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Fluctuations in the abundance of molecules in the living cell may affect its growth and well being. For regulatory molecules (e.g., signaling proteins or transcription factors), fluctuations in their expression can affect the levels of…

Molecular Networks · Quantitative Biology 2009-11-13 Erel Levine , Terence Hwa

Circadian rhythmicity lies at the center of various important physiological and behavioral processes in mammals, such as sleep, metabolism, homeostasis, mood changes and more. It has been shown that this rhythm arises from self-sustained…

Neurons and Cognition · Quantitative Biology 2023-02-08 Yorgos M. Psarellis , Michail Kavousanakis , Michael A. Henson , Ioannis G. Kevrekidis

The beneficial role of noise-injection in learning is a consolidated concept in the field of artificial neural networks, suggesting that even biological systems might take advantage of similar mechanisms to optimize their performance. The…

Disordered Systems and Neural Networks · Physics 2024-06-04 Marco Benedetti , Enrico Ventura

From spiking activity in neuronal networks to force chains in granular materials, the behavior of many real-world systems depends on a network of both strong and weak interactions. These interactions give rise to complex and higher-order…

Quantitative Methods · Quantitative Biology 2021-01-12 Ann S. Blevins , Jason Z. Kim , Danielle S. Bassett

Large networks of sparsely coupled, excitatory and inhibitory cells occur throughout the brain. A striking feature of these networks is that they are chaotic. How does this chaos manifest in the neural code? Specifically, how variable are…

Neurons and Cognition · Quantitative Biology 2014-02-25 Guillaume Lajoie , Jean-Philippe Thivierge , Eric Shea-Brown

Diversity conveys advantages in nature, yet homogeneous neurons typically comprise the layers of artificial neural networks. Here we construct neural networks from neurons that learn their own activation functions, quickly diversify, and…

Machine Learning · Computer Science 2023-09-01 Anshul Choudhary , Anil Radhakrishnan , John F. Lindner , Sudeshna Sinha , William L. Ditto

Neural networks (NN)-based learning algorithms are strongly affected by the choices of initialization and data distribution. Different optimization strategies have been proposed for improving the learning trajectory and finding a better…

Machine Learning · Computer Science 2021-03-19 Yimeng Min

We consider the problem of identifying the most influential nodes for a spreading process on a network when prior knowledge about structure and dynamics of the system is incomplete or erroneous. Specifically, we perform a numerical analysis…

Physics and Society · Physics 2018-10-09 Şirag Erkol , Ali Faqeeh , Filippo Radicchi

Deep Neural Networks (DNNs) have revolutionized a wide range of industries, from healthcare and finance to automotive, by offering unparalleled capabilities in data analysis and decision-making. Despite their transforming impact, DNNs face…

Machine Learning · Computer Science 2024-02-08 Zhenyu Liu , Garrett Gagnon , Swagath Venkataramani , Liu Liu

This work proposes a learning-based statistical refinement method for improving the denoising results of a given denoiser without knowing the precise noise distribution or accessing clean images or calibration data. While there are many…

Machine Learning · Computer Science 2026-05-07 Rihuan Ke

Large genomic and imaging datasets can be used to train models that learn meaningful representations of cellular systems. Across domains, model performance improves predictably with dataset size and compute budget, providing a basis for…

Quantitative Methods · Quantitative Biology 2026-02-23 Gokul Gowri , Igor Sadalski , Dan Raviv , Peng Yin , Jonathan Rosenfeld , Allon M. Klein

Spiking Neural Networks (SNNs) represent the forefront of neuromorphic computing, promising energy-efficient and biologically plausible models for complex tasks. This paper weaves together three groundbreaking studies that revolutionize SNN…

Neural and Evolutionary Computing · Computer Science 2024-07-10 Biswadeep Chakraborty , Saibal Mukhopadhyay

Kinetics of a balanced network of neurons with a sparse grid of synaptic links is well representable by the stochastic dynamics of a generic neuron subject to an effective shot noise. The rate of delta-pulses of the noise is determined…

Neurons and Cognition · Quantitative Biology 2025-10-31 Maria V. Ageeva , Denis S. Goldobin

Stochastic resonance holds much promise for the detection of weak signals in the presence of relatively loud noise. Following the discovery of nondynamical and of aperiodic stochastic resonance, it was recently shown that the phenomenon can…

Condensed Matter · Physics 2009-10-31 Redouane Fakir

Cellular behaviors such as migration, division, and differentiation rely on precise timing, and yet the molecular events that govern these behaviors are highly stochastic. We investigate regulatory strategies that decrease the timing noise…

Biological Physics · Physics 2020-07-01 Shivam Gupta , Sean Fancher , Hendrik C. Korswagen , Andrew Mugler

Recent research demonstrate that prediction of time series by predictive recurrent neural networks based on the noisy input generates a smooth anticipated trajectory. We examine influence of the noise component in both the training data…

Machine Learning · Computer Science 2023-05-02 Boris Rubinstein

In this paper we suggest a new algorithm for determination of signal-to-noise ratio (SNR). SNR is a quantitative measure widely used in science and engineering. Generally, methods for determination of SNR are based on using of…

Data Analysis, Statistics and Probability · Physics 2016-09-30 Z. Zh. Zhanabaev , S. N. Akhtanov , E. T. Kozhagulov , B. A Karibayev

Noise is a part of data whether the data is from measurement, experiment or ... A few techniques are suggested for noise reduction to improve the data quality in recent years some of which are based on wavelet, orthogonalization and neural…

Computational Engineering, Finance, and Science · Computer Science 2023-08-02 Negin Bagherpour , Abbas Mohammadiyan

Single-cell studies often show significant phenotypic variability due to the stochastic nature of intra-cellular biochemical reactions. When the numbers of molecules, e.g., transcription factors and regulatory enzymes, are in low abundance,…

Quantitative Methods · Quantitative Biology 2015-06-17 Kyung Hyuk Kim , Hong Qian , Herbert M. Sauro

Exploiting the information provided by the molecular noise of a biological process has proven to be valuable in extracting knowledge about the underlying kinetic parameters and sources of variability from single cell measurements. However,…

Quantitative Methods · Quantitative Biology 2013-08-30 Jakob Ruess , Andreas Milias-Argeitis , John Lygeros
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