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Complementary DNA strands in solution reliably hybridize to form stable duplexes. We study the kinetics of the hybridization process and the mechanisms by which two initially isolated strands come together to form a stable double helix. We…

Biological Physics · Physics 2019-03-27 Raymond Jin , Lutz Maibaum

Below the melting temperature $T_m$ crystals are the stable phase of typical elemental or molecular systems. However, cooling down a liquid below $T_m$, crystallization is anything but inevitable. The liquid can be supercooled, eventually…

Disordered Systems and Neural Networks · Physics 2017-03-07 M. Zanatta , L. Cormier , L. Hennet , C. Petrillo , F. Sacchetti

Self-assembly is traditionally described as the process through which an initially disordered system relaxes towards an equilibrium ordered phase only driven by local interactions between its building blocks. However, This definition is too…

Soft Condensed Matter · Physics 2015-06-15 Lorenzo Di Michele , Francesco Varrato , Jurij Kotar , Simon H. Nathan , Giuseppe Foffi , Erika Eiser

There are large number of proteins, the existence of which are known but not their crystal structure, because of difficulty in finding the exact condition for their crystallization. Heterogeneous nucleation on disordered porous substrates…

Biological Physics · Physics 2015-10-19 Anindita Sengupta Ghatak , Animangsu Ghatak

The mechanical separation of the double helical DNA structure induced by forces pulling apart the two DNA strands (``unzipping'') has been the subject of recent experiments. Analytical results are obtained within various models of…

Statistical Mechanics · Physics 2009-11-07 D. Marenduzzo , A. Trovato , A. Maritan

The dynamics of the DNA denaturation is studied using the Peyrard-Bishop-Dauxois model. The denaturation rate of double stranded polymers decreases exponentially as function of length below the denaturation temperature. Above Tc, the rate…

Biological Physics · Physics 2015-06-04 Titus S. van Erp , Michel Peyrard

We present an extensive theoretical investigation of the mechanical unzipping of double-stranded DNA under the influence of an applied force. In the limit of long polymers, there is a thermodynamic unzipping transition at a critical force…

Soft Condensed Matter · Physics 2009-11-07 David K. Lubensky , David R. Nelson

Single molecule studies, at constant force, of the separation of double-stranded DNA into two separated single strands may provide information relevant to the dynamics of DNA replication. At constant applied force, theory predicts that the…

We predict a novel temperature-driven phase transition of DNA below the melting transition. The additional, intermediate phase exists for repetitive sequences, when the two strands have different lengths. In this phase, the excess bases of…

Biomolecules · Quantitative Biology 2007-05-23 Richard A. Neher , Ulrich Gerland

The statistical physics of homogeneous DNA is investigated by the imaginary time path integral formalism. The base pair stretchings are described by an ensemble of paths selected through a macroscopic constraint, the fulfillement of the…

Statistical Mechanics · Physics 2009-04-30 Marco Zoli

We report studies of the equilibrium and the dynamics of a general set of lattice models which capture the essence of the force-induced or mechanical DNA unzipping transition. Besides yielding the whole equilibrium phase diagram in the…

Soft Condensed Matter · Physics 2009-11-07 D. Marenduzzo , S. M. Bhattacharjee , A. Maritan , E. Orlandini , F. Seno

Wigner crystallization of electrons in a 2D quantum dots is reported. It proceeds in two stages: I) via radial ordering of electrons on shells and II) freezing of the inter-shell rotation. The phase boundary of the crystal is computed in…

Mesoscale and Nanoscale Physics · Physics 2009-10-31 A. V. Filinov , M. Bonitz , Yu. E. Lozovik

The formation of bubbles in nucleic acids (NAs) are fundamental in many biological processes such as DNA replication, recombination, telomeres formation, nucleotide excision repair, as well as RNA transcription and splicing. These precesses…

Biomolecules · Quantitative Biology 2007-05-23 D. Hennig , J. F. R. Archilla , J. M. Romero

We study the evolution from a liquid to a crystal phase in two-dimensional curved space. At early times, while crystal seeds grow preferentially in regions of low curvature, the lattice frustration produced in regions with high curvature is…

Soft Condensed Matter · Physics 2015-06-16 Nicolas A. Garcia , Richard A. Register , Daniel A. Vega , Leopoldo R. Gomez

We examine the interactions between actively rotating proteins moving in a membrane. Experimental evidence suggests that such rotor proteins, like the ATP synthases of the inner mitochondrial membrane, can arrange themselves into lattices.…

Soft Condensed Matter · Physics 2019-10-09 Naomi Oppenheimer , David B. Stein , Michael J. Shelley

To characterize the thermodynamical equilibrium of DNA chains interacting with a solution of non-specific binding proteins, a Flory-Huggins free energy model was implemented. We explored the dependence on DNA and protein concentrations of…

Soft Condensed Matter · Physics 2015-11-04 Guillaume Le Treut , François Képès , Henri Orland

The structural evolution of suspensions upon freezing is studied with optical microscopy in a suspended droplet configuration. Droplets have millimeter size and consist in an aqueous mixture of silica particles while the surroundings phase…

Soft Condensed Matter · Physics 2018-05-10 Mathieu Nespoulous , Renaud Denoyel , Mickaël Antoni

We have carried out computer simulations of overcompressed suspensions of hard monodisperse ellipsoids and observed their crystallization dynamics. The system was compressed very rapidly in order to reach the regime of slow, glass-like…

Soft Condensed Matter · Physics 2013-10-01 Sven Dorosz , Tanja Schilling

The opening of the Y-fork - the first step of DNA replication - is shown to be a critical phenomenon under an external force at one of its ends. From the results of an equivalent delocalization in a non-hermitian quantum-mechanics problem…

Statistical Mechanics · Physics 2009-10-31 Somendra M. Bhattacharjee

We show that a long DNA molecule can form a novel condensed phase of matter, the pseudoscalar liquid crystal, that consists of aperiodically ordered DNA fragments in right-handed B and left-handed Z forms. We discuss the possibility of…

Soft Condensed Matter · Physics 2009-05-14 K. G. Petrosyan , Chin-Kun Hu