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In this work, we demonstrate that Linear Discriminant Analysis (LDA) applied to atomic positions in two different states of a biomolecule produces a good reaction coordinate between those two states. Atomic coordinates of a macromolecule…

Chemical Physics · Physics 2023-05-29 Subarna Sasmal , Martin McCullagh , Glen M. Hocky

Unraveling the dynamical motions of biomolecules is essential for bridging their structure and function, yet it remains a major computational challenge. Molecular dynamics (MD) simulation provides a detailed depiction of biomolecular…

Biomolecules · Quantitative Biology 2025-09-17 Allan dos Santos Costa , Manvitha Ponnapati , Dana Rubin , Tess Smidt , Joseph Jacobson

A central concern of molecular dynamics simulations are the potential energy surfaces that govern atomic interactions. These hypersurfaces define the potential energy of the system, and have generally been calculated using either predefined…

Computational Physics · Physics 2019-07-05 Emir Kocer , Jeremy K. Mason , Hakan Erturk

This paper introduces SiQAD, a computer-aided design tool enabling the rapid design and simulation of atomic silicon dangling bond quantum dot patterns capable of computational logic. Several simulation tools are included, each able to…

The identification of the interfacial molecules in fluid-fluid equilibrium is a long-standing problem in the area of simulation. We here propose a new point of view, making use of concepts taken from the field of computational geometry,…

Soft Condensed Matter · Physics 2009-04-30 Florencio Balboa Usabiaga , Daniel Duque

Computation of biological processes creates great promise for everyday life and great challenges for physical scientists. Simulations of molecular dynamics appeal to biologists as a natural extension of structural biology. Once biologists…

Biomolecules · Quantitative Biology 2019-03-05 Bob Eisenberg

Molecular dynamics (MD) simulations are useful in obtaining thermodynamic and kinetic properties of bio-molecules but are limited by the timescale barrier, i.e., we may be unable to efficiently obtain properties because we need to run…

Chemical Physics · Physics 2017-08-23 Surl-Hee Ahn , Jay W. Grate , Eric F. Darve

In this paper we study the realization of lattice models in mixtures of atomic and dipolar molecular quantum gases. We consider a situation where polar molecules form a self-assembled dipolar lattice, in which atoms or molecules of a second…

Other Condensed Matter · Physics 2015-05-13 M. Ortner , A. Micheli , G. Pupillo , P. Zoller

Massively-parallel molecular dynamics simulation is applied to systems containing electrolytes, vapour-liquid interfaces, and biomolecules in contact with water-oil interfaces. Novel molecular models of alkali halide salts are presented and…

A model for the simulation of orientational effects in straight and bent periodic atomic structures is presented. The continuum potential approximation has been adopted.The model allows the manipulation of particle trajectories by means of…

Computational Physics · Physics 2014-10-02 E. Bagli , M. Asai , D. Brandt , A. Dotti , V. Guidi , D. H. Wright

We study cavity optomechanics of a mixture of ultracold atoms with tunable nonlinear collisions. We show that atomic collisions provide linear couplings between fictitious condensate oscillators, leading to possibilities of achieving a…

Quantum Physics · Physics 2012-12-07 H. Jing , X. Zhao , L. F. Buchmann

Molecular dynamics (MD) simulation is a powerful tool for studying biomolecular structural changes, molecular recognition, transmembrane transport, and functional mechanisms. However, its practical bottleneck lies not only in software…

Quantitative Methods · Quantitative Biology 2026-04-22 Zhenyu Ma , Chunyi Yang , Yuyang Song , Jingyi Zhu , Letian Yang , Limei Xu , Min Xiao , Xukai Jiang

We formulate and analyze an optimization-based Atomistic-to-Continuum (AtC) coupling method for problems with point defects. Near the defect core the method employs a potential-based atomistic model, which enables accurate simulation of the…

Numerical Analysis · Mathematics 2014-11-17 Derek Olson , Alexander V. Shapeev , Pavel Bochev , Mitchell Luskin

Representing a strongly interacting multi-particle wave function in a finite product basis leads to errors. Simple rescaling of the contact interaction can preserve the low-lying energy spectrum and long-wavelength structure of wave…

Quantum Gases · Physics 2011-08-23 Thomas Ernst , David W. Hallwood , Jake Gulliksen , Hans-Dieter Meyer , Joachim Brand

We review achievements made in recent years in the field of numerical modeling of ultra-relativistic projectiles propagation in oriented crystals, radiation emission and related phenomena. This topic is highly relevant to the problem of…

Accelerator Physics · Physics 2023-05-17 Andrei V. Korol , Gennady B. Sushko , Andrey V. Solov'yov

The ever-increasing power of supercomputers coupled with highly scalable simulation codes have made molecular dynamics an indispensable tool in applications ranging from predictive modeling of materials to computational design and discovery…

Computational Engineering, Finance, and Science · Computer Science 2020-02-25 Henry Chan , Badri Narayanan , Mathew Cherukara , Troy D. Loeffler , Michael G. Sternberg , Anthony Avarca , Subramanian K. R. S. Sankaranarayanan

Continual Test-Time Adaptation (CTTA) is proposed to migrate a source pre-trained model to continually changing target distributions, addressing real-world dynamism. Existing CTTA methods mainly rely on entropy minimization or…

Computer Vision and Pattern Recognition · Computer Science 2024-03-28 Jiaming Liu , Ran Xu , Senqiao Yang , Renrui Zhang , Qizhe Zhang , Zehui Chen , Yandong Guo , Shanghang Zhang

A new class of matching condition between the atomistic and continuum regions is presented for the multi-scale modeling of crystals. They ensure the accurate passage of large scale information between the atomistic and continuum regions and…

Materials Science · Physics 2009-11-07 Weinan E , Zhongyi Huang

Path integral-based simulation methodologies play a crucial role for the investigation of nuclear quantum effects by means of computer simulations. However, these techniques are significantly more demanding than corresponding classical…

Statistical Mechanics · Physics 2018-01-17 Karsten Kreis , Kurt Kremer , Raffaello Potestio , Mark E. Tuckerman

Molecular dynamics (MD) simulations and computer-aided drug design (CADD) have advanced substantially over the past two decades, thanks to continuous computer hardware and software improvements. Given these advancements, MD simulations are…

Quantitative Methods · Quantitative Biology 2023-11-29 Mayar Ahmed , Alex M. Maldonado , Jacob D. Durrant