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In this paper we extend our recent work on two-dimensional (2D) diffusive search-and-capture processes with multiple small targets (narrow capture problems) by considering an asymptotic expansion of the Laplace transformed probability flux…

Statistical Mechanics · Physics 2021-04-28 Paul C Bressloff

When using the boundary integral equation method to solve a boundary value problem, the evaluation of the solution near the boundary is challenging to compute because the layer potentials that represent the solution are nearly-singular…

Numerical Analysis · Mathematics 2018-10-08 Camille Carvalho , Shilpa Khatri , Arnold D. Kim

Questions of flux regulation in biological cells raise renewed interest in the narrow escape problem. The often inadequate expansions of the narrow escape time are due to a not so well known fact that the boundary singularity of Green's…

Mathematical Physics · Physics 2009-11-13 A. Singer , Z. Schuss , D. Holcman

We consider the transmission eigenvalue problem for an impenetrable obstacle with Dirichlet boundary condition surrounded by a thin layer of non-absorbing inhomogeneous material. We derive a rigorous asymptotic expansion for the first…

Analysis of PDEs · Mathematics 2013-12-06 Fioralba Cakoni , Nicolas Chaulet , Houssem Haddar

We develop an asymptotic analysis of target fluxes in the three-dimensional (3D) narrow capture problem. The latter concerns a diffusive search process in which the targets are much smaller than the size of the search domain. The small…

Statistical Mechanics · Physics 2020-11-18 Paul C Bressloff

We probe the application of the calculus of conormal distributions, in particular the Pull-Back and Push-Forward Theorems, to the method of layer potentials to solve the Dirichlet and Neumann problems on half-spaces. We obtain full…

Analysis of PDEs · Mathematics 2017-12-29 Karsten Fritzsch

This paper investigates a diffusion process in a narrow tubular domain with reflecting boundary conditions, where the geometry serves as a singular perturbation of an underlying graph in $\mathbb{R}^2$ or $\mathbb{R}^3$. The construction…

Probability · Mathematics 2025-09-04 Wen-Tai Hsu

We study the evaluation of layer potentials close to the domain boundary. Accurate evaluation of layer potentials near boundaries is needed in many applications, including fluid-structure interactions and near-field scattering in…

Numerical Analysis · Mathematics 2017-12-06 Camille Carvalho , Shilpa Khatri , Arnold D Kim

A general topic of current interest is the analysis of diffusion problems in singularly perturbed domains with small interior targets or traps (the narrow capture problem). One major application is to intracellular diffusion, where the…

Statistical Mechanics · Physics 2022-04-13 Paul C. Bressloff

In this article, we derive the asymptotic expansion, up to an arbitrary order in theory, for the solution of a two-dimensional elliptic equation with strongly anisotropic diffusion coefficients along different directions, subject to the…

Analysis of PDEs · Mathematics 2017-01-13 Ling Lin , Xiang Zhou

The narrow escape problem arises in deriving the asymptotic expansion of the solution of an inhomogeneous mixed Dirichlet-Neumann boundary value problem. In this paper, we mainly deal with narrow escape problem in a smooth domain connected…

Analysis of PDEs · Mathematics 2014-03-04 Xiaofei Li

We present an efficient method to solve the narrow capture and narrow escape problems for the sphere. The narrow capture problem models the equilibrium behavior of a Brownian particle in the exterior of a sphere whose surface is reflective,…

Numerical Analysis · Mathematics 2021-08-03 Jason Kaye , Leslie Greengard

In this paper we propose and validate a multiscale model for the description of particle diffusion in presence of trapping boundaries. We start from a drift-diffusion equation in which the drift term describes the effect of bubble traps,…

Numerical Analysis · Mathematics 2023-07-11 Clarissa Astuto , Antonio Raudino , Giovanni Russo

This paper considers the two-dimensional narrow escape problem in a domain which is composed of a relatively big head and several thin necks. The narrow escape problem is to compute the mean first passage time(MFPT) of a Brownian particle…

Mathematical Physics · Physics 2023-12-05 Xiaofei Li , Shengqi Lin

We consider the problem of determining escape probabilities from an interval of a general compound renewal process with drift. This problem is reduced to the solution of a certain integral equation. In an actuarial situation where only…

Probability · Mathematics 2019-07-30 Javier Villarroel , Juan A. Vega , Miquel Montero

We present a numerical method for the solution of diffusion problems in unbounded planar regions with complex geometries of absorbing and reflecting bodies. Our numerical method applies the Laplace transform to the parabolic problem,…

Numerical Analysis · Mathematics 2024-08-19 Jesse Cherry , Alan E. Lindsay , Bryan D. Quaife

This paper complements the existing theory developed in [5] for the Dirichlet and Neumann problems for the Laplace equation, in multiply connected domains. Within the framework of layer potential methods, we study the Laplace equation under…

Analysis of PDEs · Mathematics 2026-02-18 Alberto Cialdea , Vita Leonessa

We consider a singular perturbed eigenvalue problem for Laplace operator in a cylinder with frequent interchange of type of boundary condition on a lateral surface. These boundary conditions are prescribed by partition of lateral surface in…

Mathematical Physics · Physics 2007-05-23 Denis I. Borisov

Boundary integral equations are an efficient and accurate tool for the numerical solution of elliptic boundary value problems. The solution is expressed as a layer potential; however, the error in its evaluation grows large near the…

Numerical Analysis · Mathematics 2013-10-22 Alex H. Barnett

When a flux of Brownian particles is injected in a narrow window located on the surface of a bounded domain, these particles diffuse and can eventually escape through a cluster of narrow windows. At steady-state, we compute asymptotically…

Analysis of PDEs · Mathematics 2024-07-31 Frédéric Paquin-Lefebvre , David Holcman
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