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We implement a well-established concept to consider dispersion effects within a Poisson-Boltzmann approach of continuum solvation of proteins. The theoretical framework is particularly suited for boundary element methods. Free parameters…

Biological Physics · Physics 2007-11-28 Parimal Kar , Max Seel , Ulrich H. E. Hansmann , Siegfried Hoefinger

The article addresses a long-standing open problem on the justification of using variational Bayes methods for parameter estimation. We provide general conditions for obtaining optimal risk bounds for point estimates acquired from…

Statistics Theory · Mathematics 2017-12-27 Debdeep Pati , Anirban Bhattacharya , Yun Yang

We review the recent generalized fractional calculus of variations. We consider variational problems containing generalized fractional integrals and derivatives and study them using indirect methods. In particular, we provide necessary…

Optimization and Control · Mathematics 2014-05-13 Tatiana Odzijewicz , Delfim F. M. Torres

In this paper we obtain an explicit formula of the parameter dependence of the partial derivatives of the Green's functions related to two-point boundary conditions. Such expression follows as an integral of both kernels times the…

Classical Analysis and ODEs · Mathematics 2024-05-28 Alberto Cabada , Lucía López-Somoza

We investigate the existence of nontrivial solutions of parameter-dependent elliptic equations with deviated argument in annular-like domains in $\mathbb{R}^{n}$, with $n\geq 2$, subject to functional boundary conditions. In particular we…

Analysis of PDEs · Mathematics 2025-01-09 Alessandro Calamai , Gennaro Infante

Individuals may differ in their parameter values. This article discusses a three-step method of studying such differences by calculating and then modeling "individual parameter contributions", making the study of heterogeneity in arbitrary…

Methodology · Statistics 2013-04-15 Daniel Leonard Oberski

The aim of this paper is to study certain problems of calculus of variations, that are dependent upon a Lagrange function on a Caputo-type fractional derivative. This type of fractional operator is a generalization of the Caputo and the…

Optimization and Control · Mathematics 2016-02-24 Ricardo Almeida

In this article we study a coupled system of differential equations with Allen-Cahn type non-linearity. Motivated by physical phenomena one of the unknowns in the system is accompanied by a singular perturbation parameter ${\epsilon}^2$ .…

Analysis of PDEs · Mathematics 2024-10-23 Javier Monreal , Michał Kowalczyk

We consider the bifurcation problem $u'' + \lambda u = N(u)$ with two point boundary conditions where $N(u)$ is a general nonlinear term which may also depend on the eigenvalue $\lambda$. We give a variational characterization of the…

patt-sol · Physics 2009-10-30 R. D. Benguria , M. C. Depassier

We investigate continuous parameter dependence for solutions of general boundary value problems for ordinary linear differential systems. The generalization of Kiguradze's theorem (1987) on correctness of such problems was obtained. Also…

Analysis of PDEs · Mathematics 2011-06-22 Tanya Kodliuk , Vladimir Mikhailets , Nadya Reva

A Dirichlet-type problem is studied for an equation of even order with variable coefficients. A criterion for the uniqueness of a solution is given. The solution is built in the form of a Fourier series. When justifying the convergence of…

Analysis of PDEs · Mathematics 2021-06-01 B. Irgashev

We develop a functional model for operators arising in the study of boundary-value problems of materials science and mathematical physics. We then provide explicit formulae for the resolvents of the associated extensions of symmetric…

Analysis of PDEs · Mathematics 2022-05-10 Kirill D. Cherednichenko , Alexander V. Kiselev , Luis O. Silva

This work studies the parameter-dependent diffusion equation in a two-dimensional domain consisting of locally mirror symmetric layers. It is assumed that the diffusion coefficient is a constant in each layer. The goal is to find…

Numerical Analysis · Mathematics 2024-12-20 Antti Autio , Antti Hannukainen

Ordinary differential equations are widely-used in the field of systems biology and chemical engineering to model chemical reaction networks. Numerous techniques have been developed to estimate parameters like rate constants, initial…

Molecular Networks · Quantitative Biology 2012-07-06 Daniel Kaschek , Jens Timmer

An overview of existing nonparametric tests of extreme-value dependence is presented. Given an i.i.d.\ sample of random vectors from a continuous distribution, such tests aim at assessing whether the underlying unknown copula is of the {\em…

Methodology · Statistics 2014-10-27 Axel Bücher , Ivan Kojadinovic

A variational approach is employed to find stationary solutions to a free boundary problem modeling an idealized electrostatically actuated MEMS device made of an elastic plate coated with a thin dielectric film and suspended above a rigid…

Analysis of PDEs · Mathematics 2014-09-10 Philippe Laurencot , Christoph Walker

We obtain necessary optimality conditions for variational problems with a Lagrangian depending on a Caputo fractional derivative, a fractional and an indefinite integral. Main results give fractional Euler-Lagrange type equations and…

Optimization and Control · Mathematics 2011-11-11 Ricardo Almeida , Shakoor Pooseh , Delfim F. M. Torres

Solutions of boundary value problems for a diffusion equation of fractional and variable order in differential and difference settings are studied. It is shown that the method of energy inequalities is applicable to obtaining a priori…

Numerical Analysis · Mathematics 2012-11-22 A. A. Alikhanov

In this paper, we study weakly nonlinear boundary value problems on infinite intervals. For such problems, we provide criteria for the existence of solutions as well as a qualitative description of the behavior of solutions depending on a…

Classical Analysis and ODEs · Mathematics 2020-02-03 Benjamin Freedman , Jesus Rodriguez

This paper investigates the existence of positive solutions of a singular boundary value problem with negative exponent similar to standard Emden--Fowler equation. A necessary and sufficient condition for the existence of $C[0,1]$ positive…

Classical Analysis and ODEs · Mathematics 2007-05-23 Yuxia Wang , Xiyu Liu