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Extracting and detecting spike activities from the fluorescence observations is an important step in understanding how neuron systems work. The main challenge lies in that the combination of the ambient noise with dynamic baseline…

Neurons and Cognition · Quantitative Biology 2019-02-01 Zhuangkun Wei , Bin Li , Weisi Guo , Wenxiu Hu , Chenglin Zhao

A Bragg waveguide-based resonant fluidic sensor operating in THz band is studied. A fused deposition modeling 3D printing technique is employed to fabricate the sensor where the liquid analyte is flowing in the microfluidic channel…

The applications of Fluorescence resonance energy transfer (FRET) have expanded tremendously in the last 25 years, and the technique has become a staple technique in many biological and biophysical fields. FRET can be used as spectroscopic…

Using the measurements collected at a number of known locations by a moving binary sensor, characterised by an unknown threshold, the problem is to estimate the parameters of a biochemical source, continuously releasing material into the…

Applications · Statistics 2016-08-24 Branko Ristic , Ajith Gunatilaka , Ralph Gailis

We investigate the propagation of random fluctuations through biochemical networks in which the concentrations of species are large enough so that the unperturbed problem is well-described by ordinary differential equation. We characterize…

Probability · Mathematics 2007-05-23 David Anderson , Jonathan Mattingly , H. Frederik Nijhout , Michael Reed

Speckle patterns produced by disordered scattering systems exhibit a sensitivity to addition of individual particles which can be used for sensing applications. Using a coupled dipole model we investigate how multiple scattering can enhance…

Optics · Physics 2021-08-03 Joel Berk , Matthew R. Foreman

Rapid detection of bacterial growth is crucial in clinical, food safety, and environmental contexts, yet conventional optical methods are limited by noise and require hours of incubation. Here, we present the first experimental…

We show that, in optical pump-probe experiments on bulk samples, the statistical distribution of the intensity of ultrashort light pulses after the interaction with a nonequilibrium complex material can be used to measure the time-dependent…

Strongly Correlated Electrons · Physics 2017-11-08 Francesco Randi , Martina Esposito , Francesca Giusti , Fulvio Parmigiani , Oleg Misochko , Daniele Fausti , Martin Eckstein

We experimentally and numerically study the potential of photoacoustic-guiding for light focusing through scattering samples via wavefront-shaping and iterative optimization. We experimentally demonstrate that the focusing efficiency on an…

Detection and location of moving prey utilizing electrosense or mechanosense is a strategy commonly followed by animals which cannot rely on visual sense or hearing. In this article we consider the possibility to detect the source of a…

Biological Physics · Physics 2009-11-07 Bjoern Naundorf , Jan A. Freund

Monolayer semiconductors hold great potential for nanoscale electronics, optoelectronics, and photonics. Excitons dominate their optical properties. As their electric fields extend outside the monolayer, they are sensitive to their…

We describe the effect of optical aberrations on fluorescence fluctuations microscopy (FFM), when focusing through a single living cell. FFM measurements are performed in an aqueous fluorescent solution and prove to be a highly sensitive…

Biological Physics · Physics 2014-03-13 Charles-Edouard Leroux , Alexei Grichine , Irène Wang , Antoine Delon

We consider the limiting behavior of fluctuations of small noise diffusions with multiple scales around their homogenized deterministic limit. We allow full dependence of the coefficients on the slow and fast motion. These processes arise…

Probability · Mathematics 2015-02-20 Konstantinos Spiliopoulos

Even at zero temperature, there exist phase fluctuations associated with an array of Bose-Einstein condensates confined in a one-dimensional optical lattice. We demonstrate a method to measure the phase fluctuations based on the Fourier…

Quantum Gases · Physics 2015-06-11 Bing Wang , Qiang Zhu , Hailong Zhou , Dezhi Xiong , Hongwei Xiong , Baolong Lu

We have implemented a multi-functional optofluidic sensor that can monitor changes in the refractive index and pressure of biofluid simultaneously and can detect free-solution molecular interaction in-situ. In this paper, we demonstrate two…

Optics · Physics 2014-10-16 Zhida Xu , Logan Liu

In this paper, we propose and evaluate a novel algorithm for performing spectrum sensing on linear modulations based on second-order cyclic features of the received signals. The proposed approach has similar computational complexity to that…

Signal Processing · Electrical Eng. & Systems 2020-02-11 Anantha K. Karthik , Jameer Ali M. S , Mohammed Zafar Ali Khan , A. Bhagavathi Rao

FRET measurements can provide dynamic spatial information on length scales smaller than the diffraction limit of light. Several methods exist to measure FRET between fluorophores, including Fluorescence Lifetime Imaging Microscopy (FLIM),…

Quantitative Methods · Quantitative Biology 2017-01-09 Bryan Kaye , Peter J. Foster , Tae Yeon Yoo , Daniel J. Needleman

Understanding under which conditions the increase of systems complexity is evolutionary advantageous, and how this trend is related to the modulation of the intrinsic noise, are fascinating issues of utmost importance for synthetic and…

Molecular Networks · Quantitative Biology 2018-08-01 Fabrizio Pucci , Marianne Rooman

Amperometry is a commonly used electrochemical method for studying the process of exocytosis in real-time. Given the high precision of recording that amperometry procedures offer, the volume of data generated can span over several hundreds…

Subcellular Processes · Quantitative Biology 2023-02-07 Jeyashree Krishnan , Zeyu Lian , Pieter E. Oomen , Xiulan He , Soodabeh Majdi , Andreas Schuppert , Andrew Ewing

Ultrasensitive detections have been proposed as an application of optomechanical systems. Here we develop an approach to mass sensing by comparing the detected quadratures of light field coupled to a mechanical resonator, whose slight…

Quantum Physics · Physics 2017-10-10 Qing Lin , Bing He , Min Xiao