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With the launch of second line anti-retroviral therapy for HIV infected individuals, there has been an increased expectation on surviving period of people with HIV. We consider previously well-known models in HIV epidemiology where the…

Quantitative Methods · Quantitative Biology 2021-06-15 Arni S. R. Srinivasa Rao

We present a practical guide for the analysis of regression discontinuity (RD) designs in biomedical contexts. We begin by introducing key concepts, assumptions, and estimands within both the continuity-based framework and the local…

Methodology · Statistics 2023-05-17 Matias D. Cattaneo , Luke Keele , Rocio Titiunik

High-dimensional vector autoregression with measurement error is frequently encountered in a large variety of scientific and business applications. In this article, we study statistical inference of the transition matrix under this model.…

Methodology · Statistics 2020-09-18 Xiang Lyu , Jian Kang , Lexin Li

Conformal predictors, introduced by Vovk et al. (2005), serve to build prediction intervals by exploiting a notion of conformity of the new data point with previously observed data. In the present paper, we propose a novel method for…

Statistics Theory · Mathematics 2009-02-12 Mohamed Hebiri

Proportionate type algorithms were developed and excessively used in the echo cancellation problems due to sparse characteristics of the echo channels. In the past, most of the attention was paid to a particular type of proportionate…

Signal Processing · Electrical Eng. & Systems 2021-07-09 Murat Babek Salman , Tolga Ciloglu

If error distribution has heteroscedasticity, it voliates the assumption of linear regression. Expectile regression is a powerful tool for estimating the conditional expectiles of a response variable in this setting. Since multiple levels…

Methodology · Statistics 2022-08-03 Jinghang Lin , Yuan Huang , Shuangge Ma

We aim to incorporate variable selection routines into variable-by-variable (or sequential) imputation in clustered data to achieve computational improvement in applications with large-scale health data. Specifically, we utilize variable…

Methodology · Statistics 2025-04-08 Qiushuang Li , Recai Yucel

In many practical settings one can sequentially and adaptively guide the collection of future data, based on information extracted from data collected previously. These sequential data collection procedures are known by different names,…

Statistics Theory · Mathematics 2013-11-28 Ervin Tánczos , Rui M. Castro

Structured additive distributional regression models offer a versatile framework for estimating complete conditional distributions by relating all parameters of a parametric distribution to covariates. Although these models efficiently…

Methodology · Statistics 2023-11-14 Jana Kleinemeier , Nadja Klein

Conformalized quantile regression is a procedure that inherits the advantages of conformal prediction and quantile regression. That is, we use quantile regression to estimate the true conditional quantile and then apply a conformal step on…

Machine Learning · Statistics 2023-11-02 Martim Sousa , Ana Maria Tomé , José Moreira

Many biological high-throughput data sets, such as targeted amplicon-based and metagenomic sequencing data, are compositional in nature. A common exploratory data analysis task is to infer statistical associations between the…

Methodology · Statistics 2020-07-28 Aditya Mishra , Christian L. Muller

Few Bayesian methods for analyzing high-dimensional sparse survival data provide scalable variable selection, effect estimation and uncertainty quantification. Such methods often either sacrifice uncertainty quantification by computing…

Methodology · Statistics 2022-07-06 Michael Komodromos , Eric Aboagye , Marina Evangelou , Sarah Filippi , Kolyan Ray

Although spatial prediction is widely used for urban and environmental monitoring, its accuracy is often unsatisfactory if only a small number of samples are available in the study area. The objective of this study was to improve the…

Applications · Statistics 2022-11-22 Daisuke Murakami , Mami Kajita , Seiji Kajita

The progressive hedging algorithm (PHA) is a cornerstone among algorithms for large-scale stochastic programming problems. However, its traditional implementation is hindered by some limitations, including the requirement to solve all…

Optimization and Control · Mathematics 2025-03-13 Di Zhang , Yihang Zhang , Suvrajeet Sen

I consider unsupervised extensions of the fast stepwise linear regression algorithm \cite{efroymson1960multiple}. These extensions allow one to efficiently identify highly-representative feature variable subsets within a given set of…

Machine Learning · Computer Science 2017-06-13 Jonathan Landy

We in this paper propose a directional regression based approach for ultrahigh dimensional sufficient variable screening with censored responses. The new method is designed in a model-free manner and thus can be adapted to various complex…

Methodology · Statistics 2018-02-28 Menghao Xu , Zhou Yu , Jun Shao

Cytotoxic T-lymphocytes (CTLs) recognize viral protein fragments displayed by major histocompatibility complex (MHC) molecules on the surface of virally infected cells and generate an anti-viral response that can kill the infected cells.…

Populations and Evolution · Quantitative Biology 2014-03-25 Taylor A. Kessinger , Alan S. Perelson , Richard A. Neher

We introduce a new methodology 'charcoal' for estimating the location of sparse changes in high-dimensional linear regression coefficients, without assuming that those coefficients are individually sparse. The procedure works by…

Statistics Theory · Mathematics 2023-05-23 Fengnan Gao , Tengyao Wang

The evolutionary dynamics of HIV during the chronic phase of infection is driven by the host immune response and by selective pressures exerted through drug treatment. To understand and model the evolution of HIV quantitatively, the…

Populations and Evolution · Quantitative Biology 2012-08-01 Richard A. Neher , Thomas Leitner

Prediction with the possibility of abstention (or selective prediction) is an important problem for error-critical machine learning applications. While well-studied in the classification setup, selective approaches to regression are much…

Machine Learning · Statistics 2023-09-29 Fedor Noskov , Alexander Fishkov , Maxim Panov