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Translocation of a single stranded DNA through genetically engineered $\alpha$-hemolysin channels with positively charged walls is studied. It is predicted that transport properties of such channels are dramatically different from neutral…

Subcellular Processes · Quantitative Biology 2008-09-10 Tao Hu , B. I. Shklovskii

Lectures deal with the theory of electronic transport, in particular with the electrical conductivity, in systems dominated by strong electron-electron repulsion. The concept of charge stiffness is introduced to distinguish conductors and…

Strongly Correlated Electrons · Physics 2009-11-07 P. Prelovsek , X. Zotos

Cooperativity plays an important role in the action of proteins bound to DNA. A simple, mechanical mechanism for cooperativity, in the form of a tension-mediated interaction between proteins bound to DNA at two different locations is…

Soft Condensed Matter · Physics 2009-10-31 Joseph Rudnick , Robijn Bruinsma

The sequence-dependent elasticity of double-helical DNA on a nm length scale can be captured by the rigid base-pair model, whose strains are the relative position and orientation of adjacent base-pairs. Corresponding elastic potentials have…

Biomolecules · Quantitative Biology 2013-05-29 Nils B. Becker , Ralf Everaers

Polymer translocation is a promising strategy for the next-generation DNA sequencing technologies. The use of biological and synthetic nano-pores, however, still suffers from serious drawbacks. In particular, the width of the membrane layer…

Soft Condensed Matter · Physics 2017-11-30 Timothee Menais , Stefano Mossa , Arnaud Buhot

A tight-binding model together with a novel statistical method are used to investigate the relation between the sequence-dependent electric transport properties and the sequences of protein-coding regions of complete genomes. A correlation…

Biological Physics · Physics 2009-11-11 C. T. Shih

Electronic conduction in conjugated polymers is of emerging technological interest for high-performance optoelectronic and thermoelectric devices. A completely new aspect and understanding of the conduction mechanism on conducting polymers…

Materials Science · Physics 2015-08-18 Asli Ugur , Ferhat Katmis , Mingda Li , Lijun Wu , Yimei Zhu , Kripa K. Varanasi , Karen K. Gleason

The effect of mispair on charge transport in a DNA of sequence (GC)(TA)_N(GC)_3 connected to platinum electrodes is studied using the tight-binding model. With parameters derived from ab initio density functional result, we calculate the…

Mesoscale and Nanoscale Physics · Physics 2012-02-10 Xue-Feng Wang , Tapash Chakraborty , J. Berashevich

Debates about conductivity of DNAs have been recently renewed due to contradictory results of direct measurements by use of electrical contacts to molecules. In several works it was discovered that double-stranded (ds)DNAs are conductors:…

Condensed Matter · Physics 2007-05-23 A. Yu. Kasumov , D. V. Klinov

A rapid and low-cost method to sequence DNA would usher in a revolution in medicine. We propose and theoretically show the feasibility of a protocol for sequencing based on the distributions of transverse electrical currents of…

Soft Condensed Matter · Physics 2015-06-25 Johan Lagerqvist , Michael Zwolak , Massimiliano Di Ventra

The zero-temperature transmission rate spectrum of a double-chain tight-binding model for real DNA is calculated. It is shown that a band of extended-like states exists only for finite chain length with strong inter-chain coupling. While…

Disordered Systems and Neural Networks · Physics 2009-11-11 Gang Xiong , X. R. Wang

We investigate the dynamics of DNA translocation through a nanopore using 2D Langevin dynamics simulations, focusing on the dependence of the translocation dynamics on the details of DNA sequences. The DNA molecules studied in this work are…

Soft Condensed Matter · Physics 2008-02-05 Kaifu Luo , Tapio Ala-Nissila , See-Chen Ying , Aniket Bhattacharya

The photoelectron properties of DNA and RNA bases are studied using many-body perturbation theory within the GW approximation, together with a recently developed Lanczos-chain approach. Calculated vertical ionization potentials, electron…

Materials Science · Physics 2015-03-19 Xiaofeng Qian , Paolo Umari , Nicola Marzari

A versatile approach to modeling the conformations and energetics of DNA loops is presented. The model is based on the classical theory of elasticity, modified to describe the intrinsic twist and curvature of DNA, the DNA bending…

Biological Physics · Physics 2007-05-23 Alexander Balaeff , L. Mahadevan , Klaus Schulten

Simple elastic network models of DNA were developed to reveal the structure-dynamics relationships for several nucleotide sequences. First, we propose a simple all-atom elastic network model of DNA that can explain the profiles of…

Biological Physics · Physics 2016-02-17 Shuhei Isami , Naoaki Sakamoto , Hiraku Nishimori , Akinori Awazu

Although mechanical properties of DNA are well characterized at the kilo base-pair range, a number of recent experiments have suggested that DNA is more flexible at shorter length scales, which correspond to the regime that is crucial for…

Biomolecules · Quantitative Biology 2015-06-11 Agnes Noy , Ramin Golestanian

Two models for energy and charge transport and storage in biomolecules are considered. A model based on the discrete nonlinear Schrodinger equation with long-range dispersive interactions (LRI's) between base pairs of DNA is offered for the…

We present a first-principle study of the electronic and conduction properties of a few classes of nanowires constituted of guanine (G) molecules, self-assembled in different geometries. We first analyze the effect of the vertical…

Soft Condensed Matter · Physics 2009-11-10 Arrigo Calzolari , Rosa Di Felice , Elisa Molinari

We study the transport properties of two electrons in a quasi one-dimensional disordered wire. The electrons are subject to both, a disorder potential and a short range two-body interaction. Using the approach developed by Iida et al. […

Disordered Systems and Neural Networks · Physics 2009-11-07 Jean Richert , Hans A. Weidenmuller

The competition between toroidal and rod-like conformations as possible ground states for DNA condensation is studied as a function of the stiffness, the length of the DNA and the form of the long-range interactions between neighboring…