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We describe general characteristics of the Hodgkin-Huxley neuron's response to a periodic train of short current pulses with Gaussian noise. The deterministic neuron is bistable for antiresonant frequencies. When the stimuli arrive at the…

Biological Physics · Physics 2015-03-17 L. S. Borkowski

We analyze the response of the Morris-Lecar model to a periodic train of short current pulses in the period-amplitude plane. For a wide parameter range encompassing both class 2 and class 3 behavior in Hodgkin's classification there is a…

Biological Physics · Physics 2023-07-19 L. S. Borkowski

By extending the crude Goldman-Hodgkin-Katz electrodiffusion model for resting-state membrane potentials in perfused giant axons of squid, we reformulate the Hodgkin-Huxley (HH) phenomenological quantitative model to create a new model…

Neurons and Cognition · Quantitative Biology 2020-02-07 P. J. Stiles , C. G. Gray

We report on a theoretical study showing that the leak conductance density, $\GL$, in the squid giant axon appears to be optimal for the action potential firing frequency. More precisely, the standard assumption that the leak current is…

Neurons and Cognition · Quantitative Biology 2015-05-13 Jeffrey Seely , Patrick Crotty

We study the response of a Hodgkin-Huxley neuron stimulated by a periodic sequence of conductance pulses arriving through the synapse in the high frequency regime. In addition to the usual excitation threshold there is a smooth crossover…

Biological Physics · Physics 2010-04-08 L. S. Borkowski

The response of the Hodgkin-Huxley neuronal model subjected to stochastic uncorrelated spike trains originating from a large number of inhibitory and excitatory post-synaptic potentials is analyzed in detail. The model is examined in its…

Disordered Systems and Neural Networks · Physics 2007-05-23 Stefano Luccioli , Thomas Kreuz , Alessandro Torcini

We study the response of the Hodgkin-Huxley neuron stimulated periodically by biphasic rectangular current pulses. The optimal response for charge-balanced input is obtained for cathodic-first pulses with an inter-phase gap (IPG)…

Biological Physics · Physics 2013-05-20 L. S. Borkowski

We consider a stochastic Hodgkin-Huxley model driven by a periodic signal as model for the membrane potential of a pyramidal neuron. The associated five dimensional diffusion process is a time inhomogeneous highly degenerate diffusion for…

Probability · Mathematics 2012-07-03 Reinhard Höpfner , Eva Löcherbach , Michèle Thieullen

How is reliable physiological function maintained in cells despite considerable variability in the values of key parameters of multiple interacting processes that govern that function? Here we use the classic Hodgkin-Huxley formulation of…

Neurons and Cognition · Quantitative Biology 2018-08-20 Hillel Ori , Eve Marder , Shimon Marom

In this research, the aim is to develop a repetitive firing stopper mechanism using electrical fields exerted on the fiber. The Hodgkin - Huxley nerve fiber model is used for modeling the membrane potential behavior. The repetitive firing…

Neurons and Cognition · Quantitative Biology 2015-03-19 Resat Ozgur Doruk

In previous articles we have investigated the firing properties of the standard Hodgkin-Huxley (HH) systems of ordinary and partial differential equations in response to input currents composed of a drift (mean) and additive Gaussian white…

Neurons and Cognition · Quantitative Biology 2015-06-04 Henry C. Tuckwell , Jürgen Jost

We investigate neuronal excitability in the Hodgkin-Huxley model under temporal interference (TI) stimulation in a previously unexplored sub-Hz resonant regime and uncover a striking nonlinear response that we term 'multi-tongue frequency…

Pattern Formation and Solitons · Physics 2026-01-21 Madhurendra Mishra , Zhen Qi , Adarsh Ganesan

We numerically study dynamical behaviors of the quasiperiodically forced Hodgkin-Huxley neuron and compare the dynamical responses with those for the case of periodic stimulus. In the periodically forced case, a transition from a periodic…

Biological Physics · Physics 2011-11-08 Woochang Lim , Sang-Yoon Kim

We consider a classical space-clamped Hodgkin-Huxley model neuron stimulated by synaptic excitation and inhibition with conductances represented by Ornstein-Uhlenbeck processes. Using numerical solutions of the stochastic model system…

Neurons and Cognition · Quantitative Biology 2016-04-19 Henry C. Tuckwell , Susanne Ditlevsen

This paper presents the analytical and numerical analysis of fluctuational dynamics of ac hysteretic SQUID. It has been demonstrated, that the most important parameter for the improvement of the hysteretic SQUID sensitivity is the ratio…

Superconductivity · Physics 2009-11-07 Andrey L. Pankratov

We consider potential type dynamical systems in finite dimensions with two meta-stable states. They are subject to two sources of perturbation: a slow external periodic perturbation of period $T$ and a small Gaussian random perturbation of…

Probability · Mathematics 2007-05-23 Samuel Herrmann , Peter Imkeller , Dierk Peithmann

We study an excitable active rotator with slowly adapting nonlinear feedback and noise. Depending on the adaptation and the noise level, this system may display noise-induced spiking, noise-perturbed oscillations, or stochastic busting. We…

Adaptation and Self-Organizing Systems · Physics 2020-08-26 Igor Franović , Serhiy Yanchuk , Sebastian Eydam , Iva Bačić , Matthias Wolfrum

We consider spatially extended conductance based neuronal models with noise described by a stochastic reaction diffusion equation with additive noise coupled to a control variable with multiplicative noise but no diffusion. We only assume a…

Probability · Mathematics 2020-01-16 Martin Sauer , Wilhelm Stannat

We analyze the response of the Hodgkin-Huxley neuron to a large number of uncorrelated stochastic inhibitory and excitatory post-synaptic spike trains. In order to clarify the various mechanisms responsible for noise-induced spike…

Disordered Systems and Neural Networks · Physics 2007-05-23 Alessandro Torcini , Stefano Luccioli , Thomas Kreuz

At an optimal value of the noise intensity, the maximum variability in rebound burst durations is observed and referred to as a response stochastic incoherence. A general mechanism underlying this phenomenon is given, being different from…

Biological Physics · Physics 2010-03-23 Marzena Ciszak
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