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A relationship between the preexponent of the rate constant and the distribution over activation barrier energies for enzymatic/protein reactions is revealed. We consider an enzyme solution as an ensemble of individual molecules with…

Biomolecules · Quantitative Biology 2012-11-16 A. E. Sitnitsky

The paper is concerned with a class of mathematical models for polymeric fluids, which involves the coupling of the Navier-Stokes equations for a viscous, incompressible, constant-density fluid with a parabolic-hyperbolic…

Analysis of PDEs · Mathematics 2016-01-08 Miroslav Bulíček , Piotr Gwiazda , Endre Süli , Agnieszka Świerczewska-Gwiazda

Molecular isomerization kinetics in liquid solvents are determined by a complex interplay between the friction acting on a rotating dihedral due to interactions with the solvent, internal dissipation effects (also known as internal…

Chemical Physics · Physics 2023-09-15 Benjamin A. Dalton , Henrik Kiefer , Roland R. Netz

We consider a suspension of active rigid particles (swimmers) in a steady Stokes flow, where particles are distributed according to a stationary ergodic random process, and we study its homogenization in the macroscopic limit. A key point…

Analysis of PDEs · Mathematics 2023-03-15 Armand Bernou , Mitia Duerinckx , Antoine Gloria

A stochastic model for the dynamics of enzymatic catalysis in explicit, effective solvents under physiological conditions is presented. Analytically-computed first passage time densities of a diffusing particle in a spherical shell with…

Biomolecules · Quantitative Biology 2015-06-04 Jeremy Schofield , Paul Inder , Raymond Kapral

The celebrated Stokes Law (SL) of hydrodynamics predicts that the velocity of a particle pulled through a liquid by an external force, Fex, is directly proportional to the force and inversely proportional to the friction {\zeta} acted by…

Soft Condensed Matter · Physics 2024-02-27 Subhajit Acharya , Biman Bagchi

A mechanism for relationship of solvent viscosity with reaction rate constant at enzyme action is suggested. It is based on fluctuations of electric field in enzyme active site produced by thermally equilibrium rocking (cranckshaft motion)…

Biomolecules · Quantitative Biology 2009-11-13 A. E. Sitnitsky

Kinetically constrained models (KCMs) have gained much interest as models that assign the origins of interesting dynamic properties of supercooled liquids to dynamical facilitation mechanisms that have been revealed in many expreiments and…

Soft Condensed Matter · Physics 2015-10-22 Seo-Woo Choi , Soree Kim , YounJoon Jung

The description of molecular motion by macroscopic hydrodynamics has a long and continuing history. The Stokes-Einstein relation between the diffusion coefficient of a solute and the solvent viscosity predicted using macroscopic continuum…

Disordered Systems and Neural Networks · Physics 2007-05-23 Xiaoyu Xia , Peter G. Wolynes

The present article presents a molecular dynamics study of several anomalies of core-softened systems. It is well known that many core-softened liquids demonstrate diffusion anomaly. Usual intuition relates the diffusion coefficient to…

Soft Condensed Matter · Physics 2015-06-15 Yu. D. Fomin , V. N. Ryzhov

Combining direct computations with invariance arguments, Taylor's constitutive equation for an emulsion can be extrapolated to high shear rates. We show that the resulting expression is consistent with the rigorous limits of small drop…

Fluid Dynamics · Physics 2007-05-23 Klaus Kroy , Isabelle Capron , Madeleine Djabourov

This review is devoted to the large-scale rheology of suspensions of rigid particles in Stokes fluid. After describing recent results on the definition of the effective viscosity of such systems in the framework of homogenization theory, we…

Analysis of PDEs · Mathematics 2023-01-03 Mitia Duerinckx , Antoine Gloria

We investigate the existence of weak solutions to a multi-component system, consisting of compressible chemically reacting components, coupled with the compressible Stokes equation for the velocity. Specifically, we consider the case of…

Analysis of PDEs · Mathematics 2025-08-26 Piotr B. Mucha , Sarka Necasova , Maja Szlenk

Hooke's law states that the forces or stresses experienced by an elastic object are proportional to the applied deformations or strains. The number of coefficients of proportionality between stress and strain, i.e., the elastic moduli, is…

This paper first reviews the shoving model for the non-Arrhenius viscosity of viscous liquids. According to this model the main contribution to the activation energy of a flow event is the energy needed for molecules to shove aside the…

Soft Condensed Matter · Physics 2013-01-29 Jeppe C. Dyre , Tage Christensen , Niels Boye Olsen

A new microscopic formula for the viscosity of liquids and solids is derived rigorously from a first-principles (microscopically reversible) Hamiltonian for particle-bath atomistic motion. The derivation is done within the framework of…

Soft Condensed Matter · Physics 2024-04-17 Alessio Zaccone

Consider a colloidal suspension of rigid particles in a steady Stokes flow. In a celebrated work, Einstein argued that in the regime of dilute particles the system behaves at leading order like a Stokes fluid with some explicit effective…

Analysis of PDEs · Mathematics 2020-12-30 Mitia Duerinckx , Antoine Gloria

We discuss the shear viscosity of a Newtonian solution of catalytic enzymes and substrate molecules. The enzyme is modeled as a two-state dimer consisting of two spherical domains connected with an elastic spring. The enzymatic…

Soft Condensed Matter · Physics 2020-01-30 Yuto Hosaka , Shigeyuki Komura , David Andelman

The aim of this paper is to present a modeling for the rheological behavior of simple liquids as a function of the amplitude of the imposed shear stress or strain. The elastic mode theory (Ref. 6) is first generalized to take into account…

Soft Condensed Matter · Physics 2023-02-14 Frédéric Aitken , Ferdinand Volino

Enzymes show two distinct transport behaviors in the presence of their substrates in solution. First, their diffusivity enhances with increasing substrate concentration. In addition, enzymes perform directional motion toward regions with…

Biological Physics · Physics 2018-11-06 Farzad Mohajerani , Xi Zhao , Ambika Somasundar , Darrell Velegol , Ayusman Sen
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