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The rapid growth in literature accumulates diverse and yet comprehensive biomedical knowledge hidden to be mined such as drug interactions. However, it is difficult to extract the heterogeneous knowledge to retrieve or even discover the…

Computation and Language · Computer Science 2021-01-26 Lei Huang , Jiecong Lin , Xiangtao Li , Linqi Song , Ka-Chun Wong

Aligning protein interaction networks (PPI) of two or more organisms consists of finding a mapping of the nodes (proteins) of the networks that captures important structural and functional associations (similarity). It is a well studied but…

Molecular Networks · Quantitative Biology 2020-10-12 Concettina Guerra , Pietro Hiram Guzzi

The aim of this paper is to report on a novel text reduction technique, called Text Denoising, that highlights information-rich content when processing a large volume of text data, especially from the biomedical domain. The core feature of…

Information Retrieval · Computer Science 2013-08-02 Rushdi Shams

Large pre-trained language models have been shown to encode large amounts of world and commonsense knowledge in their parameters, leading to substantial interest in methods for extracting that knowledge. In past work, knowledge was…

Computation and Language · Computer Science 2021-03-12 Adi Haviv , Jonathan Berant , Amir Globerson

The worldwide surge of multiresistant microbial strains has propelled the search for alternative treatment options. The study of Protein-Protein Interactions (PPIs) has been a cornerstone in the clarification of complex physiological and…

Understanding how molecular alterations propagate across biological systems to drive disease remains a central challenge. Although high-throughput profiling enables comprehensive characterization of tumor states, most models neglect…

Quantitative Methods · Quantitative Biology 2026-05-11 Kyle Higgins , Guadalupe Gonzalez , Dennis Veselkov , Ivan Laponogov , Kirill Veselkov

Protein-protein interaction (PPI) modeling has been widely studied as a binary or multi-label classification task. While emerging multimodal large language models (LLMs) can now describe single proteins, they remain unable to generate…

Computational Engineering, Finance, and Science · Computer Science 2026-05-12 Xiao Fei , Sarah Almeida Carneiro , Yang Zhang , Lawrence P. Petalidis , Achilleas Tsortos , Costas Bouyioukos , Michalis Vazirgiannis

The fast-growing number of research articles makes it problematic for scholars to keep track of the new findings related to their areas of expertise. Furthermore, linking knowledge across disciplines in rapidly developing fields becomes…

Computation and Language · Computer Science 2024-07-04 Sofia Gil-Clavel , Tatiana Filatova

Business Process Modeling projects often require formal process models as a central component. High costs associated with the creation of such formal process models motivated many different fields of research aimed at automated generation…

Computation and Language · Computer Science 2024-04-12 Julian Neuberger , Leonie Doll , Benedict Engelmann , Lars Ackermann , Stefan Jablonski

Text simplification seeks to improve readability while retaining the original content and meaning. Our study investigates whether pre-trained classifiers also maintain such coherence by comparing their predictions on both original and…

Computation and Language · Computer Science 2024-04-11 Miriam Anschütz , Edoardo Mosca , Georg Groh

Pre-trained large language models can perform natural language processing downstream tasks by conditioning on human-designed prompts. However, a prompt-based approach often requires "prompt engineering" to design different prompts,…

Computation and Language · Computer Science 2024-05-28 Mingyang Song , Yi Feng , Liping Jing

The study of multi-type Protein-Protein Interaction (PPI) is fundamental for understanding biological processes from a systematic perspective and revealing disease mechanisms. Existing methods suffer from significant performance degradation…

Machine Learning · Computer Science 2021-06-02 Guofeng Lv , Zhiqiang Hu , Yanguang Bi , Shaoting Zhang

Computational synthesis planning approaches have achieved recent success in organic chemistry, where tabulated synthesis procedures are readily available for supervised learning. The syntheses of inorganic materials, however, exist…

Computation and Language · Computer Science 2017-11-29 Sheshera Mysore , Edward Kim , Emma Strubell , Ao Liu , Haw-Shiuan Chang , Srikrishna Kompella , Kevin Huang , Andrew McCallum , Elsa Olivetti

Text simplification has emerged as an increasingly useful application of AI for bridging the communication gap in specialized fields such as medicine, where the lexicon is often dominated by technical jargon and complex constructs. Despite…

Computation and Language · Computer Science 2023-10-27 Lorenzo Jaime Yu Flores , Heyuan Huang , Kejian Shi , Sophie Chheang , Arman Cohan

A major obstacle to the development of Natural Language Processing (NLP) methods in the biomedical domain is data accessibility. This problem can be addressed by generating medical data artificially. Most previous studies have focused on…

Computation and Language · Computer Science 2019-08-09 Zixu Wang , Julia Ive , Sumithra Velupillai , Lucia Specia

Information Retrieval (IR) is an important application area of Natural Language Processing (NLP) where one encounters the genuine challenge of processing large quantities of unrestricted natural language text. While much effort has been…

cmp-lg · Computer Science 2008-02-03 Chengxiang Zhai

Simultaneous administration of multiple drugs can have synergistic or antagonistic effects as one drug can affect activities of other drugs. Synergistic effects lead to improved therapeutic outcomes, whereas, antagonistic effects can be…

Computation and Language · Computer Science 2017-08-15 Sunil Kumar Sahu , Ashish Anand

Peptides play a pivotal role in a wide range of biological activities through participating in up to 40% protein-protein interactions in cellular processes. They also demonstrate remarkable specificity and efficacy, making them promising…

Biomolecules · Quantitative Biology 2024-02-09 Song Yin , Xuenan Mi , Diwakar Shukla

Aspect-based sentiment classification (ABSC) is a very challenging subtask of sentiment analysis (SA) and suffers badly from the class-imbalance. Existing methods only process sentences independently, without considering the domain-level…

Computation and Language · Computer Science 2022-02-22 Zhenxin Wu , Jiazheng Gong , Kecen Guo , Guanye Liang , Qingliang Che , Bo Liu

Abundant and diverse data on medicines manufacturing and other lifecycle components has been made easily accessible in the last decades. However, a significant proportion of this information is characterised by not being tabulated and…

Information Retrieval · Computer Science 2025-05-02 Diego Alvarado-Maldonado , Blair Johnston , Cameron J. Brown
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