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The mutational heterogeneity of tumours can be described with a tree representing the evolutionary history of the tumour. With noisy sequencing data there may be uncertainty in the inferred tree structure, while we may also wish to study…

Computational Complexity · Computer Science 2025-01-14 Luís Cunha , Jack Kuipers , Thiago Lopes

Accurate reconstruction of phylogenies remains a key challenge in evolutionary biology. Most biologically plausible formulations of the problem are formally NP-hard, with no known efficient solution. The standard in practice are fast…

Populations and Evolution · Quantitative Biology 2015-05-14 Navodit Misra , Guy Blelloch , R. Ravi , Russell Schwartz

We study the Gaussian statistical models whose log-likelihood function has a unique complex critical point, i.e., has maximum likelihood degree one. We exploit the connection developed by Am\'endola et. al. between the models having maximum…

Algebraic Geometry · Mathematics 2024-12-04 Shelby Cox , Pratik Misra , Pardis Semnani

Estimating phylogenetic trees is an important problem in evolutionary biology, environmental policy and medicine. Although trees are estimated, their uncertainties are discarded by mathematicians working in tree space. Here we explicitly…

Methodology · Statistics 2017-10-16 Amy D. Willis , Rayna C. Bell

Quartet Reconstruction, the task of recovering a phylogenetic tree from smaller trees on four species called \textit{quartets}, is a well-studied problem in theoretical computer science with far-reaching connections to statistics, graph…

Data Structures and Algorithms · Computer Science 2026-04-21 Dionysis Arvanitakis , Vaggos Chatziafratis , Yiyuan Luo , Konstantin Makarychev

Counting the number of spanning trees in specific classes of graphs has attracted increasing attention in recent years. In this note, we present unified proofs and generalizations of several results obtained in the 2020s. The main method is…

Combinatorics · Mathematics 2025-06-04 Danila Cherkashin , Pavel Prozorov

The reconstruction of phylogenetic networks is an important but challenging problem in phylogenetics and genome evolution, as the space of phylogenetic networks is vast and cannot be sampled well. One approach to the problem is to solve the…

Populations and Evolution · Quantitative Biology 2023-04-14 Louxin Zhang , Niloufar Abhari , Caroline Colijn , Yufeng Wu

Motivated by applications in genetic fields, we propose to estimate the heritability in high dimensional sparse linear mixed models. The heritability determines how the variance is shared between the different random components of a linear…

Statistics Theory · Mathematics 2015-05-07 Anna Bonnet , Elisabeth Gassiat , Céline Lévy-Leduc

This paper studies a Markov chain for phylogenetic reconstruction which uses a popular transition between tree topologies known as subtree pruning-and-regrafting (SPR). We analyze the Markov chain in the simpler setting that the generating…

Populations and Evolution · Quantitative Biology 2015-03-13 Daniel Stefankovic , Eric Vigoda

A classical problem in phylogenetic tree analysis is to decide whether there is a phylogenetic tree $T$ that contains all information of a given collection $\cP$ of phylogenetic trees. If the answer is "yes" we say that $\cP$ is compatible…

Combinatorics · Mathematics 2010-06-29 Stefan Grünewald

Inferring the ancestral state at the root of a phylogenetic tree from states observed at the leaves is a problem arising in evolutionary biology. The simplest technique -- majority rule -- estimates the root state by the most frequently…

Populations and Evolution · Quantitative Biology 2014-04-11 Elchanan Mossel , Mike Steel

It is a known fact that, given two rooted binary phylogenetic trees, the concept of maximum acyclic agreement forests is sufficient to compute hybridization networks with minimum hybridization number. In this work, we demonstrate by first…

Populations and Evolution · Quantitative Biology 2015-12-18 Benjamin Albrecht

Estimating heritability remains a significant challenge in statistical genetics. Diverse approaches have emerged over the years that are broadly categorized as either random effects or fixed effects heritability methods. In this work, we…

Methodology · Statistics 2024-06-18 Yanke Song , Xihong Lin , Pragya Sur

Patterns on numerical semigroups are multivariate linear polynomials, and they are said to be admissible if there exists a numerical semigroup such that evaluated at any nonincreasing sequence of elements of the semigroup gives integers…

Number Theory · Mathematics 2012-11-06 Maria Bras-Amorós , Pedro A. García-Sánchez , Albert Vico-Oton

We study the complexity and expressive power of conjunctive queries over unranked labeled trees represented using a variety of structure relations such as ``child'', ``descendant'', and ``following'' as well as unary relations for node…

Databases · Computer Science 2007-05-23 Georg Gottlob , Christoph Koch , Klaus U. Schulz

We introduce new methods for phylogenetic tree quartet construction by using machine learning to optimize the power of phylogenetic invariants. Phylogenetic invariants are polynomials in the joint probabilities which vanish under a model of…

Populations and Evolution · Quantitative Biology 2007-05-23 Nicholas Eriksson , Yuan Yao

Estimating the phylogeny of the genus Homo is entering a new phase of vastly improved data and methodology. There is increasing evidence of 6 to 10 competing species/lineages at any point in the last half million years, making the…

Populations and Evolution · Quantitative Biology 2017-01-02 Peter J. Waddell

There exist several methods dealing with the reconstruction of rooted phylogenetic networks explaining different evolutionary histories given by rooted binary phylogenetic trees. In practice, however, due to insufficient information of the…

Populations and Evolution · Quantitative Biology 2015-12-18 Benjamin Albrecht

Let $T$ be an arbitrary phylogenetic tree with $n$ leaves. It is well-known that the average quartet distance between two assignments of taxa to the leaves of $T$ is $\frac 23 \binom{n}{4}$. However, a longstanding conjecture of Bandelt and…

Populations and Evolution · Quantitative Biology 2021-11-29 Sagi Snir , Osnat Weissberg , Raphael Yuster

We investigate a network growth model in which the genealogy controls the evolution. In this model, a new node selects a random target node and links either to this target node, or to its parent, or to its grandparent, etc; all nodes from…

Statistical Mechanics · Physics 2010-06-04 E. Ben-Naim , P. L. Krapivsky