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In many fields, researchers are interested in large and complex biological processes. Two important examples are gene expression and DNA methylation in genetics. One key problem is to identify aberrant patterns of these processes and…

Applications · Statistics 2012-10-03 Matthias Kormaksson , James G. Booth , Maria E. Figueroa , Ari Melnick

It has been hypothesized that some form of "modular" structure in artificial neural networks should be useful for learning, compositionality, and generalization. However, defining and quantifying modularity remains an open problem. We cast…

Machine Learning · Computer Science 2022-06-23 Richard D. Lange , David S. Rolnick , Konrad P. Kording

AI-enabled precision medicine promises a transformational improvement in healthcare outcomes by enabling data-driven personalized diagnosis, prognosis, and treatment. However, the well-known "curse of dimensionality" and the clustered…

Machine Learning · Computer Science 2023-05-19 Amanda M. Buch , Conor Liston , Logan Grosenick

Datasets with a mixture of numerical and categorical attributes are routinely encountered in many application domains. In this work we examine an approach to clustering such datasets using homogeneity analysis. Homogeneity analysis…

Machine Learning · Statistics 2017-10-31 Rajiv Sambasivan , Sourish Das

Despite its popularity, it is widely recognized that the investigation of some theoretical aspects of clustering has been relatively sparse. One of the main reasons for this lack of theoretical results is surely the fact that, whereas for…

Statistics Theory · Mathematics 2015-12-11 José E. Chacón

An agglomerative clustering of random variables is proposed, where clusters of random variables sharing the maximum amount of multivariate mutual information are merged successively to form larger clusters. Compared to the previous…

Information Theory · Computer Science 2017-02-27 Chung Chan , Ali Al-Bashabsheh , Qiaoqiao Zhou

Clustering is widely used in unsupervised learning to find homogeneous groups of observations within a dataset. However, clustering mixed-type data remains a challenge, as few existing approaches are suited for this task. This study…

Machine Learning · Statistics 2025-11-26 Badih Ghattas , Alvaro Sanchez San-Benito

A general framework for dealing with both linear regression and clustering problems is described. It includes Gaussian clusterwise linear regression analysis with random covariates and cluster analysis via Gaussian mixture models with…

Methodology · Statistics 2015-10-13 Giuliano Galimberti , Annamaria Manisi , Gabriele Soffritti

Clustering scientific publications can reveal underlying research structures within bibliographic databases. Graph-based clustering methods, such as spectral, Louvain, and Leiden algorithms, are frequently utilized due to their capacity to…

Digital Libraries · Computer Science 2025-05-27 Vu Thi Huong , Thorsten Koch

There is a growing need for unbiased clustering methods, ideally automated. We have developed a topology-based analysis tool called Two-Tier Mapper (TTMap) to detect subgroups in global gene expression datasets and identify their…

Genomics · Quantitative Biology 2018-01-08 Rachel Jeitziner , Mathieu Carrière , Jacques Rougemont , Steve Oudot , Kathryn Hess , Cathrin Brisken

The number of accidents and health diseases which are increasing at an alarming rate are resulting in a huge increase in the demand for blood. There is a necessity for the organized analysis of the blood donor database or blood banks…

Databases · Computer Science 2013-09-11 Bondu Venkateswarlu , Prof G. S. V. Prasad Raju

In this paper, we compare and analyze clustering methods with missing data in health behavior research. In particular, we propose and analyze the use of compressive sensing's matrix completion along with spectral clustering to cluster…

Numerical Analysis · Mathematics 2014-04-24 Ran Zhao , Deanna Needell , Christopher Johansen , Jerry L. Grenard

Distributed data mining techniques and mainly distributed clustering are widely used in the last decade because they deal with very large and heterogeneous datasets which cannot be gathered centrally. Current distributed clustering…

Databases · Computer Science 2018-02-02 Malika Bendechache , M-Tahar Kechadi

An approach to improve neural network interpretability is via clusterability, i.e., splitting a model into disjoint clusters that can be studied independently. We define a measure for clusterability and show that pre-trained models form…

Machine Learning · Computer Science 2025-07-28 Satvik Golechha , Maheep Chaudhary , Joan Velja , Alessandro Abate , Nandi Schoots

An original graph clustering approach to efficient localization of error covariances is proposed within an ensemble-variational data assimilation framework. Here the localization term is very generic and refers to the idea of breaking up a…

Statistics Theory · Mathematics 2020-02-03 Sibo Cheng , Jean-Philippe Argaud , Bertrand Iooss , Angélique Ponçot , Didier Lucor

Hierarchical clustering is a powerful tool for exploratory data analysis, organizing data into a tree of clusterings from which a partition can be chosen. This paper generalizes these ideas by proving that, for any reasonable hierarchy, one…

Machine Learning · Computer Science 2025-11-13 Andrew Draganov , Pascal Weber , Rasmus Skibdahl Melanchton Jørgensen , Anna Beer , Claudia Plant , Ira Assent

In cluster analysis, it can be useful to interpret the partition built from the data in the light of external categorical variables which were not directly involved to cluster the data. An approach is proposed in the model-based clustering…

Cluster analysis of very high dimensional data can benefit from the properties of such high dimensionality. Informally expressed, in this work, our focus is on the analogous situation when the dimensionality is moderate to small, relative…

Machine Learning · Statistics 2017-04-07 Fionn Murtagh

Cluster analysis is one of the essential tasks in data mining and knowledge discovery. Each type of data poses unique challenges in achieving relatively efficient partitioning of the data into homogeneous groups. While the algorithms for…

Machine Learning · Computer Science 2018-12-11 Ruben A. Gevorgyan , Yenok B. Hakobyan

We construct an extension of diffusion geometry to multiple modalities through joint approximate diagonalization of Laplacian matrices. This naturally extends classical data analysis tools based on spectral geometry, such as diffusion maps…

Computer Vision and Pattern Recognition · Computer Science 2012-09-13 Davide Eynard , Klaus Glashoff , Michael M. Bronstein , Alexander M. Bronstein