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T cell receptor signaling must operate reliably under tight time constraints. While assuming quite different mechanisms, two prominent models of T cell receptor activation, kinetic segregation and kinetic proofreading, both introduce a…

Quantitative Methods · Quantitative Biology 2024-12-10 Thorsten Prüstel , Martin Meier-Schellersheim

Combined action of noise and deterministic force in dynamical systems can induce resonant effects. Here, we demonstrate a minimal, deterministic-force-free, setup allowing for occurrence of resonant, noise induced effects. We show that in…

Statistical Mechanics · Physics 2021-07-20 Karol Capała , Bartłomiej Dybiec

The ability to learn and respond to recurrent events depends on the capacity to remember transient biological signals received in the past. Moreover, it may be desirable to remember or ignore these transient signals conditioned upon other…

Molecular Networks · Quantitative Biology 2010-09-17 Georg Fritz , Nicolas E. Buchler , Terence Hwa , Ulrich Gerland

Understanding the mechanisms governing population extinctions is of key importance to many problems in ecology and evolution. Stochastic factors are known to play a central role in extinction, but the interactions between a population's…

Populations and Evolution · Quantitative Biology 2017-11-22 Christopher Spalding , Charles R. Doering , Glenn R. Flierl

Bacteria live in environments that are continuously fluctuating and changing. Exploiting any predictability of such fluctuations can lead to an increased fitness. On longer timescales bacteria can "learn" the structure of these fluctuations…

Cell Behavior · Quantitative Biology 2021-01-05 Stefan Landmann , Caroline M. Holmes , Mikhail Tikhonov

We investigate the influence of a stochastically fluctuating step-barrier potential on bimolecular reaction rates by exact analytical theory and stochastic simulations. We demonstrate that the system exhibits a new resonant reaction…

Chemical Physics · Physics 2016-03-23 Jakob J. Kolb , Stefano Angioletti-Uberti , Joachim Dzubiella

The study of synchronization in biological systems is essential for the understanding of the rhythmic phenomena of living organisms at both molecular and cellular levels. In this paper, by using simple dynamical systems theory, we present a…

Molecular Networks · Quantitative Biology 2007-05-23 Chunguang Li , Luonan Chen , Kazuyuki Aihara

We investigate a method of selectively targeting cancer cells by means of ultrasound harmonic excitation at their resonance frequency, which we refer to as oncotripsy. The geometric model of the cells takes into account the cytoplasm,…

Biological Physics · Physics 2020-07-21 Stefanie Heyden , Michael Ortiz

Stochastic switching between the two bistable states of a strongly driven mechanical resonator enables detection of weak signals based on probability distributions, in a manner that mimics biological systems. However, conventional silicon…

Mesoscale and Nanoscale Physics · Physics 2019-03-27 Robin J. Dolleman , Pierpaolo Belardinelli , Samer Houri , Herre S. J. van der Zant , Farbod Alijani , Peter G. Steeneken

Our understanding of cell division control in bacteria still relies largely on interpreting correlations between phenomenological variables, with limited connection to the underlying molecular mechanisms. Here, we analytically solve a…

We investigate a stochastic version of a simple enzymatic reaction which follows the generic Michaelis-Menten kinetics. At sufficiently high concentrations of reacting species, the molecular fluctuations can be approximated as a realization…

Populations and Evolution · Quantitative Biology 2009-11-13 A. Fiasconaro , A. Ochab-Marcinek , B. Spagnolo , E. Gudowska-Nowak

We present the first experimental realization of a ratchet cellular automaton (RCA) which has been recently suggested as an alternative approach for performing logical operations with interacting (quasi) particles. Our study was performed…

Soft Condensed Matter · Physics 2009-11-11 Dusan Babic , Clemens Bechinger

Antibiotic resistance, which is a serious healthcare issue, emerges due to uncontrolled and repeated antibiotic use that causes bacteria to mutate and develop resistance to antibiotics. The Antibiotics Time Machine Problem aims to come up…

Optimization and Control · Mathematics 2025-01-22 Deniz Tuncer , Burak Kocuk

The goal of this article is to contribute towards the conceptual and quantitative understanding of the evolutionary benefits for (microbial) populations to maintain a seed bank (consisting of dormant individuals) when facing fluctuating…

Probability · Mathematics 2024-07-02 Jochen Blath , Felix Hermann , Martin Slowik

Self-propelled microorganisms, such as unicellular algae or bacteria, swim along their director relative to the fluid velocity. Under a steady shear flow the director rotates in close orbit, a periodic structure that is preserved under an…

Soft Condensed Matter · Physics 2015-06-11 Francisca Guzman-Lastra , Rodrigo Soto

The social organization of microorganisms has long been a fascinating and challenging subject in both biology and sociology. In these organisms, the role of the individual is far less dominant than that of the community, which functions as…

Biological Physics · Physics 2025-03-05 Eleonora Alfinito , Matteo Beccaria

Living cells maintain size homeostasis by actively compensating for size fluctuations. Here, we present two stochastic maps that unify phenomenological models by integrating fluctuating single-cell growth rates and size-dependent noise…

Populations and Evolution · Quantitative Biology 2026-01-09 Arthur Genthon , Philipp Thomas

Phage therapy is an alternative treatment method for bacterial infections. It has shown particular promise in reducing bacterial load while preventing antibiotic resistance. Here, we develop a mathematical model of a bacterial infection…

Populations and Evolution · Quantitative Biology 2025-12-23 Rohan Shirur , Bryce Morsky

The combination of Deep Learning techniques and Raman spectroscopy shows great potential offering precise and prompt identification of pathogenic bacteria in clinical settings. However, the traditional closed-set classification approaches…

Quantitative Methods · Quantitative Biology 2023-10-24 Yaroslav Balytskyi , Nataliia Kalashnyk , Inna Hubenko , Alina Balytska , Kelly McNear

This paper presents an efficient speech enhancement (SE) approach that reuses a processing block repeatedly instead of conventional stacking. Rather than increasing the number of blocks for learning deep latent representations, repeating a…

Audio and Speech Processing · Electrical Eng. & Systems 2026-04-01 Jangyeon Kim , Ui-Hyeop Shin , Jaehyun Ko , Hyung-Min Park