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A significant drawback of Lagrangian (particle-tracking) reactive transport models has been their inability to properly simulate interactions between solid and liquid chemical phases, such as dissolution and precipitation reactions. This…

The presence of energy barriers in the state space of a physical system can lead to exponentially slow convergence for sampling algorithms like Markov chain Monte Carlo (MCMC). In the classical setting, replica exchange (or parallel…

Quantum Physics · Physics 2025-12-01 Zherui Chen , Joao Basso , Zhiyan Ding , Lin Lin

Path sampling allows the study of rare events like chemical reactions, nucleation and protein folding via a Monte Carlo (MC) exploration in path space. Instead of configuration points, this method samples short molecular dynamics (MD)…

Chemical Physics · Physics 2023-01-25 Daniel T. Zhang , Enrico Riccardi , Titus S. van Erp

We propose an efficient novel path sampling-based framework designed to accelerate the investigation of rare events in complex molecular systems. A key innovation is the shift from sampling restricted path ensemble distributions, as in…

Chemical Physics · Physics 2025-03-28 Gianmarco Lazzeri , Peter G. Bolhuis , Roberto Covino

We investigate the purification dynamics of a single qubit under continuous in time monitoring. By employing a collisional model framework where the system interacts sequentially with ancillary qubits, we describe the conditioned evolution…

Quantum Physics · Physics 2026-05-14 Matheus M. R. Poltronieri Martins , Henrique Santos Lima

In this work, we propose a path integral-inspired formalism for computing the quantum thermal expectation values of spin systems, when subject to magnetic fields that can be time-dependent and can accommodate the presence of Heisenberg…

Quantum Physics · Physics 2025-06-18 Thomas Nussle , Stam Nicolis , Iason Sofos , Joseph Barker

Biological sensory systems, from \textit{E.~coli} chemotaxis to sensory neurons in \textit{C.~elegans}, achieve reliable adaptation over wide dynamic ranges despite operating in strongly noisy and overdamped regimes. Here, we present a…

Statistical Mechanics · Physics 2026-02-12 Gunn Kim

We investigate a quantitative network of gene expression dynamics describing the competence development in Bacillus subtilis. First, we introduce an Onsager-Machlup approach to quantify the most probable transition pathway for both…

Molecular Networks · Quantitative Biology 2022-04-27 Jianyu Hu , Xiaoli Chen , Jinqiao Duan

In this paper, we analyse a proximal method based on the idea of forward-backward splitting for sampling from distributions with densities that are not necessarily smooth. In particular, we study the non-asymptotic properties of the…

Numerical Analysis · Mathematics 2022-01-25 Armin Eftekhari , Luis Vargas , Konstantinos Zygalakis

We introduce the use of the Zig-Zag sampler to the problem of sampling conditional diffusion processes (diffusion bridges). The Zig-Zag sampler is a rejection-free sampling scheme based on a non-reversible continuous piecewise deterministic…

Statistics Theory · Mathematics 2024-09-04 Joris Bierkens , Sebastiano Grazzi , Frank van der Meulen , Moritz Schauer

We develop a new Lagrangian approach --- flow dynamic approach to effectively capture the interface in the Allen-Cahn type equations. The underlying principle of this approach is the Energetic Variational Approach (EnVarA), motivated by…

Numerical Analysis · Mathematics 2020-08-26 Q. Cheng , Chun liu , J. Shen

We provide a new paradigm for quantum simulation that is based on path integration that allows quantum speedups to be observed for problems that are more naturally expressed using the path integral formalism rather than the conventional…

Quantum Physics · Physics 2024-10-15 Serene Shum , Nathan Wiebe

While gradient-based discrete samplers are effective in sampling from complex distributions, they are susceptible to getting trapped in local minima, particularly in high-dimensional, multimodal discrete distributions, owing to the…

Machine Learning · Statistics 2025-05-21 Luxu Liang , Yuhang Jia , Feng Zhou

For a nonlinear stochastic path planning problem, sampling-based algorithms generate thousands of random sample trajectories to find the optimal path while guaranteeing safety by Lagrangian penalty methods. However, the sampling-based…

Systems and Control · Electrical Eng. & Systems 2021-11-16 Chuyuan Tao , Hunmin Kim , Hyungjin Yoon , Naira Hovakimyan , Petros Voulgaris

The efficiency of path sampling simulations can be improved considerably using the approach of path swapping. For this purpose, we have devised a new algorithmic procedure based on the transition interface sampling technique. In the same…

Statistical Mechanics · Physics 2009-11-13 Titus S. van Erp

We introduce a novel framework for efficient sampling from complex, unnormalised target distributions by exploiting multiscale dynamics. Traditional score-based sampling methods either rely on learned approximations of the score function or…

Computation · Statistics 2025-11-04 Paula Cordero-Encinar , Andrew B. Duncan , Sebastian Reich , O. Deniz Akyildiz

Merging into dense highway traffic for an autonomous vehicle is a complex decision-making task, wherein the vehicle must identify a potential gap and coordinate with surrounding human drivers, each of whom may exhibit diverse driving…

We propose two efficient algorithms for configurational sampling of systems with rough energy landscape. The first one is a new method for the determination of the multicanonical weight factor. In this method a short replica-exchange…

Statistical Mechanics · Physics 2009-10-31 Yuji Sugita , Yuko Okamoto

We explore exchange coupling of a pair of spins in a double dot and in an optical lattice. Our algorithm uses the frequency of exchanges in a bosonic path integral, evaluated with Monte Carlo. This algorithm is simple enough to be a "black…

Strongly Correlated Electrons · Physics 2010-07-27 Lei Zhang , Matthew Gilbert , Jesper Pedersen , John Shumway

Importance sampling of trajectories has proved a uniquely successful strategy for exploring rare dynamical behaviors of complex systems in an unbiased way. Carrying out this sampling, however, requires an ability to propose changes to…

Statistical Mechanics · Physics 2015-07-01 Todd R. Gingrich , Phillip L. Geissler