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Bayesian inference methods rely on numerical algorithms for both model selection and parameter inference. In general, these algorithms require a high computational effort to yield reliable estimates. One of the major challenges in…

Quantitative Methods · Quantitative Biology 2018-08-09 Patricio Maturana , Brendon J. Brewer , Steffen Klaere , Remco Bouckaert

Image-text matching is an interesting and fascinating task in modern AI research. Despite the evolution of deep-learning-based image and text processing systems, multi-modal matching remains a challenging problem. In this work, we consider…

Computer Vision and Pattern Recognition · Computer Science 2021-01-27 Nicola Messina , Fabrizio Falchi , Andrea Esuli , Giuseppe Amato

High-throughput sequencing (HTS) is revolutionizing biological research by enabling scientists to quickly and cheaply query variation at a genomic scale. Despite the increasing ease of obtaining such data, using these data effectively still…

Genomics · Quantitative Biology 2012-11-09 Sonal Singhal

Phylogenetic networks have gained prominence over the years due to their ability to represent complex non-treelike evolutionary events such as recombination or hybridization. Popular combinatorial objects used to construct them are triplet…

Combinatorics · Mathematics 2016-10-19 P. Gambette , K. T. Huber , S. Kelk

Robust tensor completion (RTC) aims to recover a low-rank tensor from its incomplete observation with outlier corruption. The recently proposed tensor ring (TR) model has demonstrated superiority in solving the RTC problem. However, the…

Machine Learning · Computer Science 2023-02-16 Zhenhao Huang , Yuning Qiu , Xinqi Chen , Weijun Sun , Guoxu Zhou

Multi-Task Learning (MTL) has shown its importance at user products for fast training, data efficiency, reduced overfitting etc. MTL achieves it by sharing the network parameters and training a network for multiple tasks simultaneously.…

Machine Learning · Computer Science 2022-12-08 Brijraj Singh , Swati Gupta , Mayukh Das , Praveen Doreswamy Naidu , Sharan Kumar Allur

Motif finding in DNA, RNA and proteins plays an important role in life science research. Recent patents concerning motif finding in the biomolecular data are recorded in the DNA Patent Database which serves as a resource for policy makers…

Computational Engineering, Finance, and Science · Computer Science 2017-01-03 Kevin Byron , Jason T. L. Wang

Motivation: Millions of genes in the modern species belong to only thousands of `gene families'. A gene family includes instances of the same gene in different species (orthologs) and duplicate genes in the same species (paralogs). Genes…

Populations and Evolution · Quantitative Biology 2012-05-04 Yu Zheng , Taoyang Wu , Louxin Zhang

Nested sampling (NS) computes parameter posterior distributions and makes Bayesian model comparison computationally feasible. Its strengths are the unsupervised navigation of complex, potentially multi-modal posteriors until a well-defined…

Computation · Statistics 2023-07-11 Johannes Buchner

Tanglegrams are a special class of graphs appearing in applications concerning cospeciation and coevolution in biology and computer science. They are formed by identifying the leaves of two rooted binary trees. We give an explicit formula…

Combinatorics · Mathematics 2015-07-20 Sara Billey , Matjaž Konvalinka , Frederick A Matsen

The general trace reconstruction problem seeks to recover an original sequence from its noisy copies independently corrupted by deletions, insertions, and substitutions. This problem arises in applications such as DNA data storage, a…

Machine Learning · Computer Science 2025-07-18 Franziska Weindel , Michael Girsch , Reinhard Heckel

RNA's diverse biological functions stem from its structural versatility, yet accurately predicting and designing RNA sequences given a 3D conformation (inverse folding) remains a challenge. Here, I introduce a deep learning framework that…

Quantitative Methods · Quantitative Biology 2026-01-06 Annabelle Yao

Circular RNAs (circRNAs) are important components of the non-coding RNA regulatory network. Previous circRNA identification primarily relies on high-throughput RNA sequencing (RNA-seq) data combined with alignment-based algorithms that…

Machine Learning · Computer Science 2025-07-14 Tianyou Jiang

We introduce a deep residual recurrent neural network (DR-RNN) as an efficient model reduction technique for nonlinear dynamical systems. The developed DR-RNN is inspired by the iterative steps of line search methods in finding the residual…

Computational Engineering, Finance, and Science · Computer Science 2017-09-05 J. Nagoor Kani , Ahmed H. Elsheikh

Computational protein design has the potential to deliver novel molecular structures, binders, and catalysts for myriad applications. Recent neural graph-based models that use backbone coordinate-derived features show exceptional…

Biomolecules · Quantitative Biology 2022-04-28 Alex J. Li , Vikram Sundar , Gevorg Grigoryan , Amy E. Keating

Standard ChIP-seq peak calling pipelines seek to differentiate biochemically reproducible signals of individual genomic elements from background noise. However, reproducibility alone does not imply functional regulation (e.g., enhancer…

Machine Learning · Statistics 2023-07-17 Karl Kumbier , Sumanta Basu , Erwin Frise , Susan E. Celniker , James B. Brown , Susan Celniker , Bin Yu

We present TripNet, a method for constructing phylogenetic networks from triplets. We will present the motivations behind our approach and its theoretical and empirical justification. To demonstrate the accuracy and efficiency of TripNet,…

Computational Engineering, Finance, and Science · Computer Science 2015-03-19 Ruzbeh Tusserkani , Changiz Eslahchi , Hadi Poormohammadi , Azin Azadi

The study of deep neural networks (DNNs) in the infinite-width limit, via the so-called neural tangent kernel (NTK) approach, has provided new insights into the dynamics of learning, generalization, and the impact of initialization. One key…

Machine Learning · Computer Science 2021-06-16 Sina Alemohammad , Zichao Wang , Randall Balestriero , Richard Baraniuk

We propose a new neural network framework, termed Neural Network Machine Regression (NNMR), which integrates trainable input gating and adaptive depth regularization to jointly perform feature selection and function estimation in an…

Methodology · Statistics 2026-02-03 Jiuchen Zhang , Ling Zhou , Peter Song

We present a new method to detect duplicates used to merge different bibliographic record corpora with the help of lexical and social information. As we show, a trivial key is not available to delete useless documents. Merging heteregeneous…

Databases · Computer Science 2015-04-29 Nicolas Turenne