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Gene regulation is a dynamic process that underlies all aspects of human development, disease response, and other key biological processes. The reconstruction of temporal gene regulatory networks has conventionally relied on regression…

Quantitative Methods · Quantitative Biology 2024-10-04 Euxhen Hasanaj , Barnabás Póczos , Ziv Bar-Joseph

Rooted phylogenetic networks are used by biologists to infer and represent complex evolutionary relationships between species that cannot be accurately explained by a phylogenetic tree. Tree-child networks are a particular class of rooted…

Combinatorics · Mathematics 2024-09-02 Janosch Döcker , Simone Linz

Hybridization networks are representations of evolutionary histories that allow for the inclusion of reticulate events like recombinations, hybridizations, or lateral gene transfers. The recent growth in the number of hybridization network…

Populations and Evolution · Quantitative Biology 2008-07-06 Gabriel Cardona , Merce Llabres , Francesc Rossello , Gabriel Valiente

Phylogenetic networks can represent evolutionary events that cannot be described by phylogenetic trees. These networks are able to incorporate reticulate evolutionary events such as hybridization, introgression, and lateral gene transfer.…

Populations and Evolution · Quantitative Biology 2021-07-08 Elizabeth Gross , Leo van Iersel , Remie Janssen , Mark Jones , Colby Long , Yukihiro Murakami

Evolutionary histories for species that cross with one another or exchange genetic material can be represented by leaf-labelled, directed graphs called phylogenetic networks. A major challenge in the burgeoning area of phylogenetic networks…

Data Structures and Algorithms · Computer Science 2021-09-24 Leo van Iersel , Sjors Kole , Vincent Moulton , Leonie Nipius

Normal networks are an important class of phylogenetic networks that have compelling mathematical properties which align with intuition about inference from genetic data. While tools enabling widespread use of phylogenetic networks in the…

Combinatorics · Mathematics 2025-12-16 Andrew Francis , Charles Semple

In evolutionary biology, networks are becoming increasingly used to represent evolutionary histories for species that have undergone non-treelike or reticulate evolution. Such networks are essentially directed acyclic graphs with a leaf set…

Populations and Evolution · Quantitative Biology 2023-08-23 Katharina T. Huber , Leo van Iersel , Vincent Moulton , Guillaume Scholz

We study random graph models for directed acyclic graphs, an important class of networks that includes citation networks, food webs, and feed-forward neural networks among others. We propose two specific models, roughly analogous to the…

Physics and Society · Physics 2009-10-16 Brian Karrer , M. E. J. Newman

In phylogenetics, reconstructing rooted trees from distances between taxa is a common task. B\"ocker and Dress generalized this concept by introducing symbolic dated maps $\delta:X \times X \to \Upsilon$, where distances are replaced by…

Combinatorics · Mathematics 2024-06-28 Anna Lindeberg , Guillaume E. Scholz , Marc Hellmuth

In phylogenetic networks, it is desirable to estimate edge lengths in substitutions per site or calendar time. Yet, there is a lack of scalable methods that provide such estimates. Here we consider the problem of obtaining edge length…

Populations and Evolution · Quantitative Biology 2024-08-06 Jingcheng Xu , Cécile Ané

We introduce a biologically natural, mathematically tractable model of random phylogenetic network to describe evolution in the presence of hybridization. One of the features of this model is that the hybridization rate of the lineages…

Probability · Mathematics 2024-02-27 François Bienvenu , Jean-Jil Duchamps

Complex networks have acquired a great popularity in recent years, since the graph representation of many natural, social and technological systems is often very helpful to characterize and model their phenomenology. Additionally, the…

Physics and Society · Physics 2009-02-06 Filippo Radicchi , Alain Barrat , Santo Fortunato , Jose J. Ramasco

We demonstrate the use of computational phylogenetic techniques to solve a central problem in inferential network monitoring. More precisely, we design a novel algorithm for multicast-based delay inference, i.e. the problem of…

Probability · Mathematics 2011-09-07 Shankar Bhamidi , Ram Rajagopal , Sebastien Roch

An important and well-studied problem in phylogenetics is to compute a \emph{consensus tree} so as to summarize the common features within a collection of rooted phylogenetic trees, all whose leaf-sets are bijectively labeled by the same…

Populations and Evolution · Quantitative Biology 2021-07-22 Katharina T. Huber , Vincent Moulton , Andreas Spillner

Networks are fundamental to the study of complex systems, ranging from social contacts, message transactions, to biological regulations and economical networks. In many realistic applications, these networks may vary over time. Modeling and…

Social and Information Networks · Computer Science 2020-04-07 Kun Tu , Jian Li , Don Towsley , Dave Braines , Liam Turner

We describe Galois connections which arise between two kinds of combinatorial structures, both of which generalize trees with labelled leaves, and then apply those connections to a family of polytopes. The graphs we study can be imbued with…

Combinatorics · Mathematics 2020-07-27 Stefan Forcey , Drew Scalzo

Phylogenetic networks are graphs that are used to represent evolutionary relationships between different taxa. They generalize phylogenetic trees since for example, unlike trees, they permit lineages to combine. Recently, there has been…

Populations and Evolution · Quantitative Biology 2025-08-05 Katharina T. Huber , Leo van Iersel , Mark Jones , Vincent Moulton , Leonie Veenema - Nipius

Predicting horizontal gene transfers often requires comparative sequence data, but recent work has shown that character-based approaches could also be useful for this task. Notably, perfect transfer networks (PTN) explain the character…

Discrete Mathematics · Computer Science 2025-06-17 Alitzel López Sánchez , Manuel Lafond

In mathematical phylogenetics, the time-consistent galled trees provide a simple class of rooted binary network structures that can be used to represent a variety of different biological phenomena. We study the enumerative combinatorics of…

Combinatorics · Mathematics 2025-04-24 Lily Agranat-Tamir , Michael Fuchs , Bernhard Gittenberger , Noah A. Rosenberg

The geometric renormalization technique for complex networks has successfully revealed the multiscale self-similarity of real network topologies and can be applied to generate replicas at different length scales. In this letter, we extend…

Physics and Society · Physics 2023-07-04 Muhua Zheng , Guillermo García-Pérez , Marián Boguñá , M. Ángeles Serrano
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