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Boolean networks, widely used to model gene regulation, exhibit a phase transition between regimes in which small perturbations either die out or grow exponentially. We show and numerically verify that this phase transition in the dynamics…

Statistical Mechanics · Physics 2013-05-30 Shane Squires , Edward Ott , Michelle Girvan

Boolean automata networks (aka Boolean networks) are space-time discrete dynamical systems, studied as a model of computation and as a representative model of natural phenomena. A collection of simple entities (the automata) update their…

Discrete Mathematics · Computer Science 2024-02-12 Kévin Perrot , Sylvain Sené , Léah Tapin

We study experimentally the synchronization patterns in time-delayed directed Boolean networks of excitable systems. We observe a transition in the network dynamics when the refractory time of the individual systems is adjusted. When the…

Adaptation and Self-Organizing Systems · Physics 2013-03-07 David P. Rosin , Damien Rontani , Daniel J. Gauthier , Eckehard Schöll

In this article, we design the distributed pinning controllers to globally stabilize a Boolean network (BN), specially a sparsely connected large-scale one, towards a preassigned subset of state space through the node-to-node message…

Systems and Control · Electrical Eng. & Systems 2022-03-16 Shiyong Zhu , Jianquan Lu , Liangjie Sun , Jinde Cao

Boolean networks may be viewed as idealizations of biological genetic networks, where each node is represented by an on-off switch which is a function of the binary output from some other nodes. We evolve connectivity in a single Boolean…

Biological Physics · Physics 2016-09-08 Stefan Bornholdt , Kim Sneppen

A Boolean control network (BCN) is a discrete-time dynamical system whose variables take values from a binary set $\{0,1\}$. At each time step, each variable of the BCN updates its value simultaneously according to a Boolean function which…

Systems and Control · Computer Science 2019-07-23 Qunxi Zhu , Zuguang Gao , Yang Liu , Weihua Gui

As a discrete approach to genetic regulatory networks, Boolean models provide an essential qualitative description of the structure of interactions among genes and proteins. Boolean models generally assume only two possible states…

Molecular Networks · Quantitative Biology 2007-05-23 Madalena Chaves , Eduardo D. Sontag , Reka Albert

This paper presents the foundation for a decomposition theory for Boolean networks, a type of discrete dynamical system that has found a wide range of applications in the life sciences, engineering, and physics. Given a Boolean network…

Dynamical Systems · Mathematics 2022-06-10 Claus Kadelka , Reinhard Laubenbacher , David Murrugarra , Alan Veliz-Cuba , Matthew Wheeler

Boolean networks are discrete dynamical systems for modeling regulation and signaling in living cells. We investigate a particular class of Boolean functions with inhibiting inputs exerting a veto (forced zero) on the output. We give…

Molecular Networks · Quantitative Biology 2014-09-05 Haleh Ebadi , Konstantin Klemm

Boolean networks have been successfully used in modelling gene regulatory networks. In this paper we propose a reduction method that reduces the complexity of a Boolean network but keeps dynamical properties and topological features and…

Quantitative Methods · Quantitative Biology 2009-07-06 Alan Veliz-Cuba

The regulation of the cell state is a complex process involving several components. These complex dynamics can be modeled using Boolean networks, allowing us to explain the existence of different cell states and the transition between them.…

Molecular Networks · Quantitative Biology 2010-01-28 Elke K. Markert , Nils Baas , Arnold J. Levine , Alexei Vazquez

We present a renormalization-grouplike method performed in the state space for detecting the dynamical behaviors of large scale-free Boolean networks, especially for the chaotic regime as well as the edge of chaos. Numerical simulations…

Disordered Systems and Neural Networks · Physics 2007-05-23 Wen-Xu Wang , Gang Yan , Jie Ren , Bing-Hong Wang

Different Boolean networks may reveal similar dynamics although their definition differs, then preventing their distinction from the observations. This raises the question about the sufficiency of a particular Boolean network for properly…

Discrete Mathematics · Computer Science 2014-11-25 Franck Delaplace

Regulatory dynamics in biology is often described by continuous rate equations for continuously varying chemical concentrations. Binary discretization of state space and time leads to Boolean dynamics. In the latter, the dynamics has been…

Biological Physics · Physics 2013-05-29 Fakhteh Ghanbarnejad , Konstantin Klemm

Boolean networks have been widely used in many areas of science and engineering to represent various dynamical behaviour. In systems biology, they became useful tools to study the dynamical characteristics of large-scale biomolecular…

Dynamical Systems · Mathematics 2024-01-01 Jongrae Kim , Woojeong Lee , Kwang-Hyun Cho

We investigate the effect of noise on Random Boolean Networks. Noise is implemented as a probability $p$ that a node does not obey its deterministic update rule. We define two order parameters, the long-time average of the Hamming distance…

Biological Physics · Physics 2009-11-13 Tiago P. Peixoto , Barbara Drossel

In this paper we consider complex dynamical networks modeled by means of state space systems running in discrete time. We assume that the dependency structure of the variables within the (nonlinear) network equations is known and use…

Optimization and Control · Mathematics 2017-03-27 Jacob van der Woude

Dynamical systems theory and complexity science provide powerful tools for analysing artificial agents and robots. Furthermore, they have been recently proposed also as a source of design principles and guidelines. Boolean networks are a…

Artificial Intelligence · Computer Science 2015-03-18 Andrea Roli , Mattia Manfroni , Carlo Pinciroli , Mauro Birattari

We obtain the phase diagram of random Boolean networks with nested canalizing functions. Using the annealed approximation, we obtain the evolution of the number $b_t$ of nodes with value one, and the network sensitivity $\lambda$, and we…

Biological Physics · Physics 2010-12-17 Tiago P. Peixoto

The dynamics of Boolean networks (BN) with quenched disorder and thermal noise is studied via the generating functional method. A general formulation, suitable for BN with any distribution of Boolean functions, is developed. It provides…

Disordered Systems and Neural Networks · Physics 2015-05-27 Alexander Mozeika , David Saad