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We present a simple and robust technique to extract kinetic rate models and thermodynamic quantities from single molecule time traces. SMACKS (Single Molecule Analysis of Complex Kinetic Sequences) is a maximum likelihood approach that…

Quantitative Methods · Quantitative Biology 2022-03-10 Sonja Schmid , Markus Götz , Thorsten Hugel

We describe a novel approach to statistical learning from particles tracked while moving in a random environment. The problem consists in inferring properties of the environment from recorded snapshots. We consider here the case of a fluid…

Information Theory · Computer Science 2008-06-09 Michael Chertkov , Lukas Kroc , Massimo Vergassola

Traffic forecasting represents a crucial problem within intelligent transportation systems. In recent research, Large Language Models (LLMs) have emerged as a promising method, but their intrinsic design, tailored primarily for sequential…

Machine Learning · Computer Science 2025-09-18 Hyotaek Jeon , Hyunwook Lee , Juwon Kim , Sungahn Ko

The process of diffusion is the most elementary stochastic transport process. Brownian motion, the representative model of diffusion, played a important role in the advancement of scientific fields such as physics, chemistry, biology and…

Statistical Mechanics · Physics 2015-08-11 Alexandre Bovet

Unlike equilibrium statistical mechanics, with its well-established foundations, a similar widely-accepted framework for non-equilibrium statistical mechanics (NESM) remains elusive. Here, we review some of the many recent activities on…

Statistical Mechanics · Physics 2015-05-30 T. Chou , K. Mallick , R. K. P. Zia

The evolution of the atomic structures of the combinatorial library of Sm-substituted thin film BiFeO3 along the phase transition boundary from the ferroelectric rhombohedral phase to the non-ferroelectric orthorhombic phase is explored…

Data Analysis, Statistics and Probability · Physics 2021-03-03 Chris Nelson , Anna N. Morozovska , Maxim A. Ziatdinov , Eugene A. Eliseev , Xiaohang Zhang , Ichiro Takeuchi , Sergei V. Kalinin

In this paper, we present a conceptually simple while empirically powerful framework for abstractive summarization, SimCLS, which can bridge the gap between the learning objective and evaluation metrics resulting from the currently…

Computation and Language · Computer Science 2021-06-04 Yixin Liu , Pengfei Liu

Simulating trajectories of multi-particle systems on complex energy landscapes is a central task in molecular dynamics (MD) and drug discovery, but remains challenging at scale due to computationally expensive and long simulations. Previous…

Machine Learning · Computer Science 2025-11-11 Sophia Tang , Yinuo Zhang , Pranam Chatterjee

We introduce a machine learning approach to determine the transition dynamics of silicon atoms on a single layer of carbon atoms, when stimulated by the electron beam of a scanning transmission electron microscope (STEM). Our method is…

Large language models (LLMs) leverage deep learning architectures to process and predict sequences of words, enabling them to perform a wide range of natural language processing tasks, such as translation, summarization, question answering,…

Computation and Language · Computer Science 2025-09-08 Mohammad Shahedur Rahman , Peng Gao , Yuede Ji

The cytoskeleton -- a collection of polymeric filaments, molecular motors, and crosslinkers -- is a foundational example of active matter, and in the cell assembles into organelles that guide basic biological functions. Simulation of…

Soft Condensed Matter · Physics 2022-06-13 Wen Yan , Saad Ansari , Adam Lamson , Matthew A. Glaser , Meredith Betterton , Michael J. Shelley

As CMOS nears the end of the projected scaling roadmap, significant effort has been devoted to the search for new materials and devices that can realize memory and logic. Spintronics, is one of the promising directions for the Post-CMOS…

Mesoscale and Nanoscale Physics · Physics 2016-11-18 Zoha Pajouhi , Swagath Venkataramani , Karthik Yogendra , Anand Raghunathan , Kaushik Roy

Operations research practitioners frequently want to model complicated functions that are are difficult to encode in their underlying optimisation framework. A common approach is to solve an approximate model, and to use a simulation to…

Optimization and Control · Mathematics 2022-07-06 Michael Forbes , Mitchell Harris , Marijn Jansen , Femke van der Schoot , Thomas Taimre

An efficient compositional framework is developed for simulation of CO2 storage in saline aquifers during a full-cycle injection, migration and post-migration processes. Essential trapping mechanisms, including structural, dissolution, and…

Fluid Dynamics · Physics 2023-01-20 Yuhang Wang , Ziliang Zhang , Cornelis Vuik , Hadi Hajibeygi

In this paper, we introduce a new heuristics for global optimization in scenarios where extensive evaluations of the cost function are expensive, inaccessible, or even prohibitive. The method, which we call Landscape-Sketch-and-Step (LSS),…

Machine Learning · Computer Science 2023-10-06 Rafael Monteiro , Kartik Sau

We provide a transmission line representation for channels exhibiting spin-momentum locking (SML) which can be used for both time-dependent and steady-state transport analysis on a wide variety of materials with spin-orbit coupling such as…

Mesoscale and Nanoscale Physics · Physics 2018-11-28 Shehrin Sayed , Seokmin Hong , Supriyo Datta

Building upon score-based learning, new interest in stochastic localization techniques has recently emerged. In these models, one seeks to noise a sample from the data distribution through a stochastic process, called observation process,…

Machine Learning · Statistics 2026-02-24 Louis Grenioux , Maxence Noble , Marylou Gabrié , Alain Oliviero Durmus

We propose the use of Flat Metric to assess the performance of reconstruction methods for single-molecule localization microscopy (SMLM) in scenarios where the ground-truth is available. Flat Metric is intimately related to the concept of…

Image and Video Processing · Electrical Eng. & Systems 2021-02-09 Quentin Denoyelle , Thanh-an Pham , Pol del Aguila Pla , Daniel Sage , Michael Unser

In this work, we use a tempering-based adaptive particle filter to infer from a partially observed stochastic rotating shallow water (SRSW) model which has been derived using the Stochastic Advection by Lie Transport (SALT) approach. The…

Numerical Analysis · Mathematics 2022-01-03 Peter Jan van Leeuwen , Dan Crisan , Oana Lang , Roland Potthast

In this paper, we develop a simulation-based framework for regularized logistic regression, exploiting two novel results for scale mixtures of normals. By carefully choosing a hierarchical model for the likelihood by one type of mixture,…

Methodology · Statistics 2015-03-17 Robert B. Gramacy , Nicholas G. Polson