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Purpose: To improve target coverage and reduce the dose in the surrounding organs-at-risks (OARs), we developed an image-guided treatment method based on a precomputed library of treatment plans controlled and delivered in real-time.…

Medical Physics · Physics 2022-11-02 Valentin Hamaide , Kevin Souris , Damien Dasnoy , Francois Glineur , Benoit Macq

Gradient-based trajectory optimization (GTO) has gained wide popularity for quadrotor trajectory replanning. However, it suffers from local minima, which is not only fatal to safety but also unfavorable for smooth navigation. In this paper,…

Robotics · Computer Science 2020-04-17 Boyu Zhou , Fei Gao , Jie Pan , Shaojie Shen

Challenging the Nvidia monopoly, dedicated AI-accelerator chips have begun emerging for tackling the computational challenge that the inference and, especially, the training of modern deep neural networks (DNNs) poses to modern computers.…

Machine Learning · Computer Science 2023-02-01 Lennart P. L. Landsmeer , Max C. W. Engelen , Rene Miedema , Christos Strydis

Inverse optimization (IO) algorithms are used in GYN HDR brachytherapy planning, with user parameter settings embedded in commercial TPS. To examine the dosimetric influence of hidden input parameters in three IO algorithms-IPSA, HIPO, and…

Medical Physics · Physics 2026-01-09 YeongHyeon Park , Shiqin Su , Sarath Vijayan , Zhiqian Henry Yu , Mandy Cunningham , Yusung Kim

Deep learning-based methods have revolutionized the field of imaging inverse problems, yielding state-of-the-art performance across various imaging domains. The best performing networks incorporate the imaging operator within the network…

Computer Vision and Pattern Recognition · Computer Science 2026-01-06 Romain Vo , Julián Tachella

Cardiac resynchronization therapy (CRT) is a common intervention for patients with dyssynchronous heart failure, yet approximately one-third of recipients fail to respond, partly due to suboptimal lead placement. Identifying optimal pacing…

Computational Engineering, Finance, and Science · Computer Science 2026-02-13 Ehsan Naghavi , Haifeng Wang , Vahid Ziaei Rad , Julius Guccione , Ghassan Kassab , Vishnu Boddeti , Seungik Baek , Lik-Chuan Lee

Background: Multi-collimator proton minibeam radiation therapy (MC-pMBRT) has recently emerged as a versatile technique for dose shaping, enabling peak-valley dose patterns in organs-at-risk (OAR) while maintaining a uniform dose…

Medical Physics · Physics 2025-02-25 Nimita Shinde , Weijie Zhang , Yuting Lin , Hao Gao

Recent studies suggest that gradient-based methods applied to relaxed box-constrained Quadratic Unconstrained Binary Optimization (QUBO) formulations can outperform classical heuristics in some large-scale regimes, often relying on heavy…

Discrete Mathematics · Computer Science 2026-05-11 Yongliang Sun , Ismail Alkhouri , Cheng-Han Huang , Alvaro Velasquez , Susmit Jha , Rongrong Wang

Adaptive Mesh Refinement (AMR) enables efficient computation of flows by providing high resolution in critical regions while allowing for coarsening in areas where fine detail is unnecessary. While early AMR software packages relied solely…

Computational Physics · Physics 2025-02-26 Khodr Jaber , Ebenezer Essel , Pierre Sullivan

Accurate characterization of glioma is crucial for clinical decision making. A delineation of the tumor is also desirable in the initial decision stages but is a time-consuming task. Leveraging the latest GPU capabilities, we developed a…

Optimizing the advertiser's cumulative value of winning impressions under budget constraints poses a complex challenge in online advertising, under the paradigm of AI-Generated Bidding (AIGB). Advertisers often have personalized objectives…

Artificial Intelligence · Computer Science 2026-01-22 Mingxuan Song , Yusen Huo , Bohan Zhou , Shenglin Yin , Zhen Xiao , Jieyi Long , Zhilin Zhang , Chuan Yu

We propose to develop deep learning models that can predict Pareto optimal dose distributions by using any given set of beam angles, along with patient anatomy, as input to train the deep neural networks. We implement and compare two deep…

Medical Physics · Physics 2021-01-27 Gyanendra Bohara , Azar Sadeghnejad Barkousaraie , Steve Jiang , Dan Nguyen

Clawpack is a library for solving nonlinear hyperbolic partial differential equations using high-resolution finite volume methods based on Riemann solvers and limiters. It supports Adaptive Mesh Refinement (AMR), which is essential in…

Mathematical Software · Computer Science 2018-08-09 Xinsheng Qin , Randall J. LeVeque , Michael R. Motley

Background: Proton arc therapy is an emerging radiation therapy technique where either the gantry or the patient continuously rotates during the irradiation treatment. One of the perceived advantages of proton arc therapy is the reduced…

Medical Physics · Physics 2023-10-20 Viktor Wase , Otte Marthin , Albin Fredriksson , Anton Finnson

Solving the shallow water equations efficiently is critical to the study of natural hazards induced by tsunami and storm surge, since it provides more response time in an early warning system and allows more runs to be done for…

Computational Physics · Physics 2019-01-23 Xinsheng Qin , Randall LeVeque , Michael Motley

Radiation therapy is considered to be one of important treatment protocols for cancers. Radiation therapy employs several beams of ionizing radiation to kill cancer tumors, but such irradiation also causes damage to normal tissues.…

Optimization and Control · Mathematics 2016-12-06 Shogo Kishimoto , Makoto Yamashita

Stereotactic body radiotherapy (SBRT) is characterized by delivering a high amount of dose in a short period of time. In SBRT the dose is delivered using open fields (e.g., beam's-eye-view) known as "apertures". Mathematical methods can be…

Medical Physics · Physics 2015-06-15 Hamed Yarmand , David Craft

Radiation therapy treatment planning can be viewed as an iterative hyperparameter tuning process to balance conflicting clinical goals. In this work, we investigated the performance of modern Bayesian Optimization (BO) methods on automated…

Medical Physics · Physics 2023-02-15 Qingying Wang , Ruoxi Wang , Jiacheng Liu , Fan Jiang , Haizhen Yue , Yi Du , Hao Wu

Finding a realistic deformation that transforms one image into another, in case large deformations are required, is considered a key challenge in medical image analysis. Having a proper image registration approach to achieve this could…

Computer Vision and Pattern Recognition · Computer Science 2023-03-10 Georgios Andreadis , Peter A. N. Bosman , Tanja Alderliesten

When dealing with giga-pixel digital pathology in whole-slide imaging, a notable proportion of data records holds relevance during each analysis operation. For instance, when deploying an image analysis algorithm on whole-slide images…

Image and Video Processing · Electrical Eng. & Systems 2023-08-22 Haoju Leng , Ruining Deng , Shunxing Bao , Dazheng Fang , Bryan A. Millis , Yucheng Tang , Haichun Yang , Xiao Wang , Yifan Peng , Lipeng Wan , Yuankai Huo
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