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In the recent years, DNA has emerged as a potentially viable storage technology. DNA synthesis, which refers to the task of writing the data into DNA, is perhaps the most costly part of existing storage systems. Accordingly, this high cost…

Information Theory · Computer Science 2022-04-15 Ohad Elishco , Wasim Huleihel

Over the past years, the ever-growing trend on data storage demand, more specifically for "cold" data (rarely accessed data), has motivated research for alternative systems of data storage. Because of its biochemical characteristics,…

Image and Video Processing · Electrical Eng. & Systems 2023-06-23 Xavier Pic , Eva Gil San Antonio , Melpomeni Dimopoulou , Marc Antonini

Due to their sequential nature, traditional DNA synthesis methods are expensive in terms of time and resources. They also fabricate multiple copies of the same strand, introducing redundancy. This redundancy can be leveraged to enhance the…

Information Theory · Computer Science 2025-10-29 Frederik Walter , Yonatan Yehezkeally

In a distributed information application an encoder compresses an arbitrary vector while a similar reference vector is available to the decoder as side information. For the Hamming-distance similarity measure, and when guaranteed perfect…

Information Theory · Computer Science 2020-09-08 Yuval Cassuto , Jacob Ziv

In the current era, DeoxyriboNucleic Acid (DNA) based data storage emerges as an intriguing approach, garnering substantial academic interest and investigation. This paper introduces a novel deep joint source-channel coding (DJSCC) scheme…

Emerging Technologies · Computer Science 2023-11-03 Wenfeng Wu , Luping Xiang , Qiang Liu , Kun Yang

The yearly global production of data is growing exponentially, outpacing the capacity of existing storage media, such as tape and disk, and surpassing our ability to store it. DNA storage - the representation of arbitrary information as…

Quantitative Methods · Quantitative Biology 2023-10-04 Thomas Heinis , Roman Sokolovskii , Jamie J. Alnasir

Storing digital data in synthetic DNA faces challenges in ensuring data reliability in the presence of edit errors--deletions, insertions, and substitutions--that occur randomly during various stages of the storage process. Current…

Information Theory · Computer Science 2025-09-11 Serge Kas Hanna

We propose generative neural network methods to generate DNA sequences and tune them to have desired properties. We present three approaches: creating synthetic DNA sequences using a generative adversarial network; a DNA-based variant of…

Machine Learning · Computer Science 2017-12-19 Nathan Killoran , Leo J. Lee , Andrew Delong , David Duvenaud , Brendan J. Frey

We demonstrate how a genetic algorithm solves the problem of minimizing the resources used for network coding, subject to a throughput constraint, in a multicast scenario. A genetic algorithm avoids the computational complexity that makes…

Neural and Evolutionary Computing · Computer Science 2007-05-23 Minkyu Kim , Varun Aggarwal , Una-May O'Reilly , Muriel Medard , Wonsik Kim

Traditionally, data compression deals with the problem of concisely representing a data source, e.g. a sequence of letters, for the purpose of eventual reproduction (either exact or approximate). In this work we are interested in the case…

Information Theory · Computer Science 2013-12-10 Amir Ingber , Tsachy Weissman

We describe properties and constructions of constraint-based codes for DNA-based data storage which account for the maximum repetition length and AT/GC balance. We present algorithms for computing the number of sequences with maximum…

Information Theory · Computer Science 2018-12-18 Kees A. Schouhamer Immink , Kui Cai

The process of DNA-based data storage (DNA storage for short) can be mathematically modelled as a communication channel, termed DNA storage channel, whose inputs and outputs are sets of unordered sequences. To design error correcting codes…

Information Theory · Computer Science 2020-06-11 Wentu Song , Kui Cai , Kees A. Schouhamer Immink

Data compression has been widely applied in many data processing areas. Compression methods use variable-size codes with the shorter codes assigned to symbols or groups of symbols that appear in the data frequently. Fibonacci coding, as a…

Performance · Computer Science 2007-12-19 R. Baca , V. Snasel , J. Platos , M. Kratky , E. El-Qawasmeh

Recently, a series of algorithms have been explored for GAN compression, which aims to reduce tremendous computational overhead and memory usages when deploying GANs on resource-constrained edge devices. However, most of the existing GAN…

Computer Vision and Pattern Recognition · Computer Science 2021-11-10 Shaojie Li , Jie Wu , Xuefeng Xiao , Fei Chao , Xudong Mao , Rongrong Ji

This paper studies two problems that are motivated by the novel recent approach of composite DNA that takes advantage of the DNA synthesis property which generates a huge number of copies for every synthesized strand. Under this paradigm,…

Information Theory · Computer Science 2025-05-15 Tomer Cohen , Eitan Yaakobi

Genome data are crucial in modern medicine, offering significant potential for diagnosis and treatment. Thanks to technological advancements, many millions of healthy and diseased genomes have already been sequenced; however, obtaining the…

Genomics · Quantitative Biology 2024-06-18 Teddy Lazebnik , Liron Simon-Keren

In this paper, we study methods for improving the efficiency and privacy of compressed DNA sequence comparison computations, under various querying scenarios. For instance, one scenario involves a querier, Bob, who wants to test if his DNA…

Cryptography and Security · Computer Science 2011-07-20 David Eppstein , Michael T. Goodrich , Pierre Baldi

In the modern era, large volumes of data are being produced continuously, especially in domain-specific fields such as medical records and clinical files, defence logs and HTML-based web traffic. Data with such volume and complexity needs…

Information Retrieval · Computer Science 2025-08-21 Anurag Kumar Ojha

Motivation: FASTQ is a standard file format for DNA sequencing data which stores both nucleotides and quality scores. A typical sequencing study can easily generate hundreds of gigabytes of FASTQ files, while public archives such as ENA and…

Genomics · Quantitative Biology 2014-06-18 Lilian Janin , Ole Schulz-Trieglaff , Anthony J. Cox

Searching for similar genomic sequences is an essential and fundamental step in biomedical research and an overwhelming majority of genomic analyses. State-of-the-art computational methods performing such comparisons fail to cope with the…

Data Structures and Algorithms · Computer Science 2024-07-11 Mohammed Alser , Julien Eudine , Onur Mutlu
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