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Circadian rhythmicity lies at the center of various important physiological and behavioral processes in mammals, such as sleep, metabolism, homeostasis, mood changes and more. It has been shown that this rhythm arises from self-sustained…

Neurons and Cognition · Quantitative Biology 2023-02-08 Yorgos M. Psarellis , Michail Kavousanakis , Michael A. Henson , Ioannis G. Kevrekidis

The suprachiasmatic nucleus (SCN), also known as the circadian master clock, consists of a large population of oscillator neurons. Together, these neurons produce a coherent signal that drives the body's circadian rhythms. What properties…

Neurons and Cognition · Quantitative Biology 2023-01-04 Stéphanie M. C. Abo , José A. Carrillo , Anita T. Layton

The synchronization of biological activity with the alternation of day and night (circadian rhythm) is performed in the brain by a group of neurons, constituting the suprachiasmatic nucleus (SCN). The SCN is divided into two subgroups of…

Adaptation and Self-Organizing Systems · Physics 2026-01-09 Jinshan Xu , Changgui Gu , Alain Pumir , Nicolas Garnier , Zonghua Liu

The coherence resonance (CR) of globally coupled Hodgkin-Huxley neurons is studied. When the neurons are set in the subthreshold regime near the firing threshold, the additive noise induces limit cycles. The coherence of the system is…

Biological Physics · Physics 2009-10-31 Yuqing Wang , David T. W. Chik , Z. D. Wang

Circadian clocks are biochemical oscillators that allow organisms to estimate the time of the day. These oscillators are inherently noisy due to the discrete nature of the reactants and the stochastic character of their interactions. To…

Biological Physics · Physics 2018-03-21 Michele Monti , David K. Lubensky , Pieter Rein ten Wolde

Autonomous circadian clocks drive daily rhythms in physiology and behaviour. A network of coupled neurons, the suprachiasmatic nucleus (SCN), serves as a robust self-sustained circadian pacemaker. Synchronization of this timer to the…

Adaptation and Self-Organizing Systems · Physics 2015-05-28 G. Bordyugov , A. E. Granada , H. Herzel

A biophysical model of arousal dynamics is used to study mechanisms of synchronisation and loss of synchrony among the three key oscillators controlling sleep-wake cycles: the circadian, homeostatic, and light oscillators. Synchronisation…

Biological Physics · Physics 2021-01-22 Dmitry E. Postnov , Ksenia O. Merkulova , Svetlana Postnova

Almost all organisms show some kind of time periodicity in their behavior. Especially in mammals the neurons of the suprachiasmatic nucleus form a biological clock regulating the activity-inactivity cycle of the animal. This clock is…

Adaptation and Self-Organizing Systems · Physics 2011-11-24 Domien G. M. Beersma , Henk W. Broer , Konstantinos Efstathiou , Kim A. Gargar , Igor Hoveijn

This article investigates the emergence of phase synchronization in a network of randomly connected neurons by chemical synapses. The study uses the classic Hodgkin-Huxley model to simulate the neuronal dynamics under the action of a train…

Daylight plays a major role in the wake/sleep cycle in humans. Indeed, the wake/sleep system stems from biological systems that follow a circadian rhythm determined by the light/dark alternation. The oscillations can be modeled by the…

Biological Physics · Physics 2022-01-13 F. L. Tsafack Tayong , R. Yamapi , G. Filatrella

Circadian rhythms are acquired through evolution to increase the chances for survival through synchronizing with the daylight cycle. Reliable synchronization is realized through two trade-off properties: regularity to keep time precisely,…

Biological Physics · Physics 2014-10-02 Yoshihiko Hasegawa , Masanori Arita

Synchronization phenomena are pervasive in biology. In neuronal networks, the mechanisms of synchronization have been extensively studied from both physiological and computational viewpoints. The functional role of synchronization has also…

Neurons and Cognition · Quantitative Biology 2009-06-18 Nicolas Tabareau , Jean-Jacques Slotine , Quang-Cuong Pham

The ability of a circadian system to entrain to the 24-hour light-dark cycle is one of its most important properties. A new tool, called the entrainment map, was recently introduced to study this process for a single oscillator. Here we…

Dynamical Systems · Mathematics 2020-04-17 Guangyuan Liao , Casey Diekman , Amitabha Bose

Synchronization is a widespread phenomenon observed in physical, biological, and social networks, which persists even under the influence of strong noise. Previous research on oscillators subject to common noise has shown that noise can…

Adaptation and Self-Organizing Systems · Physics 2021-06-02 Zachary G. Nicolaou , Michael Sebek , Istvan Z. Kiss , Adilson E. Motter

For many natural and engineered systems, a central function or design goal is the synchronization of one or more rhythmic or oscillating processes to an external forcing signal, which may be periodic on a different time-scale from the…

Dynamical Systems · Mathematics 2014-01-10 Anatoly Zlotnik , Jr-Shin Li

In mammals, most cells in the brain and peripheral tissues generate circadian (~24hr) rhythms autonomously. These self-sustained rhythms are coordinated and entrained by a master circadian clock in the suprachiasmatic nucleus (SCN). Within…

Molecular Networks · Quantitative Biology 2014-06-10 Jae Kyoung Kim , Zachary P. Kilpatrick , Matthew R. Bennett , Krešimir Josić

Synchronization dynamics is a phenomenon of great interest in many fields of science. One of the most important fields is neuron dynamics, as synchronization in certain regions of the brain is related to some of the most common mental…

Neurons and Cognition · Quantitative Biology 2025-04-09 J. Used , J. M. Seoane , I. Bashkirtseva , L. Ryashko , M. A. F. Sanjuán

We study the impact of light on the mammalian circadian system using the theory of phase response curves. Using a recently developed ansatz we derive a low-dimensional macroscopic model for the core circadian clock in mammals.…

Neurons and Cognition · Quantitative Biology 2019-10-14 Kevin M. Hannay , Daniel B. Forger , Victoria Booth

Rhythms in electrical activity in the membrane of cells in the suprachiasmatic nucleus (SCN) are crucial for the function of the circadian timing system, which is characterized by the expression of the so-called clock genes. Intracellular…

Biological Physics · Physics 2015-03-23 J. M. Casado , M. Morillo

The study of synchronization in biological systems is essential for the understanding of the rhythmic phenomena of living organisms at both molecular and cellular levels. In this paper, by using simple dynamical systems theory, we present a…

Molecular Networks · Quantitative Biology 2007-05-23 Chunguang Li , Luonan Chen , Kazuyuki Aihara
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