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Statistical iterative reconstruction is expected to improve the image quality of megavoltage computed tomography (MVCT). However, one of the challenges of iterative reconstruction is its large computational cost. The purpose of this work is…

Purpose: LATTICE, a form of spatially fractionated radiation therapy that delivers high-dose peaks and low-dose valleys within the target, has been clinically utilized for treating bulky tumors. However, its application to…

Medical Physics · Physics 2025-09-08 Nimita Shinde , Weijie Zhang , Yuting Lin , Hao Gao

Spatiotemporal fractionation schemes, that is, treatments delivering different dose distributions in different fractions, may lower treatment side effects without compromising tumor control. This is achieved by hypofractionating parts of…

Medical Physics · Physics 2018-02-14 Melissa R. Gaddy , Sercan Yıldız , Jan Unkelbach , Dávid Papp

We address the challenge of real-time planning of minimum-time trajectories over multiple waypoints, onboard multirotor UAVs. Previous works demonstrated that achieving a truly time-optimal trajectory is computationally too demanding to…

Robotics · Computer Science 2024-10-01 Krystof Teissing , Matej Novosad , Robert Penicka , Martin Saska

This Article presents two optimized multi-GPU algorithms for Fock matrix construction, building on the work of Ufimtsev et al. and Barca et al. The novel algorithms, opt-UM and opt-Brc, introduce significant enhancements, including improved…

Computational Physics · Physics 2024-08-01 Elise Palethorpe , Ryan Stocks , Giuseppe M. J. Barca

Radiotherapy treatment planning is a challenging large-scale optimization problem plagued by uncertainty. Following the robust optimization methodology, we propose a novel, spatially based uncertainty set for robust modeling of radiotherapy…

Optimization and Control · Mathematics 2024-05-28 Noam Goldberg , Mark P. Langer , Shimrit Shtern

As nowadays Machine Learning (ML) techniques are generating huge data collections, the problem of how to efficiently engineer their storage and operations is becoming of paramount importance. In this article we propose a new lossless…

Data Structures and Algorithms · Computer Science 2022-03-31 Paolo Ferragina , Travis Gagie , Dominik Köppl , Giovanni Manzini , Gonzalo Navarro , Manuel Striani , Francesco Tosoni

Vectors of data are at the heart of machine learning and data mining. Recently, vector quantization methods have shown great promise in reducing both the time and space costs of operating on vectors. We introduce a vector quantization…

Performance · Computer Science 2017-07-03 Davis W Blalock , John V Guttag

Objective: Deformable image registration is a fundamental problem in medical image analysis, with applications such as longitudinal studies, population modeling, and atlas based image segmentation. Registration is often phrased as an…

Computer Vision and Pattern Recognition · Computer Science 2018-10-22 Simon Ekström , Filip Malmberg , Håkan Ahlström , Joel Kullberg , Robin Strand

Monte Carlo (MC) method has been recognized the most accurate dose calculation method for radiotherapy. However, its extremely long computation time impedes clinical applications. Recently, a lot of efforts have been made to realize fast MC…

Medical Physics · Physics 2017-02-08 Zhen Tian , Feng Shi , Michael Folkerts , Nan Qin , Steve B. Jiang , Xun Jia

We consider the effects of parameter uncertainty on the optimal radiation schedule in the context of the linear-quadratic model. Our interest arises from the observation that if inter-patient variations in OAR and tumor sensitivities to…

Tissues and Organs · Quantitative Biology 2015-06-05 Hamidreza Badri , Yoichi Watanabe , Kevin Leder

We study the problem of instance segmentation in biological images with crowded and compact cells. We formulate this task as an integer program where variables correspond to cells and constraints enforce that cells do not overlap. To solve…

Computer Vision and Pattern Recognition · Computer Science 2017-09-22 Chong Zhang , Shaofei Wang , Miguel A. Gonzalez-Ballester , Julian Yarkony

Background and purpose: IMPT faces challenges in lung cancer treatment, like maintaining plan robustness for moving tumors against setup, range errors, and interplay effects. Proton Arc Therapy (PAT) is an alternative to maintain target…

This paper presents a new fast and robust algorithm that provides fuel-optimal impulsive control input sequences that drive a linear time-variant system to a desired state at a specified time. This algorithm is applicable to a broad class…

Optimization and Control · Mathematics 2020-10-06 Adam W. Koenig , Simone D'Amico

Recently, foundation models based on Vision Transformers (ViTs) have become widely available. However, their fine-tuning process is highly resource-intensive, and it hinders their adoption in several edge or low-energy applications. To this…

Computer Vision and Pattern Recognition · Computer Science 2024-08-19 Alessio Devoto , Federico Alvetreti , Jary Pomponi , Paolo Di Lorenzo , Pasquale Minervini , Simone Scardapane

Radiation Treatment Planning (RTP) is the process of planning the appropriate external beam radiotherapy to combat cancer in human patients. RTP is a complex and compute-intensive task, which often takes a long time (several hours) to…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-09-21 Felix Liu , Niclas Jansson , Artur Podobas , Albin Fredriksson , Stefano Markidis

The selection of beam orientations, which is a key step in radiation treatment planning, is particularly challenging for non-coplanar radiotherapy systems due to the large number of candidate beams. In this paper, we report progress on the…

Medical Physics · Physics 2017-10-17 Daniel O'Connor , Yevgen Voronenko , Dan Nguyen , Wotao Yin , Ke Sheng

Accurate fluence map prediction is essential in intensity-modulated radiation therapy (IMRT) to maximize tumor coverage while minimizing dose to healthy tissues. Conventional optimization is time-consuming and dependent on planner…

Image and Video Processing · Electrical Eng. & Systems 2025-11-13 Ujunwa Mgboh , Rafi Sultan , Dongxiao Zhu , Joshua Kim

Constrained convex optimization problems arise naturally in many real-world applications. One strategy to solve them in an approximate way is to translate them into a sequence of convex feasibility problems via the recently developed level…

Optimization and Control · Mathematics 2019-04-30 E. Bonacker , A. Gibali , K. -H. Küfer

A time-optimal problem for redundantly actuated robots moving on a specified path is a challenging problem. Although the problem is well explored and there are proposed solutions based on phase plane analysis, there are still several…

Optimization and Control · Mathematics 2018-08-03 Saeed Mansouri , Mohammad Jafar Sadigh , Masoud Fazeli