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Magnetic resonance imaging (MRI) revolutionized diagnostic medicine and biomedical research by allowing a noninvasive access to spin ensembles. To enhance MRI resolution to the nanometer scale, new approaches including scanning probe…

Mesoscale and Nanoscale Physics · Physics 2019-10-23 Philip Willke , Kai Yang , Yujeong Bae , Andreas J. Heinrich , Christopher P. Lutz

Optically-pumped magnetic gradiometers (OPGs) play a crucial role in applications such as magnetic anomaly detection and bio-magnetic measurements. This study classifies current OPGs into four types based on their differential modes:…

Optics · Physics 2026-05-05 Hangfei Ye , Chenlu Xu , Min Hu , Haifeng Dong

Nuclear magnetic resonance (NMR) spectroscopy is a widely used tool for chemical analysis and molecular structure identification. Because it typically relies on the weak magnetic fields produced by a small thermal nuclear spin polarization,…

Applied Physics · Physics 2020-06-11 Dominik B. Bucher , David R. Glenn , Hongkun Park , Mikhail D. Lukin , Ronald L. Walsworth

We demonstrated optically detected magnetic resonance (ODMR) of nitrogen-vacancy (NV) centers in microdiamonds inside a diamond anvil cell pressurized with nanopolycrystalline diamond (NPD) anvils. NPD exhibits high optical transparency,…

Materials Science · Physics 2026-02-24 Masahiro Ohkuma , Keigo Arai , Kenji Ohta , Toru Shinmei , Ryo Matsumoto , Yoshihiko Takano , Tetsuo Irifune

Point defects in solids promise precise measurements of various quantities. Especially magnetic field sensing using the spin of point defects has been of great interest recently. When optical readout of spin states is used, point defects…

Atomic-scale magnetic field sensors based on nitrogen vacancy (NV) defects in diamonds are an exciting platform for nanoscale nuclear magnetic resonance (NMR) spectroscopy. The detection of NMR signals from a few zeptoliters to single…

Optically pumped magnetometers (OPMs) have emerged as a powerful technique for high-resolution magnetic field imaging. However, achieving sub-millimeter spatial resolution at sub-picotesla sensitivities ($\mathrm{< 1\,pT/\sqrt{Hz}}$)…

Single-spin magnetic resonance spectroscopy promises to yield structural and chemical information at the level of individual atoms or molecules, in a non-invasive way. Here, we use an Er3+ paramagnetic center in a CaWO4 crystal, detected by…

Magnetic field sensing is essential for applications in communication, environmental monitoring, and biomedical diagnostics. Quantum sensors based on solid-state spin defects, such as nitrogen-vacancy centers in diamond or boron vacancies…

Nitrogen-vacancy (NV) centers in diamond have emerged as quantum sensors capable of detecting nuclear magnetic resonance (NMR) signals at unprecedented length scales, ranging from picoliter sample volumes down to single spins at the diamond…

Chemical Physics · Physics 2025-01-07 Nick R. von Grafenstein , Karl D. Briegel , Jorge Casanova , Dominik B. Bucher

We present a scheme of surface-sensitive nuclear magnetic resonance in optically pumped semiconductors, where an NMR signal from a part of the surface of a bulk compound semiconductor is detected apart from the bulk signal. It utilizes…

Mesoscale and Nanoscale Physics · Physics 2008-09-12 Atsushi Goto , Tadashi Shimizu , Kenjiro Hashi , Shinobu Ohki

Nuclear magnetic resonance (NMR) is a powerful method for determining the structure of molecules and proteins. While conventional NMR requires averaging over large ensembles, recent progress with single-spin quantum sensors has created the…

Over recent decades, the value of conducting experiments at lower frequencies and in inhomogeneous and/or time-variable fields has grown. For example, an interest in the nanoscale heterogeneities of hydration dynamics demands increasingly…

Chemical Physics · Physics 2022-11-23 Alec A. Beaton , Alexandria Guinness , John M. Franck

The relationship between paramagnetic defect centers and UV absorption bands simultaneously generated by ionizing radiation in Ge-doped SiO2 glass is investigated using magneto-optical techniques. A sample of 7.0 mol% Ge-doped SiO2 was…

Materials Science · Physics 2007-05-23 D. Poulios , N. P. Bigelow , J. P. Spoonhower

Cardiovascular MRI (CMR) is a non-invasive imaging modality that provides excellent soft-tissue contrast without the use of ionizing radiation. Physiological motions and limited speed of MRI data acquisition necessitate development of…

Image and Video Processing · Electrical Eng. & Systems 2020-08-13 Chong Chen , Yingmin Liu , Philip Schniter , Matthew Tong , Karolina Zareba , Orlando Simonetti , Lee Potter , Rizwan Ahmad

Magnetic resonance imaging (MRI) is a powerful technique for investigating the microscopic properties and dynamics of physical systems. In this work we demonstrate state-sensitive MRI of ultracold atoms in an optical lattice. Single-shot…

Single-cell analysis can unravel functional heterogeneity within cell populations otherwise obscured by ensemble measurements. However, non-invasive techniques that probe chemical entities and their dynamics are still lacking. This…

Applied Physics · Physics 2023-06-14 Nick Ruben Neuling , Robin Derek Allert , Dominik Benjamin Bucher

Nuclear magnetic resonance (NMR) at the single-molecule level with atomic resolution holds transformative potential for structural biology and surface chemistry. Near-surface solid-state spin sensors with optical readout ability offer a…

Quantum Physics · Physics 2025-12-12 Yu Chen , Qi Zhang , Yuanhong Teng , Chihang Luo , Zhijie Li , Jinpeng Liu , Ya Wang , Fazhan Shi , Jiangfeng Du

Nuclear magnetic resonance (NMR) spectroscopy is, in principle, a promising candidate to study the intracellular chemistry of single microscopic living entities. However, due to sensitivity limitations, NMR experiments were reported only on…

Biological Physics · Physics 2015-11-23 Marco Grisi , Beatrice Volpe , Roberto Guidetti , Nicola Harris , Giovanni Boero

Whether in fundamental physics, cybersecurity or finance, the detection of anomalies with machine learning techniques is a highly relevant and active field of research, as it potentially accelerates the discovery of novel physics or…