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Graph neural networks (GNNs) have emerged as a powerful tool for learning software engineering tasks including code completion, bug finding, and program repair. They benefit from leveraging program structure like control flow graphs, but…

Machine Learning · Computer Science 2020-10-27 David Bieber , Charles Sutton , Hugo Larochelle , Daniel Tarlow

Single-cell RNA sequencing (scRNA-seq) technology provides high-throughput gene expression data to study the cellular heterogeneity and dynamics of complex organisms. Graph neural networks (GNNs) have been widely used for automatic cell…

Machine Learning · Computer Science 2023-12-19 Rui Yang , Wenrui Dai , Chenglin Li , Junni Zou , Dapeng Wu , Hongkai Xiong

Predicting genetic perturbations enables the identification of potentially crucial genes prior to wet-lab experiments, significantly improving overall experimental efficiency. Since genes are the foundation of cellular life, building gene…

Quantitative Methods · Quantitative Biology 2025-05-09 Changxi Chi , Jun Xia , Jingbo Zhou , Jiabei Cheng , Chang Yu , Stan Z. Li

There are many mathematical models of biochemical cell signaling pathways that contain a large number of elements (species and reactions). This is sometimes a big issue for identifying critical model elements and describing the model…

Molecular Networks · Quantitative Biology 2021-09-15 Hemn Mohammed Rasool , Sarbaz H. A. Khoshnaw

In Model-Based Systems Engineering (MBSE), the Systems Modeling Language (SysML) specification includes a metamodel that defines the language concepts and a user model that defines how the language concepts are represented. In SysML, an…

Software Engineering · Computer Science 2021-11-10 William S. Chao

Objective: The paper focuses on development of robust and accurate processing solutions for continuous and cuff-less blood pressure (BP) monitoring. In this regard, a robust deep learning-based framework is proposed for computation of low…

Machine Learning · Computer Science 2022-01-03 Soheil Zabihi , Elahe Rahimian , Fatemeh Marefat , Amir Asif , Pedram Mohseni , Arash Mohammadi

Biological systems typically involve large numbers of components with complex, highly parallel interactions and intrinsic stochasticity. To model this complexity, numerous programming languages based on process calculi have been developed,…

Programming Languages · Computer Science 2010-11-03 Andrew Phillips , Matthew Lakin , Loïc Paulevé

Invariance-based and generative methods have shown a conspicuous performance for 3D self-supervised representation learning (SSRL). However, the former relies on hand-crafted data augmentations that introduce bias not universally applicable…

Computer Vision and Pattern Recognition · Computer Science 2024-09-25 Naiwen Hu , Haozhe Cheng , Yifan Xie , Shiqi Li , Jihua Zhu

Boundary Representation (B-Rep) is the widely adopted standard in Computer-Aided Design (CAD) and manufacturing. However, generative modeling of B-Reps remains a formidable challenge due to their inherent heterogeneity as geometric cell…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Junran Lu , Yuanqi Li , Hengji Li , Jie Guo , Yanwen Guo

Graph neural networks (GNNs) have become the state of the art for various graph-related tasks and are particularly prominent in heterogeneous graphs (HetGs). However, several issues plague this paradigm: first, the difficulty in fully…

Machine Learning · Computer Science 2025-02-25 Xuqi Mao , Zhenying He , X. Sean Wang

Scientific diagrams convey explicit structural information, yet modern text-to-image models often produce visually plausible but structurally incorrect results. Existing benchmarks either rely on image-centric or subjective metrics…

Computer Vision and Pattern Recognition · Computer Science 2026-02-11 Tong Zhang , Honglin Lin , Zhou Liu , Chong Chen , Wentao Zhang

Modern single-cell flow and mass cytometry technologies measure the expression of several proteins of the individual cells within a blood or tissue sample. Each profiled biological sample is thus represented by a set of hundreds of…

Machine Learning · Computer Science 2022-06-29 Siyuan Shan , Vishal Baskaran , Haidong Yi , Jolene Ranek , Natalie Stanley , Junier Oliva

We present a novel system that automatically extracts and generates informative and descriptive sentences from the biomedical corpus and facilitates the efficient search for relational knowledge. Unlike previous search engines or…

Computation and Language · Computer Science 2023-10-19 Kerui Zhu , Jie Huang , Kevin Chen-Chuan Chang

Graph Neural Networks (GNNs) have shown promise in learning dynamic functional connectivity for distinguishing phenotypes from human brain networks. However, obtaining extensive labeled clinical data for training is often…

Machine Learning · Computer Science 2025-05-06 Jungwon Choi , Hyungi Lee , Byung-Hoon Kim , Juho Lee

The pathway is a biological term that refers to a series of interactions between molecules in a cell that causes a certain product or a change in the cell. Pathway analysis is a powerful method for gene expression analysis. Through pathway…

Data Structures and Algorithms · Computer Science 2022-01-11 Lingran Xiao , Yanfei Wang , Shiying Li , Lingxi Chen , Shuaicheng Li

Blind Image Quality Assessment (BIQA) is a fundamental task in computer vision, which however remains unresolved due to the complex distortion conditions and diversified image contents. To confront this challenge, we in this paper propose a…

Computer Vision and Pattern Recognition · Computer Science 2023-04-12 Guanyi Qin , Runze Hu , Yutao Liu , Xiawu Zheng , Haotian Liu , Xiu Li , Yan Zhang

In biochemical systems some of the chemical species are present with only small numbers of molecules. In this situation discrete and stochastic simulation approaches are more relevant than continuous and deterministic ones. The fundamental…

Computational Engineering, Finance, and Science · Computer Science 2013-03-18 Tae-Hyuk Ahn , Adrian Sandu , Xiaoying Han

Business Process Model and Notation (BPMN) provides a standard for the design of business processes. It focuses on bridging the gap between the analysis and the technical perspectives, and aims to deliver process automation. The aim of this…

Databases · Computer Science 2015-09-01 Anastasios Gounaris

Quantum computers are expected to perform the full-configuration interaction calculations with less computational resources compared to classical ones, thanks to the use of the quantum phase estimation (QPE) algorithms. However, only a…

Quantum Physics · Physics 2024-12-05 Yusuke Ino , Misaki Yonekawa , Hideto Yuzawa , Yuichiro Minato , Kenji Sugisaki

Graph neural networks (GNNs) are increasingly used to model biological systems, yet the reliability of post-hoc explanation methods for recovering meaningful molecular mechanisms remains unclear. Here, we systematically evaluate four widely…

Molecular Networks · Quantitative Biology 2026-05-22 Kyle Higgins , Ivan Laponogov , Dennis Veselkov , Kirill Veselkov