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Mathematical models of stem cell differentiation are commonly based upon the concept of subsequent cell fate decisions, each controlled by a gene regulatory network. These networks exhibit a multistable behavior and cause the system to…

Quantitative Methods · Quantitative Biology 2011-07-06 Christian Breindl , Daniella Schittler , Steffen Waldherr , Frank Allgöwer

The event-triggered control with intermittent output can reduce the communication burden between the controller and plant side over the network. It has been exploited for adaptive output feedback control of uncertain nonlinear systems in…

Systems and Control · Electrical Eng. & Systems 2026-03-26 Gewei Zuo , Lijun Zhu

In this article we develop a highly integrated effective degree approach to modeling epidemic and awareness spreading processes on multiplex networks coupled with awareness-dependent adaptive rewiring. This approach keeps track of the…

Physics and Society · Physics 2021-04-05 Xiao-Long Peng , Yi-Dan Zhang

Network remodeling, or adaptation, in the presence of periodically driven forcings has hereto remained largely unexplored, despite the fact that a broad class of biological transport networks, e.g. animal vasculature, depends on periodic…

Adaptation and Self-Organizing Systems · Physics 2026-01-01 Purba Chatterjee , Eleni Katifori

We study the spread of a novel state in a network, in the presence of an exogenous control. The considered controlled evolutionary dynamics is a non-homogeneous Markov process that describes the evolution of the states of all nodes in the…

Systems and Control · Electrical Eng. & Systems 2020-06-23 Lorenzo Zino , Giacomo Como , Fabio Fagnani

Here we provide a detailed analysis, along with some extensions and additonal investigations, of a recently proposed self-organised model for the evolution of complex networks. Vertices of the network are characterised by a fitness variable…

Physics and Society · Physics 2008-08-29 Guido Caldarelli , Andrea Capocci , Diego Garlaschelli

Adaptive network dynamical systems describe the co-evolution of dynamical quantities on the nodes as well as dynamics of the network connections themselves. For dense networks of many nodes, the resulting dynamics are typically…

Adaptation and Self-Organizing Systems · Physics 2025-09-18 Erik Andreas Martens , Christian Bick

Transport networks are crucial to the functioning of natural and technological systems. Nature features transport networks that are adaptive over a vast range of parameters, thus providing an impressive level of robustness in supply.…

Adaptation and Self-Organizing Systems · Physics 2017-11-28 Erik Andreas Martens , Konstantin Klemm

Cellular regulatory dynamics is driven by large and intricate networks of interactions at the molecular scale, whose sheer size obfuscates understanding. In light of limited experimental data, many parameters of such dynamics are unknown,…

Quantitative Methods · Quantitative Biology 2014-04-30 Bryan C. Daniels , Ilya Nemenman

Empirical estimation of critical points at which complex systems abruptly flip from one state to another is among the remaining challenges in network science. However, due to the stochastic nature of critical transitions it is widely…

Social and Information Networks · Computer Science 2014-07-09 B. Podobnik , T. Lipic , D. Horvatic , A. Majdandzic , S. Bishop , H. E. Stanley

We consider the problem of adaptive stabilization for discrete-time, multi-dimensional linear systems with bounded control input constraints and unbounded stochastic disturbances, where the parameters of the true system are unknown. To…

Systems and Control · Electrical Eng. & Systems 2023-04-04 Seth Siriya , Jingge Zhu , Dragan Nešić , Ye Pu

We investigate the dynamics of two models of biological networks with purely suppressive interactions between the units; species interacting via niche competition and neurons via inhibitory synaptic coupling. In both of these cases,…

Disordered Systems and Neural Networks · Physics 2015-08-12 David A. Kessler , Herbert Levine

The criticality hypothesis posits that biological neural networks operate near a phase transition, yet within standard Gaussian mean-field theories this regime appears fragile and requires fine tuning. Here we show that heavy-tailed…

Biological Physics · Physics 2026-03-20 Ryota Kojima

Adaptive networks change their connectivity with time, depending on their dynamical state. While synchronization in structurally static networks has been studied extensively, this problem is much more challenging for adaptive networks. In…

Adaptation and Self-Organizing Systems · Physics 2021-01-20 Rico Berner , Simon Vock , Eckehard Schöll , Serhiy Yanchuk

We present a systematic mathematical analysis of the qualitative steady-state response to rate perturbations in large classes of reaction networks. This includes multimolecular reactions and allows for catalysis, enzymatic reactions,…

Dynamical Systems · Mathematics 2017-11-22 Bernhard Brehm , Bernold Fiedler

Dynamical phase transitions (DPTs) characterize critical changes in system behavior occurring at finite times, providing a lens to study nonequilibrium phenomena beyond conventional equilibrium physics. While extensively studied in quantum…

Physics and Society · Physics 2024-12-10 Jiazhen Liu , Nathaniel M. Aden , Debasish Sarker , Chaoming Song

We investigate dynamics of a kinetic model of inhibitory autoregulation as exemplified when a protein inhibits its own production by interfering with its messenger RNA, known in molecular biology as translational autoregulation. We first…

Molecular Networks · Quantitative Biology 2019-01-09 Vivian Tyng , Michael E. Kellman

Continuous adaptation allows survival in an ever-changing world. Adjustments in the synaptic coupling strength between neurons are essential for this capability, setting us apart from simpler, hard-wired organisms. How these changes can be…

Neurons and Cognition · Quantitative Biology 2021-01-06 Jakob Jordan , Maximilian Schmidt , Walter Senn , Mihai A. Petrovici

The stability of complex networks, from power grids to biological systems, is crucial for their proper functioning. It is thus important to control such systems to maintain or restore their stability. Traditional approaches rely on…

Optimization and Control · Mathematics 2025-09-23 Yuzhen Qin , Fabio Pasqualetti , Danielle S. Bassett , Marcel van Gerven

Phase transitions in equilibrium and nonequilibrium systems play a major role in the natural sciences. In dynamical networks, phase transitions organize qualitative changes in the collective behavior of coupled dynamical units. Adaptive…

Adaptation and Self-Organizing Systems · Physics 2023-02-22 Jan Fialkowski , Serhiy Yanchuk , Igor M. Sokolov , Eckehard Schöll , Georg A. Gottwald , Rico Berner
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