a distribution on labelled graphs in terms of a Fr\'{e}chet mean graph (which depends on a user-specified choice of metric or graph…

Methodology · Statistics 2020-03-09 Simón Lunagómez , Sofia C. Olhede , Patrick J. Wolfe

Phylogenetic networks are used to study evolutionary relationships between species in biology. Such networks are often categorized into classes by their topological features, which stem from both biological and computational motivations. We…

Combinatorics · Mathematics 2020-04-17 Leo van Iersel , Remie Janssen , Mark Jones , Yukihiro Murakami , Norbert Zeh

We present the first sub-quadratic time algorithm that with high probability correctly reconstructs phylogenetic trees for short sequences generated by a Markov model of evolution. Due to rapid expansion in sequence databases, such very…

Populations and Evolution · Quantitative Biology 2012-06-01 Daniel G. Brown , Jakub Truszkowski

Graph neural networks (GNNs) have been applied to a large variety of applications in materials science and chemistry. Here, we recapitulate the graph construction for crystalline (periodic) materials and investigate its impact on the GNNs…

Machine Learning · Computer Science 2023-08-10 Robin Ruff , Patrick Reiser , Jan Stühmer , Pascal Friederich

Phylogenetic networks are a special type of graph which generalize phylogenetic trees and that are used to model non-treelike evolutionary processes such as recombination and hybridization. In this paper, we consider {\em unrooted}…

Combinatorics · Mathematics 2025-05-21 Katharina T. Huber , Simone Linz , Vincent Moulton

Phylogenetic networks provide a way to describe and visualize evolutionary histories that have undergone so-called reticulate evolutionary events such as recombination, hybridization or horizontal gene transfer. The level k of a network…

Populations and Evolution · Quantitative Biology 2008-07-21 Leo van Iersel , Steven Kelk , Matthias Mnich

Real-world events exhibit a high degree of interdependence and connections, and hence data points generated also inherit the linkages. However, the majority of AI/ML techniques leave out the linkages among data points. The recent surge of…

Social and Information Networks · Computer Science 2020-06-17 Shrey Dabhi , Manojkumar Parmar

Network reconstruction consists in retrieving the hidden interaction structure of a system from observations. Many reconstruction algorithms have been proposed, although less research has been devoted to describe their theoretical…

Biased (degree-dependent) percolation was recently shown to provide new strategies for turning robust networks fragile and vice versa. Here we present more detailed results for biased edge percolation on scale-free networks. We assume a…

Research shows that gene duplication followed by either repurposing or removal of duplicated genes is an important contributor to evolution of gene and protein interaction networks. We aim to identify which characteristics of a network can…

Molecular Networks · Quantitative Biology 2021-07-27 Peter Crawford-Kahrl , Robert R. Nerem , Bree Cummins , Tomas Gedeon

Phylogenetic networks are generalizations of phylogenetic trees that allow the representation of reticulation events such as horizontal gene transfer or hybridization, and can also represent uncertainty in inference. A subclass of these,…

Populations and Evolution · Quantitative Biology 2019-10-15 Mareike Fischer , Andrew Francis

Estimating the probabilities of linkages in a network has gained increasing interest in recent years. One popular model for network analysis is the exchangeable graph model (ExGM) characterized by a two-dimensional function known as a…

Methodology · Statistics 2018-09-05 Yi Su , Raymond K. W. Wong , Thomas C. M. Lee

A directed phylogenetic network is tree-child if every non-leaf vertex has a child that is not a reticulation. As a class of directed phylogenetic networks, tree-child networks are very useful from a computational perspective. For example,…

Combinatorics · Mathematics 2026-03-10 Leo van Iersel , Mark Jones , Simone Linz , Norbert Zeh

Many models of genome rearrangement involve operations (e.g. inversions and translocations) that are self-inverse, and hence generate a group acting on the space of genomes. This gives a correspondence between genome arrangements and the…

Group Theory · Mathematics 2016-01-19 Chad Clark , Attila Egri-Nagy , Andrew R. Francis , Volker Gebhardt

Phylogenetic networks describe the evolution of a set of taxa for which reticulate events have occurred at some point in their evolutionary history. Of particular interest is when the evolutionary history between a set of just three taxa…

Populations and Evolution · Quantitative Biology 2024-09-27 Shelby Cox , Elizabeth Gross , Samuel Martin

Polyploidization is an evolutionary process by which a species acquires multiple copies of its complete set of chromosomes. The reticulate nature of the signal left behind by it means that phylogenetic networks offer themselves as a…

Populations and Evolution · Quantitative Biology 2023-02-21 Katharina T. Huber , Liam J. Maher

Classification of gene trees is an important task both in the analysis of multi-locus phylogenetic data, and assessment of the convergence of Markov Chain Monte Carlo (MCMC) analyses used in Bayesian phylogenetic tree reconstruction. The…

Combinatorics · Mathematics 2024-06-10 Georgios Aliatimis , Ruriko Yoshida , Burak Boyaci , James A. Grant