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We introduce methods for discovering and applying sparse feature circuits. These are causally implicated subnetworks of human-interpretable features for explaining language model behaviors. Circuits identified in prior work consist of…

Machine Learning · Computer Science 2025-03-28 Samuel Marks , Can Rager , Eric J. Michaud , Yonatan Belinkov , David Bau , Aaron Mueller

Many natural signals exhibit a sparse representation, whenever a suitable describing model is given. Here, a linear generative model is considered, where many sparsity-based signal processing techniques rely on such a simplified model. As…

Machine Learning · Computer Science 2013-06-11 Mehrdad Yaghoobi , Laurent Daudet , Michael E. Davies

Inspired by the use of random projections in biological sensing systems, we present a new algorithm for processing data in classification problems. This is based on observations of the human brain and the fruit fly's olfactory system and…

Machine Learning · Statistics 2022-07-28 Nina Dekoninck Bruhin , Bryn Davies

Living cells communicate information about physiological conditions by producing signaling molecules in a specific timed manner. Different conditions can result in the same total amount of a signaling molecule, differing only in the pattern…

Molecular Networks · Quantitative Biology 2018-10-09 Jackson O'Brien , Arvind Murugan

Multiple-objective optimization is common in biological systems. In the mammalian olfactory system, each sensory neuron stochastically expresses only one out of up to thousands of olfactory receptor (OR) gene alleles; at organism level the…

Molecular Networks · Quantitative Biology 2016-05-11 Xiao-Jun Tian , Hang Zhang , Jens Sannerud , Jianhua Xing

Tabular datasets with low-sample-size or many variables are prevalent in biomedicine. Practitioners in this domain prefer linear or tree-based models over neural networks since the latter are harder to interpret and tend to overfit when…

Machine Learning · Computer Science 2022-02-09 Junchen Yang , Ofir Lindenbaum , Yuval Kluger

Hair cells, the sensory receptors of the internal ear, subserve different functions in various receptor organs: they detect oscillatory stimuli in the auditory system, but transduce constant and step stimuli in the vestibular and…

Neurons and Cognition · Quantitative Biology 2017-03-29 Joshua D. Salvi , Daibhid O Maoileidigh , Brian A. Fabella , Melanie Tobin , A. J. Hudspeth

Olfaction, the sense of smell, has received scant attention from a signal processing perspective in comparison to audition and vision. In this paper, we develop a signal processing paradigm for olfactory signals based on new scientific…

Information Theory · Computer Science 2015-09-16 Kush R. Varshney , Lav R. Varshney

Olfaction -- how molecules are perceived as odors to humans -- remains poorly understood. Recently, the principal odor map (POM) was introduced to digitize the olfactory properties of single compounds. However, smells in real life are not…

Machine Learning · Computer Science 2025-01-28 Gary Tom , Cher Tian Ser , Ella M. Rajaonson , Stanley Lo , Hyun Suk Park , Brian K. Lee , Benjamin Sanchez-Lengeling

Molecular communication (MC) has promising potential and a wide range of applications. However, odor-based communication which is common in nature, has not been sufficiently examined within the context of MC, yet. In this paper, we…

Emerging Technologies · Computer Science 2024-11-01 Fatih E. Bilgen , Ahmet B. Kilic , Ozgur B. Akan

Given the structure of a novel molecule, there is still no one who can reliably predict what odor percept that molecule will evoke. The challenge comes from both the difficulty in quantitatively characterizing molecular structure, and the…

Neurons and Cognition · Quantitative Biology 2018-06-08 Daniel Kepple , Alexei Koulakov

Sparsity is a desirable attribute. It can lead to more efficient and more effective representations compared to the dense model. Meanwhile, learning sparse latent representations has been a challenging problem in the field of computer…

Computer Vision and Pattern Recognition · Computer Science 2022-09-22 Hanao Li , Tian Han

Recent experimental and theoretical work on neural populations belonging to two separate early sensory systems, olfaction and vision, has challenged the notion that the two operate under different computational paradigms by providing…

Quantitative Methods · Quantitative Biology 2018-08-14 William T Redman

It is now well established that sparse signal models are well suited to restoration tasks and can effectively be learned from audio, image, and video data. Recent research has been aimed at learning discriminative sparse models instead of…

Computer Vision and Pattern Recognition · Computer Science 2009-09-29 Julien Mairal , Francis Bach , Jean Ponce , Guillermo Sapiro , Andrew Zisserman

This chapter focuses on active sensing using sparse arrays. In active sensing applications, such as radar, sonar, wireless communications, and medical ultrasound, a collection of sensors probes the environment by emitting self-generated…

Signal Processing · Electrical Eng. & Systems 2026-01-22 Robin Rajamäki , Visa Koivunen

The high-level concepts that a neural network uses to perform computation need not be aligned to individual neurons (Smolensky, 1986). Language model interpretability research has thus turned to techniques such as \textit{sparse…

Computation and Language · Computer Science 2026-02-02 Aryaman Arora , Zhengxuan Wu , Jacob Steinhardt , Sarah Schwettmann

Until today, the exact function of mammalian odorant binding proteins (OBPs) remains a topic of debate. Although their main established function lacks direct evidence in human olfaction, OBPs are traditionally believed to act as odorant…

Biomolecules · Quantitative Biology 2025-07-08 Mifen Chen , Soufyan Lakbir , Mihyeon Jeon , Vojta Mazur , Sanne Abeln , Halima Mouhib

Molecular odor prediction has great potential across diverse fields such as chemistry, pharmaceuticals, and environmental science, enabling the rapid design of new materials and enhancing environmental monitoring. However, current methods…

Machine Learning · Computer Science 2025-02-04 HongXin Xie , JianDe Sun , Yi Shao , Shuai Li , Sujuan Hou , YuLong Sun , Yuxiang Liu

Determining how synaptic coupling within and between regions is modulated during sensory processing is an important topic in neuroscience. Electrophysiological recordings provide detailed information about neural spiking but have…

Neurons and Cognition · Quantitative Biology 2018-02-07 Andrea K. Barreiro , Shree Hari Gautam , Woodrow L. Shew , Cheng Ly

This paper investigates a discontinuous neural network which is used as a model of the mammalian olfactory system and can more generally be applied to solve non-negative sparse approximation problems. By inherently limiting the systems…

Neural and Evolutionary Computing · Computer Science 2016-03-22 Martijn Arts , Marius Cordts , Monika Gorin , Marc Spehr , Rudolf Mathar