Related papers: A population-based microbial oscillator
Driven by advancements in high-throughput biological technologies and the growing number of sequenced genomes, the construction of in silico models at the genome scale has provided powerful tools to investigate a vast array of biological…
Computing with synthetically engineered bacteria is a vibrant and active field with numerous applications in bio-production, bio-sensing, and medicine. Motivated by the lack of robustness and by resource limitation inside single cells,…
Synchronization of mobile oscillators occurs in numerous contexts, including physical, chemical, biological and engineered systems. In vertebrate embryonic development, a segmental body structure is generated by a population of mobile…
Rapidly assaying the diversity of a bacterial species present in a sample obtained from a hospital patient or an evironmental source has become possible after recent technological advances in DNA sequencing. For several applications it is…
Oscillatory gene circuits are ubiquitous to biology and are involved in fundamental processes of cell cycle, circadian rhythms and developmental systems. The synthesis of small, non-natural oscillatory genetic circuits have been…
Recently, self-sustained oscillations in complex networks consisting of nonoscillatory nodes (network oscillators) have attracted great interest in diverse natural and social fields. Due to complexity of network behaviors, little is known…
We present a proof-of-concept of a model comparison approach for analyzing spatio-temporal observations of interacting populations. Our model variants are a collection of structurally similar Bayesian networks. Their distinct Noisy-Or…
Using a population dynamics inspired by an ensemble of growing cells, a set of fluctuation theorems linking observables measured at the lineage and population levels are derived. One of these relations implies specific inequalities…
We study a way to set the natural frequency of a newly added oscillator in a growing network to enhance synchronization. Population growth is one of the typical features of many oscillator systems for which synchronization is required to…
Unicellular organisms exhibit elaborate collective behaviors in response to environmental cues. These behaviors are controlled by complex biochemical networks within individual cells and coordinated through cell-to-cell communication.…
Oscillators coupled in a network can synchronize with each other to yield a coherent population rhythm. If multiple such networks are coupled together, the question arises whether these rhythms will synchronize. We investigate the impact of…
Computer simulations have become an important tool across the biomedical sciences and beyond. For many important problems several different models or hypotheses exist and choosing which one best describes reality or observed data is not…
Synchronization is known to play a vital role within many highly connected neural systems such as the olfactory systems of fish and insects. In this paper we show how one can robustly and effectively perform practical computations using…
The study on the collective dynamics of synchronization among genetic oscillators is essential for the understanding of the rhythmic phenomena of living organisms at both molecular and cellular levels. Genetic oscillators are biochemical…
Based on a multi-agent model, we investigate how target waves emerge from a population dynamics with cyclical interactions among three species. We show that the periodically injecting source in a small central area can generate target waves…
We study molecular dynamics within populations of diffusively coupled cells under the assumption of fast diffusive exchange. As a technical tool, we propose conditions on boundedness and ultimate boundedness for systems with a singular…
Dynamical systems on networks with adaptive couplings appear naturally in real-world systems such as power grid networks, social networks as well as neuronal networks. We investigate a paradigmatic system of adaptively coupled phase…
The emergence of multicellularity and developmental programs are among the major problems of evolutionary biology. Traditionally, research in this area has been based on the combination of data analysis and experimental work on one hand and…
We fabricate a microscale electromechanical system, in which a suspended superconducting membrane, treated as a mechanical oscillator, capacitively couples to a superconducting microwave resonator. As the microwave driving power increases,…
The increasing difficulty in continued development of digital electronic logic has led to a renewed interest in alternative approaches. Oscillatory computing is one such approach that leverages alternative physical systems and computation…