Related papers: Bifurcation analysis for a free boundary problem m…
In the present work we consider the mathematical model that describes brain tumour growth (glioblastomas) under medical treatment. Based on the medical study presented by R. Stupp et al. (New Engl Journal of Med 352: 987-996, 2005) which…
We report on a simple model of spatial extend anti-tumor system with a fluctuation in growth rate, which can undergo a nonequilibrium phase transition. Three states as excited, sub-excited and non-excited states of a tumor are defined to…
We briefly review the properties of radially growing interfaces and their connection to biological growth. We focus on simplified models which result from the abstraction of only considering domain growth and not the interface curvature.…
We consider the Taylor-Couette problem in an infinitely extended cylindrical domain. There exist modulated front solutions which describe the spreading of the stable Taylor vortices into the region of the unstable Couette flow. These…
We propose a numerical method to approximate viscosity solutions of fully nonlinear free transmission problems. The method discretises a two-layer regularisation of a PDE, involving a functional and a vanishing parameter. The former is…
In this paper, we study a phase field model for a tumor growth model of Cahn--Hilliard type in which the often assumed parabolic relaxation of the chemical potential is replaced by a hyperbolic one. We show that the resulting…
In this paper we present a study of local dynamics of the growth of cancer tumor and healthy cells considering the presence of nutrients in the system. We also analyze the evolution of system if we take indirectly into account the level of…
In this article we establish the exact growth of the solution to the singular quasilinear p-parabolic free boundary problem in non-divergence form near the free boundary from which follows its porosity.
Free boundary problems are those described by PDEs that exhibit a priori unknown (free) interfaces or boundaries. These problems appear in Physics, Probability, Biology, Finance, or Industry, and the study of solutions and free boundaries…
We present a mathematical model describing oncolytic virotherapy treatment of a tumour that proliferates according to a Gompertz growth function. We present local stability analysis and bifurcation plots for relevant model parameters to…
We prove that bounded solutions to an overdetermined fully nonlinear free boundary problem in the plane are one dimensional. Our proof relies on maximum principle techniques and convexity arguments.
Existence of nontrivial nonnegative equilibrium solutions for age structured population models with nonlinear diffusion is investigated. Introducing a parameter measuring the intensity of the fertility, global bifurcation is shown of a…
In this study, we model avascular tumour growth in epithelial tissue. This can help us to get a macroscopic view of the interaction between the tumour with its surrounding microenvironment and the physical changes within the tumour…
In the present article we demonstrate a new hybrid model of tumor growth. Our model is stochastic by tumor population development and strongly deterministic in cell motility dynamics and spatial propagation. In addition, it has excellent…
We study an equation governed by a discontinuous fully nonlinear operator. Such discontinuities are solution-dependent, which introduces a free boundary. Working under natural assumptions, we prove the existence of $L^p$-viscosity and…
Stationary bifurcations in several nonlinear models of fluid conveying pipes fixed at both ends are analyzed with the use of Lyapunov-Schmidt reduction and singularity theory. Influence of gravitational force, curvature and vertical elastic…
We consider a model of axisymmetric flows for a free boundary vortex embedded in a statically stable fluid at rest. We identify the boundary of the vortex by solving a variational problem. Then, we reduce the analysis of the dynamics of the…
We consider the asymptotic limit of a diffuse interface model for tumor-growth when a parameter $\varepsilon$ proportional to the thickness of the diffuse interface goes to zero. An approximate solution which shows explicitly the behavior…
We develop and analyze a model for a flat microbial droplet growing on the surface of a three-dimensional viscous fluid. The model describes growth-induced stresses at the fluid surface, density variations in the bulk due to nutrient…
We analyze a phase field model for tumor growth consisting of a Cahn-Hilliard-Brinkman system, ruling the evolution of the tumor mass, coupled with an advection-reaction-diffusion equation for a chemical species acting as a nutrient. The…