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We investigate the translocation of a stiff polymer through a nanopore in a membrane, in the presence of binding particles (chaperones) that bind reversibly to the polymer on both sides of the membrane. A bound chaperone covers one…

Statistical Mechanics · Physics 2016-08-16 Tobias Ambjörnsson , Ralf Metzler

One of the major theoretical methods in understanding polymer translocation through a nanopore is the Fokker-Planck formalism based on the assumption of quasi-equilibrium of polymer conformations. The criterion for applicability of the…

Soft Condensed Matter · Physics 2018-02-14 Harshwardhan H. Katkar , Murugappan Muthukumar

We investigate the voltage-driven translocation of an inhomogeneously charged polymer through a nanopore by utilizing discrete and continuous stochastic models. As a simplified illustration of the effect of charge distribution on…

Soft Condensed Matter · Physics 2009-11-13 Aruna Mohan , Anatoly B. Kolomeisky , Matteo Pasquali

Polymer translocation in crowded environments is a ubiquitous phenomenon in biological systems. We studied polymer translocation through a pore in free, one-sided (asymmetric), and two-sided (symmetric) crowded environments. Extensive…

Soft Condensed Matter · Physics 2024-03-01 Vrinda Garg , Rejoy Mathew , Riyan Ibrahim , Kulveer Singh , Surya K. Ghosh

We study the translocation of a semiflexible polymer through a conical channel with attractive surface interactions and a driving force which varies spatially inside the channel. Using the results of the translocation dynamics of a flexible…

Soft Condensed Matter · Physics 2022-11-15 Andri Sharma , Rajeev Kapri , Abhishek Chaudhuri

This paper reports the force spectroscopy analysis of a polymer that translocates from one side of a membrane to the other side through an extended pore, pulled by a cantilever that moves with constant velocity against the damping and the…

Soft Condensed Matter · Physics 2018-12-12 Alessandro Fiasconaro , Fernando Falo

We investigate the translocation of a stiff polymer consisting of M monomers through a nanopore in a membrane, in the presence of binding particles (chaperones) that bind onto the polymer, and partially prevent backsliding of the polymer…

Biomolecules · Quantitative Biology 2015-06-26 T. Ambjoernsson , M. A. Lomholt , R. Metzler

We consider single particle and polymer translocation where the frictional properties experienced from the environment are changing in time. This work is motivated by the interesting frequency responsive behaviour observed when a polymer is…

Soft Condensed Matter · Physics 2012-12-06 Jack A. Cohen , Abhishek Chaudhuri , Ramin Golestanian

We present a numerical study of forced polymer translocation by using two separate pore models. Both of them have been extensively used in previous forced translocation studies. We show that variations in the pore model affect the forced…

Biological Physics · Physics 2015-05-19 V. V. Lehtola , K. Kaski , R. P. Linna

We consider the flow-driven translocation of single polymer chains through nanochannels. Using analytical calculations based on the de Gennes blob model and mesoscopic numerical simulations, we estimate the threshold flux for the…

Soft Condensed Matter · Physics 2011-10-26 Rodrigo Ledesma-Aguilar , Takahiro Sakaue , Julia M. Yeomans

Polymer ejection from nano-confinement has been of interest due to its relation to various fundamental sciences and applications. However, the ejection dynamics of a polymer with different persistence lengths from confinement through a…

Soft Condensed Matter · Physics 2023-06-13 Farzaneh Moazemi , Samaneh Ghanbari-Kashan , Narges Nikoofard

Langevin dynamics simulations are performed to investigate ejection dynamics of spherically confined flexible polymers through a pore. By varying the chain length $N$ and the initial volume fraction $\phi_0$ of the monomers, two scaling…

Soft Condensed Matter · Physics 2020-01-29 Hao-Chun Huang , Pai-Yi Hsiao

We have used Langevin dynamics to simulate the forced translocation of linked polymer rings through a narrow pore. For fixed size (i.e. fixed number of monomers) the translocation time depends on the link type and on whether the rings are…

Statistical Mechanics · Physics 2020-06-24 Michele Caraglio , Enzo Orlandini , Stuart G Whittington

We investigate the dynamics of DNA translocation through a nanopore driven by an external force using Langevin dynamics simulations in two dimensions (2D) to study how the translocation dynamics depend on the details of the DNA sequences.…

Soft Condensed Matter · Physics 2008-12-09 Kaifu Luo , Tapio Ala-Nissila , See-Chen Ying , Aniket Bhattacharya

We study the passage (translocation) of a self-avoiding polymer through a membrane pore in two dimensions. In particular, we numerically measure the probability distribution Q(T) of the translocation time T, and the distribution P(s,t) of…

Statistical Mechanics · Physics 2009-02-12 Clément Chatelain , Yacov Kantor , Mehran Kardar

Adsorption of polymers to surfaces is crucial for understanding many fundamental processes in nature. Recent experimental studies indicate that the adsorption dynamics is dominated by non-equilibrium effects. We investigate the adsorption…

Soft Condensed Matter · Physics 2009-05-12 Debabrata Panja , Gerard T. Barkema , Anatoly B. Kolomeisky

We consider the escape of a flexible, self-avoiding polymer chain out of a confined geometry. By means of simulations, we demonstrate that the translocation time can be described by a simple scaling law that exhibits a nonlinear dependence…

Soft Condensed Matter · Physics 2009-11-11 Angelo Cacciuto , Erik Luijten

DNA capture with high fidelity is an essential part of nanopore translocation. We report several important aspects of the capture process and subsequent translocation of a model DNA polymer through a solid-state nanopore in presence of an…

Soft Condensed Matter · Physics 2022-07-06 Swarnadeep Seth , Aniket Bhattacharya

We propose a simple scaling theory describing the variation of the mean first passage time (MFPT) $\tau(N,M)$ of a regular block copolymer of chain length $N$ and block size $M$ which is dragged through a selective liquid-liquid interface…

Soft Condensed Matter · Physics 2009-11-11 A. Corsi , A. Milchev , V. G. Rostiashvili , T. A. Vilgis

We consider the influence of electrostatic forces on driven translocation dynamics of a flexible polyelectrolyte being pulled through a nanopore by an external force on the head monomer. To this end, we augment the iso-flux tension…

Soft Condensed Matter · Physics 2020-07-07 Jalal Sarabadani , Sahin Buyukdagli , Tapio Ala-Nissila
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