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A reaction network together with a choice of rate constants uniquely gives rise to a system of differential equations, according to the law of mass-action kinetics. On the other hand, different networks can generate the same dynamical…

Dynamical Systems · Mathematics 2021-05-18 Gheorghe Craciun , Jiaxin Jin , Polly Y. Yu

The Jacobian matrix of a dynamic system and its principal minors play a prominent role in the study of qualitative dynamics and bifurcation analysis. When interpreting the Jacobian as an adjacency matrix of an interaction graph, its…

Molecular Networks · Quantitative Biology 2012-10-02 Hans-Michael Kaltenbach

The objective of this paper is to study the dynamical behaviour systematically of an ecological system with Beddington-DeAngelis functional response which avoids the criticism occurred in the case of ratio-dependent functional response at…

Dynamical Systems · Mathematics 2015-01-21 Sahabuddin Sarwardi , Md. Reduanur Mandal , Nurul Huda Gazi

Many biological processes are supported by special molecules, called motor proteins or molecular motors, that transport cellular cargoes along linear protein filaments and can reversibly associate to their tracks. Stimulated by these…

Statistical Mechanics · Physics 2021-11-17 Akriti Jindal , Anatoly B. Kolomeisky , Arvind Kumar Gupta

Metastability is a physical phenomenon ubiquitous in first order phase transitions. A fruitful mathematical way to approach this phenomenon is the study of rare transitions Markov chains. For Metropolis chains associated with Statistical…

Probability · Mathematics 2015-09-30 Emilio Cirillo , Francesca Nardi , Julien Sohier

The numerical solutions of nonlocal and local Boltzmann kinetic equations for the simulation of central heavy ion reactions are parameterized in terms of time dependent thermodynamical variables in the Fermi liquid sense. This allows one to…

Nuclear Theory · Physics 2009-11-06 Klaus Morawetz

The appearance of so-called exceptional points in the complex spectra of non-Hermitian systems is often associated with phenomena that contradict our physical intuition. One example of particular interest is the state-exchange process…

The dynamics of flow within a material transport network is dependent upon the dynamics of its power source. Responding to a change of these dynamics is critical for the fitness of living flow networks, e.g. the animal vasculature, which…

Fluid Dynamics · Physics 2021-09-29 Sean Fancher , Eleni Katifori

We investigate classes of interacting systems that allow for a mapping to disordered noninteracting systems. As we show, such a mapping is possible for interacting systems with a suppressed density of states at the chemical potential,…

Mesoscale and Nanoscale Physics · Physics 2023-11-16 Shijun Sun , Sergey Syzranov

Stochastic reaction networks are mathematical models with a wide range of applications in biochemistry, ecology, and epidemiology, and are often complex to analyze. Except for some special cases, it is generally difficult to predict how the…

Probability · Mathematics 2026-04-02 Daniele Cappelletti , Giulio Cuniberti , Paola Siri

Recent developments in automated tracking allow uninterrupted, high-resolution recording of animal trajectories, sometimes coupled with the identification of stereotyped changes of body pose or other behaviors of interest. Analysis and…

Populations and Evolution · Quantitative Biology 2018-07-04 Katarina Bodova , Gabriel J. Mitchell , Roy Harpaz , Elad Schneidman , Gasper Tkacik

The well-known Deficiency One Theorem gives structural conditions on a chemical reaction network under which, for any set of parameter values, the steady states of the corresponding mass action system may be easily characterized. It is also…

Optimization and Control · Mathematics 2016-03-02 Matthew D. Johnston

It is well known that the addition of noise to a multistable dynamical system can induce random transitions from one stable state to another. For low noise, the times between transitions have an exponential tail and Kramers' formula gives…

Dynamical Systems · Mathematics 2017-11-15 Peter Ashwin , Jennifer Creaser , Krasimira Tsaneva-Atanasova

Bistability is a major mechanism for cellular decision making and usually results from positive feedback in biochemical control systems. Here we show theoretically that bistability between unbound and bound states of adhesion clusters…

Subcellular Processes · Quantitative Biology 2010-02-24 T. Erdmann , U. S. Schwarz

In binary cascade dynamics, the nodes of a graph are in one of two possible states (inactive, active), and nodes in the inactive state make an irreversible transition to the active state, as soon as their precursors satisfy a predetermined…

Physics and Society · Physics 2018-03-16 Edward Laurence , Jean-Gabriel Young , Sergey Melnik , Louis J. Dubé

Electromagnetic relays and solenoid actuators are commonly used for their bistable behavior, which allows for switching between two states in electrical, pneumatic, or hydraulic circuits, among other applications. Although there has been…

Systems and Control · Electrical Eng. & Systems 2025-04-25 Edgar Ramirez-Laboreo , Carlos Sagues , Eduardo Moya-Lasheras , Eloy Serrano-Seco

Neuronal networks alternate between high- and low-activity regimes, known as up and down states. They also display rhythmic patterns essential for perception, memory consolidation, and sensory processing. Despite their importance, the…

Neurons and Cognition · Quantitative Biology 2025-07-22 Kateryna Nechyporenko , Peter Ashwin , Krasimira Tsaneva-Atanasova

Drastic change in dynamics and statistics in a chemical reaction system, induced by smallness in the molecule number, is reported. Through stochastic simulations for random catalytic reaction networks, transition to a novel state is…

Adaptation and Self-Organizing Systems · Physics 2009-11-13 Akinori Awazu , Kunihiko Kaneko

Species interactions through cross-feeding via leakage and uptake of chemicals are important in microbial communities, and play an essential role in the coexistence of diverse species. Here, we study a simple dynamical model of a microbial…

Biological Physics · Physics 2026-02-02 Takashi Shimada , Kunihiko Kaneko

We discuss the symbolic dynamics of biochemical networks with separate timescales. We show that symbolic dynamics of monomolecular reaction networks with separated rate constants can be described by deterministic, acyclic automata with a…

Molecular Networks · Quantitative Biology 2015-07-07 Ovidiu Radulescu , Satya Swarup Samal , Aurélien Naldi , Dima Grigoriev , Andreas Weber