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Many natural and industrial processes rely on constrained transport, such as proteins moving through cells, particles confined in nanocomposite materials or gels, individuals in highly dense collec- tives and vehicular traffic conditions.…

Membrane bending is an extensively studied problem from both modeling and experimental perspectives because of the wide implications of curvature generation in cell biology. Many of the curvature generating aspects in membranes can be…

Soft Condensed Matter · Physics 2021-07-21 Arijit Mahapatra , David Saintillan , Padmini Rangamani

Transport across heterogeneous, patchy environments is a ubiquitous phenomenon spanning fields of study including ecological movement, intracellular transport and regions of specialised function in a cell. These regions or patches may be…

Statistical Mechanics · Physics 2017-10-06 Sergei Fedotov , Helena Stage

Many transport processes in nature exhibit anomalous diffusive properties with non-trivial scaling of the mean square displacement, e.g., diffusion of cells or of biomolecules inside the cell nucleus, where typically a crossover between…

Statistical Mechanics · Physics 2015-09-16 Andrea Cairoli , Adrian Baule

We present a model for diffusion in a molecularly crowded environment. The model consists of random barriers in percolation network. Random walks in the presence of slowly moving barriers show normal diffusion for long times, but anomalous…

Subcellular Processes · Quantitative Biology 2007-06-06 Dietrich Stauffer , Christian Schulze , Dieter W. Heermann

Anomalous diffusion occurs in a wide range of systems, including protein transport within cells, animal movement in complex habitats, pollutant dispersion in groundwater, and nanoparticle motion in synthetic materials. Accurately estimating…

Computer Vision and Pattern Recognition · Computer Science 2025-04-08 Yusef Ahsini , Marc Escoto , J. Alberto Conejero

Anomalous diffusion often arises in complex environments where viscoelastic or crowded conditions influence particle motion. In many biological and soft-matter systems, distinct components of the medium exhibit unique viscoelastic…

Soft Condensed Matter · Physics 2026-01-05 Chan Lim , Jae-Hyung Jeon

Measurements of lateral diffusion of proteins in a membrane typically assume that the movement of the protein occurs in a flat plane. Real membranes, however, are subject to thermal fluctuations, leading to movement of an inclusion into the…

Soft Condensed Matter · Physics 2007-05-23 E. Reister , U. Seifert

We consider the hydrodynamics of lipid bilayers containing transmembrane proteins of arbitrary shape. This biologically-motivated problem is relevant to the cell membrane, whose fluctuating dynamics play a key role in phenomena ranging from…

Soft Condensed Matter · Physics 2016-10-10 Andrew Callan-Jones , Marc Durand , Jean-Baptiste Fournier

Cell membranes phase separate into ordered ${\rm L_o}$ and disordered ${\rm L_d}$ domains depending on their compositions. This membrane compartmentalization is heterogeneous and regulates the localization of specific proteins related to…

Soft Condensed Matter · Physics 2023-08-11 Ken Sakamoto , Takuma Akimoto , Mayu Muramatsu , Mark S. P. Sansom , Ralf Metzler , Eiji Yamamoto

We investigate the dynamics of a particle moving randomly along a disordered hetero-polymer subjected to rapid conformational changes which induce superdiffusive motion in chemical coordinates. We study the antagonistic interplay between…

Statistical Mechanics · Physics 2009-11-10 D. Brockmann , T. Geisel

We present analytical results for the biased diffusion of particles moving under a constant force in a randomly layered medium. The influence of this medium on the particle dynamics is modeled by a piecewise constant random force. The…

Statistical Mechanics · Physics 2010-02-10 S. I. Denisov , H. Kantz

We investigate theoretically the behavior of proteins as well as other large macromolecules which are incorporated into amphiphilic monolayers at the air-water interface. We assume the monolayer to be in the coexistence region of the…

Soft Condensed Matter · Physics 2007-05-23 R. R. Netz , D. Andelman , H. Orland

Restrictions to molecular motion by barriers (membranes) are ubiquitous in biological tissues, porous media and composite materials. A major challenge is to characterize the microstructure of a material or an organism nondestructively using…

Soft Condensed Matter · Physics 2011-03-11 Dmitry S. Novikov , Els Fieremans , Jens H. Jensen , Joseph A. Helpern

The physical approach of a small particle (virus, medical drug) to the cell membrane represents the crucial first step before active internalization and is governed by thermal diffusion. Using a fully analytical theory we show that the…

Fluid Dynamics · Physics 2016-02-17 Abdallah Daddi-Moussa-Ider , Achim Guckenberger , Stephan Gekle

Uchaikin suggested a mathematical model of an anomalous diffusion in a space was suggested. This model origins in an investigation of processes in complex systems with variable structure: glasses, liquid crystals, biopolymers, proteins and…

Probability · Mathematics 2007-05-23 G. Sh. Tsitsiashvili , A. E. Yashin

From the perspective of physical properties, the cell membrane is an exotic two-dimensional material that has a dual nature: it exhibits characteristics of fluids, i.e., lipid molecules show lateral diffusion, while also demonstrating…

Soft Condensed Matter · Physics 2024-04-19 Vikash Pandey , Dhrubaditya Mitra

Heterogeneous media diffusion is often described using position-dependent diffusion coefficients and estimated indirectly through mean squared displacement in experiments. This approach may overlook other mechanisms and their interaction…

Statistical Mechanics · Physics 2023-09-11 Haroldo V. Ribeiro , Angel A. Tateishi , Ervin K. Lenzi , Richard L. Magin , Matjaz Perc

Local diffusion coefficients in disordered systems such as spin glass systems and living cells are highly heterogeneous and may change over time. Such a time-dependent and spatially heterogeneous environment results in irreproducibility of…

Statistical Mechanics · Physics 2016-12-21 Takuma Akimoto , Eiji Yamamoto

The diffusion of a particle in a crowded environment typically proceeds through three regimes: for very short times the particle diffuses freely until it collides with an obstacle for the first time, while for very long times diffusion the…

Biological Physics · Physics 2019-10-09 Nguiya P. Neo , Gary W. Slater