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Signalling pathways are abstractions that help life scientists structure the coordination of cellular activity. Cross-talk between pathways accounts for many of the complex behaviours exhibited by signalling pathways and is often critical…

Computational Engineering, Finance, and Science · Computer Science 2010-02-23 Robin Donaldson , Muffy Calder

Large language models (LLMs) and vision-language models (VLMs) have the potential to transform biological research by enabling autonomous experimentation. Yet, their application remains constrained by rigid protocol design, limited…

Robotics · Computer Science 2025-07-03 Yibo Qiu , Zan Huang , Zhiyu Wang , Handi Liu , Yiling Qiao , Yifeng Hu , Shu'ang Sun , Hangke Peng , Ronald X Xu , Mingzhai Sun

Natural language is expected to be a key medium for various human-machine interactions in the era of large language models. When it comes to the biochemistry field, a series of tasks around molecules (e.g., property prediction, molecule…

Computation and Language · Computer Science 2023-06-22 Zheni Zeng , Bangchen Yin , Shipeng Wang , Jiarui Liu , Cheng Yang , Haishen Yao , Xingzhi Sun , Maosong Sun , Guotong Xie , Zhiyuan Liu

Prompted models have demonstrated impressive few-shot learning abilities. Repeated interactions at test-time with a single model, or the composition of multiple models together, further expands capabilities. These compositions are…

Summary: The development of automated servers to predict the three-dimensional structure of proteins has seen much progress over the years. These servers make modeling simpler, but largely exclude users from the process. We present an…

Biomolecules · Quantitative Biology 2017-02-08 Rowan Hatherley , David K. Brown , Özlem Tastan Bishop

Recent progress in Spoken Language Modeling has shown that learning language directly from speech is feasible. Generating speech through a pipeline that operates at the text level typically loses nuances, intonations, and non-verbal…

Computation and Language · Computer Science 2024-10-31 Maxime Poli , Emmanuel Chemla , Emmanuel Dupoux

This paper presents an integrated framework that combines traditional network optimization models with large language models (LLMs) to deliver interactive, explainable, and role-aware decision support for supply chain planning. The proposed…

Artificial Intelligence · Computer Science 2025-09-01 Saravanan Venkatachalam

Auto-regulatory feedback loops are one of the most common network motifs. A wide variety of stochastic models have been constructed to understand how the fluctuations in protein numbers in these loops are influenced by the kinetic…

Subcellular Processes · Quantitative Biology 2020-04-22 James Holehouse , Zhixing Cao , Ramon Grima

A Stochastic Simulator (SS) is proposed, based on a semiclassical description of the radiation-matter interaction, to obtain an efficient description of the lasing transition for devices ranging from the nanolaser to the traditional…

Optics · Physics 2015-02-09 G. P. Puccioni , G. L. Lippi

Probabilistic programming is related to a compositional approach to stochastic modeling by switching from discrete to continuous time dynamics. In continuous time, an operator-algebra semantics is available in which processes proceeding in…

Artificial Intelligence · Computer Science 2012-12-05 Eric Mjolsness

Human language is one of the most expressive tools for conveying intent, yet most artificial or biological systems lack mechanisms to interpret or respond meaningfully to it. Bridging this gap could enable more natural forms of control over…

Artificial Intelligence · Computer Science 2025-09-16 Nam H. Le , Patrick Erickson , Yanbo Zhang , Michael Levin , Josh Bongard

Many intelligent user interfaces employ application and user models to determine the user's preferences, goals and likely future actions. Such models require application analysis, adaptation and expansion. Building and maintaining such…

Artificial Intelligence · Computer Science 2013-01-18 Peter J. Gorniak , David L. Poole

We study the interaction of the programming construct "new", which generates statically scoped names, with communication via messages on channels. This interaction is crucial in security protocols, which are the main motivating examples for…

Cryptography and Security · Computer Science 2017-07-31 Martín Abadi , Bruno Blanchet , Cédric Fournet

A practical introduction to stochastic modelling of reaction-diffusion processes is presented. No prior knowledge of stochastic simulations is assumed. The methods are explained using illustrative examples. The article starts with the…

Subcellular Processes · Quantitative Biology 2007-11-19 Radek Erban , Jonathan Chapman , Philip Maini

Despite recent molecular technique improvements, biological knowledge remains incomplete. Reasoning on living systems hence implies to integrate heterogeneous and partial informations. Although current investigations successfully focus on…

Quantitative Methods · Quantitative Biology 2009-09-29 Jérémie Bourdon , Damien Eveillard , Samuel Gabillard , Theo Merle

We present Probabilistic Structure Integration (PSI), a system for learning richly controllable and flexibly promptable world models from data. PSI consists of a three-step cycle. The first step, Probabilistic prediction, involves building…

Multi-agent systems have been studied in various contexts of both application and theory. We take Dynamic Epistemic Logic (DEL), one of the formalisms designed to reason about such systems, as the foundation of the language we will build.…

Logic in Computer Science · Computer Science 2012-12-19 Anya Yermakova , Alexandru Baltag

We provide an overview of the emergence of large language models for scientific computing applications. We highlight use cases that involve natural language processing of scientific documents and specialized languages designed to describe…

Computation and Language · Computer Science 2024-06-12 Christopher Culver , Peter Hicks , Mihailo Milenkovic , Sanjif Shanmugavelu , Tobias Becker

Traditional psychological experiments utilizing naturalistic stimuli face challenges in manual annotation and ecological validity. To address this, we introduce a novel paradigm leveraging multimodal large language models (LLMs) as proxies…

Artificial Intelligence · Computer Science 2025-02-27 Xin Liu , Ziyue Zhang , Jingxin Nie

Dialogue systems is an increasingly popular task of natural language processing. However, the dialogue paths tend to be deterministic, restricted to the system rails, regardless of the given request or input text. Recent advances in program…

Computation and Language · Computer Science 2023-01-19 Eli Whitehouse , William Gerard , Yauhen Klimovich , Marc Franco-Salvador