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Periodic boundary conditions are commonly applied in molecular dynamics simulations in the microcanonical (NVE), canonical (NVT) and isothermal-isobaric (NpT) ensembles. In their simplest application, a biological system of interest is…

Soft Condensed Matter · Physics 2023-06-09 Radek Erban , Yuichi Togashi

Understanding the behavior of biomolecules such as proteins requires understanding the critical influence of the surrounding fluid (solvent) environment--water with mobile salt ions such as sodium. Unfortunately, for many studies, fully…

Soft Condensed Matter · Physics 2015-05-27 J. P. Bardhan , D. A. Tejani , N. S. Wieckowski , A. Ramaswamy , M. G. Knepley

Deformable elastic bodies in viscous and viscoelastic media constitute a large portion of synthetic and biological complex fluids. We present a parallelized 3D-simulation methodology which fully resolves the momentum balance in the solid…

Computational Physics · Physics 2019-03-11 Amir Saadat , Chris J. Guido , Gianluca Iaccarino , Eric S. G. Shaqfeh

Computational fluid dynamics (CFD) studies have been increasingly used for blood flow simulations in intracranial aneurysms (ICAs). However, despite the continuous progress of body-fitted CFD solvers, generating a high quality mesh is still…

Computational Engineering, Finance, and Science · Computer Science 2020-07-28 D. S. Lampropoulos , G. C. Bourantas , B. F. Zwick , G. C. Kagadis , A. Wittek , K. Miller , V. C. Loukopoulos

We have studied by Molecular Dynamics computer simulations the dynamics of water confined in ionic surfactants phases, ranging from well ordered lamellar structures to micelles at low and high water loading, respectively. We have analysed…

Soft Condensed Matter · Physics 2016-03-23 Samuel Hanot , Sandrine Lyonnard , Stefano Mossa

We present a comparison of methods for treating the electrostatic interactions of finite, isolated systems within periodic boundary conditions (PBCs), within Density Functional Theory (DFT), with particular emphasis on linear-scaling (LS)…

Computational Physics · Physics 2011-12-07 N. D. M. Hine , J. Dziedzic , P. D. Haynes , C. K. Skylaris

In transient simulations of particulate Stokes flow, to accurately capture the interaction between the constituent particles and the confining wall, the discretization of the wall often needs to be locally refined in the region approached…

Numerical Analysis · Mathematics 2022-01-10 Yabin Zhang , Adrianna Gillman , Shravan Veerapaneni

Precise prediction of phase diagrams in molecular dynamics (MD) simulations is challenging due to the simultaneous need for long time scales, large length scales and accurate interatomic potentials. We show that thermodynamic integration…

Materials Science · Physics 2023-06-06 Tanooj Shah , Kamron Fazel , Jie Lian , Liping Huang , Yunfeng Shi , Ravishankar Sundararaman

We explore a new way to handle flux boundary conditions imposed on level sets. The proposed approach is a diffuse interface version of the shifted boundary method (SBM) for continuous Galerkin discretizations of conservation laws in…

Numerical Analysis · Mathematics 2022-05-11 Dmitri Kuzmin , Jan-Phillip Bäcker

We present an efficient and accurate immersed boundary (IB) finite element (FE) solver for numerically solving incompressible Navier--Stokes equations. Particular emphasis is given to internal flows with complex geometries (blood flow in…

Computational Engineering, Finance, and Science · Computer Science 2020-07-07 G. C. Bourantas , D. L. Lampropoulos , B. F. Zwick , V. C. Loukopoulos , A. Wittek , K. Miller

-Molecular simulations allow the study of properties and interactions of molecular systems. This article presents an improved version of the Adaptive Resolution Scheme that links two systems having atomistic (also called fine-grained) and…

Computational Engineering, Finance, and Science · Computer Science 2017-08-01 Iuliana Marin , Virgil Tudose , Anton Hadar , Nicolae Goga , Andrei Doncescu

Continuum solvent models have become a standard technique in the context of electronic structure calculations, yet, no implementations have been reported capable to perform molecular dynamics at solid-liquid interfaces. We propose here such…

Chemical Physics · Physics 2015-05-13 Veronica M. Sanchez , Mariela Sued , Damian A. Scherlis

In this paper we develop a stochastic boundary conditions (SBC) for event-driven molecular dynamics simulations of a finite volume embedded within an infinite environment. In this method, we first collect the statistics of…

Computational Physics · Physics 2011-12-21 M. Prusty , S. A. Cheong

The structure and function of biological molecules are strongly influenced by the water and dissolved ions that surround them. This aqueous solution (solvent) exerts significant electrostatic forces in response to the biomolecule's…

Numerical Analysis · Mathematics 2015-12-29 Matthew G. Knepley , Jaydeep P. Bardhan

Understanding protein dynamics are essential for deciphering protein functional mechanisms and developing molecular therapies. However, the complex high-dimensional dynamics and interatomic interactions of biological processes pose…

Quantitative Methods · Quantitative Biology 2025-05-15 Tiexin Qin , Mengxu Zhu , Chunyang Li , Terry Lyons , Hong Yan , Haoliang Li

Dynamics simulations of constrained particles can greatly aid in understanding the temporal and spatial evolution of biological processes such as lateral transport along membranes and self-assembly of viruses. Most theoretical efforts in…

Computational Physics · Physics 2017-03-03 Stefan Paquay , Remy Kusters

The immersed boundary (IB) method is a non-body conforming approach to fluid-structure interaction (FSI) that uses an Eulerian description of the momentum, viscosity, and incompressibility of a coupled fluid-structure system and a…

Numerical Analysis · Mathematics 2022-02-18 Jae H. Lee , Boyce E. Griffith

Like many other biological processes, calcium dynamics in neurons containing an endoplasmic reticulum are governed by diffusion-reaction equations on interface-separated domains. Interface conditions are typically described by systems of…

Numerical Analysis · Mathematics 2022-03-14 Qingguang Guan , Gillian Queisser

Molecular dynamics simulations have been performed on pure liquid water, aqueous solutions of sodium chloride, and polymer solutions exposed to a strong external electric field with the goal to gain molecular insight into the structural…

Soft Condensed Matter · Physics 2016-08-08 I. Nezbeda , J. Jirsák , F. Moučka , W. R. Smith

The wetting dynamics of liquid particles, from coated droplets to soft capsules, holds significant technological interest. Motivated by the need to simulate liquid metal droplet with an oxidize surface layer, in this work we introduce a…

Fluid Dynamics · Physics 2024-02-14 Francesca Pelusi , Fabio Guglietta , Marcello Sega , Othmane Aouane , Jens Harting