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Integrating optical diffraction tomography with imaging flow cytometry enables label-free quantifications of the three-dimensional (3D) morphology and hemoglobin content of red blood cells (RBCs) in their natural form. Self-rotation of RBCs…

Medical Physics · Physics 2023-09-28 Yu-Hsiang Chang , Yang-Hsien Lin , Kung-Bin Sung

The distribution of Red Blood Cells in a confined channel flow is inhomogeneous and shows a marked depletion near the walls due to a competition between migration away from the walls and shear-induced diffusion resulting from interactions…

Biological Physics · Physics 2015-06-15 Xavier Grandchamp , Gwennou Coupier , Aparna Srivastav , Christophe Minetti , Thomas Podgorski

Understanding how red blood cell (RBC) suspensions navigate porous materials is critical for for both fundamental physiology, such as maternal-fetal exchange in the placenta, and transformative biomedical applications, including rapid,…

Soft Condensed Matter · Physics 2025-09-03 Sampad Laha , Ananta Kumar Nayak , Alexander Farutin , Suman Chakraborty , Chaouqi Misbah

Via computer simulations, we provide evidence that the shear rate induced red blood cell tumbling-to-tank-treading transition also occurs at quite high volume fractions, where collective effects are important. The transition takes place as…

Soft Condensed Matter · Physics 2013-12-13 Timm Krüger , Markus Gross , Dierk Raabe , Fathollah Varnik

Biconcave-discoid (empirical shape of a red blood cell) capsule finds numerous applications in the field of bio-fluid dynamics and rheology, apart from understanding the behavior of red blood cells (RBC) in blood flow. A detailed analysis…

Soft Condensed Matter · Physics 2018-12-11 Sudip Das , Shivraj D. Deshmukh , Rochish M Thaokar

Computational Fluid Dynamics (CFD) is currently used to design and improve the hydraulic properties of biomedical devices, wherein the large scale blood circulation needs to be simulated by accounting for the mechanical response of red…

Fluid Dynamics · Physics 2024-12-24 F. Guglietta , M. Behr , L. Biferale , G. Falcucci , M. Sbragaglia

Mesoscopic numerical simulations provide a unique approach for the quantification of the chemical influences on red blood cell functionalities. The transport Dissipative Particles Dynamics (tDPD) method can lead to such effective multiscale…

Computational Physics · Physics 2017-06-07 Ansel L. Blumers , Yu-Hang Tang , Zhen Li , Xuejin Li , George E. Karniadakis

The manual evaluation, classification and counting of biological objects demands for an enormous expenditure of time and subjective human input may be a source of error. Investigating the shape of red blood cells (RBCs) in microcapillary…

Biological Physics · Physics 2018-06-22 Alexander Kihm , Lars Kaestner , Christian Wagner , Stephan Quint

Cell dynamics simulation is used to investigate the phase behavior of block copolymer/homopolymer mixture subjected to a steady shear flow. Phase transitions occur from transverse to parallel and then to perpendicular lamellar structure…

Soft Condensed Matter · Physics 2015-06-29 Y. Guo , J. Zhang , B. Wang , H. Wu , M. Sun , J. Pan

The dynamics and rheology of suspensions of fluid vesicles or red blood cells is investigated by a combination of molecular dynamics and mesoscale hydrodynamics simulations in two dimensions. The vesicle suspension is confined between two…

Soft Condensed Matter · Physics 2013-05-03 A. Lamura , G. Gompper

We study the rheology of a suspension of soft deformable droplets subjected to a pressure-driven flow. Through computer simulations, we measure the apparent viscosity as a function of droplet concentration and pressure gradient, and provide…

Soft Condensed Matter · Physics 2017-11-22 M. Foglino , A. N. Morozov , O. Henrich , D. Marenduzzo

A mixed suspension of red blood cells (RBCs) and microparticles flows through a cylindrical channel with a constriction mimicking a stenosed blood vessel. Our three-dimensional Lattice-Boltzmann simulations show that the RBCs are depleted…

Fluid Dynamics · Physics 2017-02-01 Christian Bächer , Lukas Schrack , Stephan Gekle

Cardiac disease and clinical intervention may both lead to an increased risk for thrombosis events due to modified blood flow in the heart, and thereby a change in the mechanical stimuli of blood cells passing through the chambers of the…

Microfluidic technologies are commonly used for the manipulation of red blood cell (RBC) suspensions and analyses of flow-mediated biomechanics. To enhance the performance of microfluidic devices, understanding the dynamics of the…

We present a numerical analysis of the lateral movement and equilibrium radial positions of red blood cells (RBCs) with major diameter of 8 $\mu$m under a Newtonian fluid in a circular channel with 50-$\mu$m diameter. Each RBC, modelled as…

In this paper, we present a spatio-temporal mathematical model for simulating the formation and growth of a thrombus. Blood is treated as a multi-constituent mixture comprised of a linear fluid phase and a thrombus (solid) phase. The…

The flow behavior of blood in microvessels is directly associated with tissue perfusion and oxygen delivery. Current efforts on modeling blood flow have primarily focused on the flow properties of blood with red blood cells (RBCs) having a…

Soft Condensed Matter · Physics 2024-06-03 Wei Chien , Gerhard Gompper , Dmitry A. Fedosov

The microvascular networks in the body of vertebrates consist of the smallest vessels such as arterioles, capillaries, and venules. The flow of RBCs through these networks ensures the gas exchange in as well as the transport of nutrients to…

Biological Physics · Physics 2021-02-26 A. Kihm , S. Quint , M. W. Laschke , M. D. Menger , T. John , L. Kaestner , C. Wagner

In this fluid dynamics video we show simulations of droplet breakup and collisions in simple shear flow. Due to the high resolution of the GPU-based simulations, we capture the transition from coalescence at low capillary numbers to sliding…

Fluid Dynamics · Physics 2012-10-16 Orest Shardt , Alexandra Komrakova , J. J. Derksen , Sushanta K. Mitra

Application of computation in many fields are growing fast in last two decades. Increasing on computation performance helps researchers to understand natural phenomena in many fields of science and technology including in life sciences.…

Biological Physics · Physics 2014-02-27 Suprijadi , Mohamad Rendi , Petrus Subekti , Sparisoma Viridi