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Convolution is a central operation in Convolutional Neural Networks (CNNs), which applies a kernel to overlapping regions shifted across the image. However, because of the strong correlations in real-world image data, convolutional kernels…

Kalman filtering can provide an optimal estimation of the system state from noisy observation data. This algorithm's performance depends on the accuracy of system modeling and noise statistical characteristics, which are usually challenging…

Systems and Control · Electrical Eng. & Systems 2025-04-18 Xun Xiao , Junbo Tie , Jinyue Zhao , Ziqi Wang , Yuan Li , Qiang Dou , Lei Wang

We present a structured matrix factorization approach to analyzing calcium imaging recordings of large neuronal ensembles. Our goal is to simultaneously identify the locations of the neurons, demix spatially overlapping components, and…

Neurons and Cognition · Quantitative Biology 2014-09-11 Eftychios A. Pnevmatikakis , Yuanjun Gao , Daniel Soudry , David Pfau , Clay Lacefield , Kira Poskanzer , Randy Bruno , Rafael Yuste , Liam Paninski

Humans and other animals behave as if we perform fast Bayesian inference underlying decisions and movement control given uncertain sense data. Here we show that a biophysically realistic model of the subthreshold membrane potential of a…

Neurons and Cognition · Quantitative Biology 2014-06-20 Michael G. Paulin , Andre van Schaik

Neurons encode information about the environment through their activity. As animals explore the environment, neurons rapidly acquire selectivity for distinct features of the external world; characterizing how these selectivity patterns…

Calcium imaging has become a fundamental neural imaging technique, aiming to recover the individual activity of hundreds of neurons in a cortical region. Current methods (mostly matrix factorization) are aimed at detecting neurons in the…

Applications · Statistics 2019-02-11 Gal Mishne , Adam S. Charles

We present results related to the performance of an algorithm for community detection which incorporates event-driven computation. We define a mapping which takes a graph G to a system of spiking neurons. Using a fully connected spiking…

Neural and Evolutionary Computing · Computer Science 2017-11-21 Kathleen E. Hamilton , Neena Imam , Travis S. Humble

We present results of a deep photonic spiking convolutional neural network, based on two-section VCSELs, targeting image classification. Training is based on unsupervised spike-timing dependent plasticity, whereas neuron time-multiplexing…

Neurons and Cognition · Quantitative Biology 2021-03-30 Menelaos Skontranis , George Sarantoglou , Stavros Deligiannidis , Adonis Bogris , Charis Mesaritakis

Calcium imaging has become a powerful and popular technique to monitor the activity of large populations of neurons in vivo. However, for ethical considerations and despite recent technical developments, recordings are still constrained to…

Neurons and Cognition · Quantitative Biology 2023-02-07 Bryan M. Li , Theoklitos Amvrosiadis , Nathalie Rochefort , Arno Onken

Graph Convolutional Networks (GCNs) achieve an impressive performance due to the remarkable representation ability in learning the graph information. However, GCNs, when implemented on a deep network, require expensive computation power,…

Machine Learning · Computer Science 2022-08-03 Zulun Zhu , Jiaying Peng , Jintang Li , Liang Chen , Qi Yu , Siqiang Luo

A systematic assessment of global neural network connectivity through direct electrophysiological assays has remained technically unfeasible even in dissociated neuronal cultures. We introduce an improved algorithmic approach based on…

Neurons and Cognition · Quantitative Biology 2015-06-03 Olav Stetter , Demian Battaglia , Jordi Soriano , Theo Geisel

Quantification of neuronal correlations in neuron populations helps us to understand neural coding rules. Such quantification could also reveal how neurons encode information in normal and disease conditions like Alzheimer's and…

Neurons and Cognition · Quantitative Biology 2021-05-10 Sathish Ande , Srinivas Avasarala , Ajith Karunarathne , Lopamudra Giri , Soumya Jana

Flow-Imaging Microscopy (FIM) is commonly used in both academia and industry to characterize subvisible particles (those $\le 25 \mu m$ in size) in protein therapeutics. Pharmaceutical companies are required to record vast volumes of FIM…

Quantitative Methods · Quantitative Biology 2017-09-04 Christopher P. Calderon , Austin L. Daniels , Theodore W. Randolph

Neurons in the central nervous system communicate with each other with the help of series of Action Potentials, or spike trains. Various studies have shown that neurons encode information in different features of spike trains, such as the…

Neurons and Cognition · Quantitative Biology 2014-10-21 Shubhanshu Shekhar , Kaushik Majumdar

Fluorescence Microcopy Calcium Imaging is a fundamental tool to in-vivo record and analyze large scale neuronal activities simultaneously at a single cell resolution. Automatic and precise detection of behaviorally relevant neuron activity…

Computer Vision and Pattern Recognition · Computer Science 2025-12-23 Ran Li , Pan Xiao , Kaushik Dutta , Youdong Guo

Spiking neural networks (SNN) hold the promise of being a more biologically plausible, low-energy alternative to conventional artificial neural networks. Their time-variant nature makes them particularly suitable for processing…

Machine Learning · Computer Science 2025-04-10 Jan Debus , Charlotte Debus , Günther Dissertori , Markus Götz

Blind deconvolution is an ill-posed problem arising in various fields ranging from microscopy to astronomy. The ill-posed nature of the problem requires adequate priors to arrive to a desirable solution. Recently, it has been shown that…

Computer Vision and Pattern Recognition · Computer Science 2021-12-21 Gustav Bredell , Ertunc Erdil , Bruno Weber , Ender Konukoglu

Convolutional neural networks (CNNs) define the current state-of-the-art for image recognition. With their emerging popularity, especially for critical applications like medical image analysis or self-driving cars, confirmability is…

Computer Vision and Pattern Recognition · Computer Science 2018-01-08 Keyang Zhou , Bernhard Kainz

This paper reports on the use of a convolutional neural network (CNN) methodology to analyse fluorescence images of calcium-ion Coulomb crystals in the gas phase. A transfer-learning approach is adopted using the publicly available RESNET50…

Restoring naturalistic finger control in assistive technologies requires the continuous decoding of motor intent with high accuracy, efficiency, and robustness. Here, we present a spike-based decoding framework that integrates spiking…

Human-Computer Interaction · Computer Science 2025-09-05 Farah Baracat , Agnese Grison , Dario Farina , Giacomo Indiveri , Elisa Donati