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The increasing availability of population-level allele frequency data across one or more related populations necessitates the development of methods that can efficiently estimate population genetics parameters, such as the strength of…

Computation · Statistics 2017-11-09 Jeffrey J. Gory , Radu Herbei , Laura S. Kubatko

We introduce a modified spatial $\Lambda$-Fleming-Viot process to model the ancestry of individuals in a population occupying a continuous spatial habitat divided into two areas by a sharp discontinuity of the dispersal rate and effective…

Probability · Mathematics 2023-06-14 Raphael Forien , Harald Ringbauer , Graham Coop

A wide range of studies in population genetics have employed the sample frequency spectrum (SFS), a summary statistic which describes the distribution of mutant alleles at a polymorphic site in a sample of DNA sequences. In particular,…

Probability · Mathematics 2016-03-03 John A. Kamm , Jonathan Terhorst , Yun S. Song

Many aspects of the historical relationships between populations in a species are reflected in genetic data. Inferring these relationships from genetic data, however, remains a challenging task. In this paper, we present a statistical model…

Populations and Evolution · Quantitative Biology 2012-11-20 Joseph K. Pickrell , Jonathan K. Pritchard

The rapid development of sequencing technologies represents new opportunities for population genetics research. It is expected that genomic data will increase our ability to reconstruct the history of populations. While this increase in…

Populations and Evolution · Quantitative Biology 2014-12-04 Olivier Mazet , Willy Rodríguez , Lounès Chikhi

Genetic data are often used to infer demographic history and changes or detect genes under selection. Inferential methods are commonly based on models making various strong assumptions: demography and population structures are supposed…

Populations and Evolution · Quantitative Biology 2020-07-28 Clotilde Lepers , Sylvain Billiard , Matthieu Porte , Sylvie Méléard , Viet Chi Tran

The investigation of allele frequency trajectories in populations evolving under controlled environmental pressures has become a popular approach to study evolutionary processes on the molecular level. Statistical models based on…

Machine Learning · Computer Science 2025-07-29 Julia Siekiera , Christian Schlötterer , Stefan Kramer

An explosion of high-throughput DNA sequencing in the past decade has led to a surge of interest in population-scale inference with whole-genome data. Recent work in population genetics has centered on designing inference methods for…

Machine Learning · Computer Science 2018-11-07 Jeffrey Chan , Valerio Perrone , Jeffrey P. Spence , Paul A. Jenkins , Sara Mathieson , Yun S. Song

We investigate a Poisson sampling design in the presence of unknown selection probabilities when applied to a population of unknown size for multiple sampling occasions. The fixed-population model is adopted and extended upon for inference.…

Methodology · Statistics 2020-01-30 Kyle Vincent , Saman Muthukumarana

The distribution of genetic polymorphisms in a population contains information about the mutation rate and the strength of natural selection at a locus. Here, we show that the Poisson Random Field (PRF) method of population-genetic…

Populations and Evolution · Quantitative Biology 2007-07-18 Michael M Desai , Joshua B. Plotkin

With novel developments in sequencing technologies, time-sampled data are becoming more available and accessible. Naturally, there have been efforts in parallel to infer population genetic parameters from these datasets. Here, we compare…

Populations and Evolution · Quantitative Biology 2014-10-01 Matthieu Foll , Hyunjin Shim , Jeffrey D. Jensen

Having a precise knowledge of the dispersal ability of a population in a heterogeneous environment is of critical importance in agroecology and conservation biology as it can provide management tools to limit the effects of pests or to…

Populations and Evolution · Quantitative Biology 2015-03-19 L. Roques , E. Walker , P. Franck , S. Soubeyrand , E. K. Klein

We describe a new and computationally efficient Bayesian methodology for inferring species trees and demographics from unlinked binary markers. Likelihood calculations are carried out using diffusion models of allele frequency dynamics…

Populations and Evolution · Quantitative Biology 2019-09-18 Marnus Stoltz , Boris Bauemer , Remco Bouckaert , Colin Fox , Gordon Hiscott , David Bryant

Inference with population genetic data usually treats the population pedigree as a nuisance parameter, the unobserved product of a past history of random mating. However, the history of genetic relationships in a given population is a…

Populations and Evolution · Quantitative Biology 2019-04-02 Peter L. Ralph

In population genetics, extant samples are usually used for inference of past population genetic forces. With the Kingman coalescent and the backward diffusion equation, inference of the marginal likelihood proceeds from an extant sample…

Populations and Evolution · Quantitative Biology 2020-04-03 Claus Vogl , Sandra Peer

Social media provide access to behavioural data at an unprecedented scale and granularity. However, using these data to understand phenomena in a broader population is difficult due to their non-representativeness and the bias of…

Computers and Society · Computer Science 2019-05-16 Zijian Wang , Scott A. Hale , David Adelani , Przemyslaw A. Grabowicz , Timo Hartmann , Fabian Flöck , David Jurgens

Comparing allele frequencies among populations that differ in environment has long been a tool for detecting loci involved in local adaptation. However, such analyses are complicated by an imperfect knowledge of population allele…

Populations and Evolution · Quantitative Biology 2012-09-17 Torsten Günther , Graham Coop

A central statistical problem in population genetics is to infer evolutionary and biological parameters such as the strength of natural selection and allele age from DNA samples extracted from a contemporary population. That all samples…

Populations and Evolution · Quantitative Biology 2025-02-19 Jaromir Sant , Paul A. Jenkins , Jere Koskela , Dario Spano

A number of discrete time, finite population size models in genetics describing the dynamics of allele frequencies are known to converge (subject to suitable scaling) to a diffusion process in the infinite population limit, termed the…

Probability · Mathematics 2021-09-14 Jaromir Sant , Paul A. Jenkins , Jere Koskela , Dario Spano

The increased availability of time series genetic variation data from experimental evolution studies and ancient DNA samples has created new opportunities to identify genomic regions under selective pressure and to estimate their associated…

Populations and Evolution · Quantitative Biology 2015-01-27 Matthias Steinrücken , Anand Bhaskar , Yun S. Song
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