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The brain continually reorganizes its functional network to adapt to post-stroke functional impairments. Previous studies using static modularity analysis have presented global-level behavior patterns of this network reorganization.…

Computation · Statistics 2024-03-25 Kaichao Wu , Beth Jelfs , Katrina Neville , Wenzhen He , Qiang Fang

This paper describes an approach of using dynamic Structural Equation Modeling (SEM) analysis to estimate the connectivity networks from resting-state fMRI data measured by a multiband EPI sequence. Two structural equation models were…

Neurons and Cognition · Quantitative Biology 2017-04-03 Jiancheng Zhuang

Functional connections in the brain are frequently represented by weighted networks, with nodes representing locations in the brain, and edges representing the strength of connectivity between these locations. One challenge in analyzing…

Applications · Statistics 2022-09-28 Yura Kim , Daniel Kessler , Elizaveta Levina

Functional connectivity, as estimated using resting state fMRI, has shown potential in bridging the gap between pathophysiology and cognition. However, clinical use of functional connectivity biomarkers is impeded by unreliable estimates of…

Resting-state fMRI (rs-fMRI) functional connectivity (FC) analysis provides valuable insights into the relationships between different brain regions and their potential implications for neurological or psychiatric disorders. However,…

Image and Video Processing · Electrical Eng. & Systems 2023-11-20 Xiatian Zhang , Sisi Zheng , Hubert P. H. Shum , Haozheng Zhang , Nan Song , Mingkang Song , Hongxiao Jia

Correlation matrices are widely used to analyze the interdependence of variables in various real-world scenarios. Often, a perturbation in a few variables leads to mild differences in many correlation coefficients associated with these…

Applications · Statistics 2023-03-07 Itamar Faran , Michael Peer , Shahar Arzy , Yuval Benjamini

Resting-state functional magnetic resonance imaging (rs-fMRI), which measures the spontaneous fluctuations in the blood oxygen level-dependent (BOLD) signal, is increasingly utilized for the investigation of the brain's physiological and…

Traditional causal connectivity methods in task-based and resting-state functional magnetic resonance imaging (fMRI) face challenges in accurately capturing directed information flow due to their sensitivity to noise and inability to model…

Neurons and Cognition · Quantitative Biology 2025-04-03 Boseong Kim , Debashis Das Chakladar , Haejun Chung , Ikbeom Jang

Understanding the evolution of brain functional networks over time is of great significance for the analysis of cognitive mechanisms and the diagnosis of neurological diseases. Existing methods often have difficulty in capturing the…

Machine Learning · Computer Science 2025-10-30 Tianqi Guo , Liping Chen , Ciyuan Peng , Jingjing Zhou , Jing Ren

Measuring transient functional connectivity is an important challenge in Electroencephalogram (EEG) research. Here, the rich potential for insightful, discriminative information of brain activity offered by high temporal resolution is…

Neurons and Cognition · Quantitative Biology 2025-02-11 Om Roy , Yashar Moshfeghi , Agustin Ibanez , Francisco Lopera , Mario A Parra , Keith M Smith

Functional magnetic resonance imaging (fMRI) is widely used in clinical applications to highlight brain areas involved in specific cognitive processes. Brain impairments, such as tumors, suppress the fMRI activation of the anatomical areas…

Neurons and Cognition · Quantitative Biology 2019-06-20 Qiongge Li , Gino Del Ferraro , Luca Pasquini , Kyung K. Peck , Hernan A. Makse , Andrei I. Holodny

The contribution of structural connectivity to functional brain states remains poorly understood. We present a mathematical and computational study suited to assess the structure--function issue, treating a system of Jansen--Rit neural-mass…

Neurons and Cognition · Quantitative Biology 2020-07-10 Michael Forrester , Stephen Coombes , Jonathan J. Crofts , Stamatios N. Sotiropoulos , Reuben D. O'Dea

Functional neuroimaging can measure the brain?s response to an external stimulus. It is used to perform brain mapping: identifying from these observations the brain regions involved. This problem can be cast into a linear supervised…

Machine Learning · Computer Science 2012-07-03 Gael Varoquaux , Alexandre Gramfort , Bertrand Thirion

Network analysis is rapidly becoming a standard tool for studying functional magnetic resonance imaging (fMRI) data. In this framework, different brain areas are mapped to the nodes of a network, whose links depict functional dependencies…

Neurons and Cognition · Quantitative Biology 2017-05-30 Rainer Kujala , Enrico Glerean , Raj Kumar Pan , Iiro P. Jääskeläinen , Mikko Sams , Jari Saramäki

Accurate diagnosis of psychiatric disorders plays a critical role in improving the quality of life for patients and potentially supports the development of new treatments. Many studies have been conducted on machine learning techniques that…

Machine Learning · Statistics 2019-04-15 Takashi Matsubara , Tetsuo Tashiro , Kuniaki Uehara

The human connectome at the level of fiber tracts between brain regions has been shown to differ in patients with brain disorders compared to healthy control groups. Nonetheless, there is a potentially large number of different network…

Neurons and Cognition · Quantitative Biology 2013-10-16 Marcus Kaiser

Identifying brain regions that exhibit altered functional connectivity across cognitive or emotional states is a key problem in neuroscience. Existing methods, such as edge-wise testing, seed-based psychophysiological interaction (PPI)…

Methodology · Statistics 2026-02-12 Shira Yoffe , Ziv Ben-Zion , Guy Gurevitch , Talma Hendler , Malka Gorfine , Ariel Jaffe

We present a computational framework for analysis and visualization of non-linear functional connectivity in the human brain from resting state functional MRI (fMRI) data for purposes of recovering the underlying network community structure…

Neural and Evolutionary Computing · Computer Science 2014-07-16 Axel Wismüller , Xixi Wang , Adora M. DSouza , Mahesh B. Nagarajan

With our ability to record more neurons simultaneously, making sense of these data is a challenge. Functional connectivity is one popular way to study the relationship between multiple neural signals. Correlation-based methods are a set of…

Neurons and Cognition · Quantitative Biology 2017-06-09 Tiger W. Lin , Anup Das , Giri P. Krishnan , Maxim Bazhenov , Terrence J. Sejnowski

Functional connectivity plays an essential role in modern neuroscience. The modality sheds light on the brain's functional and structural aspects, including mechanisms behind multiple pathologies. One such pathology is schizophrenia which…

Neurons and Cognition · Quantitative Biology 2022-06-07 Maksim Zhdanov , Saskia Steinmann , Nico Hoffmann